公开(公告)号：EP1053245A1

公开(公告)日：2000-11-22

申请号：EP99905667.4

申请日：1999-02-04

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  SHI, Yanggu ,  ROSEN, Craig, A. ,  LAFLEUR, David, W. ,  MOORE, Paul, A. ,  KYAW, Hla ,  WEI, Ying-Fei

IPC分类号： C07H21/00 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N15/79

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1044212A1

公开(公告)日：2000-10-18

申请号：EP99901303.0

申请日：1999-01-06

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  MOORE, Paul, A. ,  WEI, Ying-Fei

IPC分类号： C07H21/04 ,  A61K38/00 ,  A61K39/395 ,  C07K1/00 ,  C07K16/00 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  A01N61/00 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to novel human FK506 binding proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human FK506 binding proteins. The inventioon further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human proteins.

公开(公告)号：EP0990031A2

公开(公告)日：2000-04-05

申请号：EP98904528.1

申请日：1998-01-13

申请人： Human Genome Sciences, Inc.

发明人： WEI, Ying-Fei ,  NI, Jian ,  EBNER, Reinhard ,  YU, Guo-Liang ,  RUBEN, Steven, M. ,  GENTZ, Reiner, L. ,  FENG, Ping

IPC分类号： C12N15/12 ,  C12N15/70 ,  C12N15/85 ,  C12N15/86 ,  C12N1/21 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  A61K38/17

CPC分类号： C07K14/70578 ,  A61K48/00

摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as 'TNFR-5' or 'TR5', and now referred to hereinafter as 'TRAIL receptor without intracellular domain' or 'TRID'. TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

公开(公告)号：EP0990031B1

公开(公告)日：2006-03-29

申请号：EP98904528.1

申请日：1998-01-13

申请人： HUMAN GENOME SCIENCES, INC.

发明人： WEI, Ying-Fei ,  NI, Jian ,  EBNER, Reinhard ,  YU, Guo-Liang ,  RUBEN, Steven, M. ,  GENTZ, Reiner, L. ,  FENG, Ping

IPC分类号： C12N15/12 ,  C12N15/70 ,  C12N15/85 ,  C12N15/86 ,  C12N1/21 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  A61K38/17

CPC分类号： C07K14/70578 ,  A61K48/00

摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as "TNFR-5" or "TR5", and now referred to hereinafter as "TRAIL receptor without intracellular domain" or "TRID". TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

公开(公告)号：EP1244686A1

公开(公告)日：2002-10-02

申请号：EP00983862.4

申请日：2000-12-01

申请人： Human Genome Sciences, Inc.

发明人： WEI, Ying-Fei

IPC分类号： C07H21/04 ,  C12N1/21 ,  C12N15/00 ,  C12P21/00 ,  C07K14/495 ,  C07K16/22 ,  A61K38/18 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/495 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to a novel human protein called Transforming Growth Factor Alpha III, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

公开(公告)号：EP0826041B1

公开(公告)日：2010-12-08

申请号：EP95921317.4

申请日：1995-05-19

申请人： HUMAN GENOME SCIENCES, INC.

发明人： WEI, Ying-Fei ,  MEISSNER, Paul, S. ,  NI, Jian

IPC分类号： C12N15/12 ,  C12N15/18 ,  C12N15/19 ,  C07K14/495

CPC分类号： C07K14/495 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

公开(公告)号：EP1088071A1

公开(公告)日：2001-04-04

申请号：EP99930252.4

申请日：1999-06-15

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  NI, Jian ,  ROSEN, Craig, A. ,  WEI, Ying-Fei ,  YOUNG, Paul, E. ,  FLORENCE, Kimberly, A. ,  SOPPET, Daniel, R. ,  BREWER, Laurie A. ,  ENDRESS, Gregory, A. ,  CARTER, Kenneth, C. ,  MUCENSKI, Michael ,  EBNER, Reinhard ,  LAFLEUR, David, W. ,  OLSEN, Henrik, S. ,  SHI, Yanggu ,  MOORE, Paul, A. ,  KOMATSOULIS, George

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N1/21 ,  C12N5/00 ,  C07K7/00 ,  C07K14/435

CPC分类号： G01N33/6893 ,  A61K38/00 ,  C07K14/47 ,  G01N2500/20

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1042674A1

公开(公告)日：2000-10-11

申请号：EP98956146.9

申请日：1998-10-23

申请人： HUMAN GENOME SCIENCES, INC.

发明人： FENG, Ping ,  ROSEN, Craig A. ,  RUBEN, Steven M. ,  NI, Jian ,  WEI, Ying-Fei ,  SOPPET, Daniel R. ,  MOORE, Paul A. ,  KAYW, Hla ,  LAFLEUR, David W. ,  OLSEN, Henrik S. ,  BREWER, Laurie A. ,  SHI, Yanggu ,  EBNER, Reinhard ,  YOUNG, Paul ,  GREENE, John M. ,  FLORENCE, Kimberly A. ,  FLORENCE, Charles ,  DUAN, D. Roxanne ,  JANAT, Fouad ,  ENDRESS, Gregory A. ,  CARTER, Kenneth C.

IPC分类号： G01N33/68 ,  G01N33/53 ,  C07K16/00 ,  C12N15/11 ,  C12N15/12 ,  C12N15/00 ,  C12N15/63 ,  A61K38/17 ,  A61K38/16 ,  C12P21/02

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP0873360A1

公开(公告)日：1998-10-28

申请号：EP96902605.0

申请日：1996-01-04

申请人： HUMAN GENOME SCIENCES, INC.

发明人： WEI, Ying-Fei

IPC分类号： C07K14 ,  A61K38

CPC分类号： C07K14/495 ,  A61K38/00

摘要： The present invention discloses transforming growth factor alpha HIII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

公开(公告)号：EP0749496A1

公开(公告)日：1996-12-27

申请号：EP95909338.0

申请日：1995-01-25

申请人： HUMAN GENOME SCIENCES, INC.

发明人： HASELTINE, William A. ,  RUBEN, Steven M. ,  WEI, Ying-Fei ,  ADAMS, Mark D. ,  FLEISCHMANN, Robert D. ,  FRASER, Claire M. ,  FULDNER, Rebecca A. ,  KIRKNESS, Ewen F. ,  ROSEN, Craig A.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K48 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1 ,  C12R1

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The invention provides methods to diagnose alterations in the hMLH1, hMLH2 and hMLH3 genes.