公开(公告)号：EP1039801A1

公开(公告)日：2000-10-04

申请号：EP98926237.3

申请日：1998-06-04

申请人： HUMAN GENOME SCIENCES, INC.

发明人： YOUNG, Paul ,  GREENE, John ,  FERRIE, Ann, M. ,  RUBEN, Steven ,  ROSEN, Craig ,  HU, Jing-Shan ,  OLSEN, Henrik ,  EBNER, Reinhard ,  BREWER, Laurie, A. ,  MOORE, Paul, A. ,  SHI, Yanggu e ,  FLORENCE, Charles ,  FLORENCE, Kimberly ,  LAFLEUR, David ,  NI, Jian ,  FAN, Ping ,  WEI, Ying-Fei ,  FISCHER, Carrie ,  SOPPET, Daniel ,  LI, Yi ,  ZENG, Zizhen ,  KYAW, Hla ,  YU, Guo-Liang ,  FENG, Ping ,  DILLON, Patrick ,  ENDRESS, Gregory ,  CARTER, Kenneth

IPC分类号： A01N37/18

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4718 ,  G01N33/68

公开(公告)号：EP0763045A1

公开(公告)日：1997-03-19

申请号：EP95922424.0

申请日：1994-05-10

申请人： HUMAN GENOME SCIENCES, INC.

发明人： KIRKNESS, Ewen ,  ADAMS, Mark, D. ,  OLSEN, Henrik ,  ROSEN, Craig

IPC分类号： C12N15 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P7 ,  A61P25 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Disclosed is a human maturation factor polypeptide and DNA(RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases related to the underexpression of such human haemopoietic maturation factor polypeptide.

公开(公告)号：EP1924596A2

公开(公告)日：2008-05-28

申请号：EP06813242.2

申请日：2006-07-31

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig ,  BELL, Adam ,  MOORE, Paul ,  SHI, Yanggu ,  LAFLEUR, David ,  LAIRD, Michael ,  HASELTINE, William ,  WOODS, Douglas ,  BOCK, Jason ,  SUBRAMANIAN, Mani

IPC分类号： C07K14/00

CPC分类号： C07K14/765 ,  A61K47/643 ,  C07K2319/00

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

摘要翻译： 本发明包括清蛋白融合蛋白。 编码本发明的清蛋白融合蛋白的核酸分子也包括在本发明中，含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的清蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 此外，本发明涵盖包含清蛋白融合蛋白的药物组合物以及使用本发明的清蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。