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1.发明公开VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH 有权VEGI，EIN INHIBITOR DER ANGIOGENESE UND DES TUMORWACHSTUMS
公开(公告)号：EP1042343A4
公开(公告)日：2001-08-16
申请号：EP98958456
申请日：1998-11-02
发明人： LI LU-YUAN , ZHAI YIFAN , YU GUO-LIANG , NI JIAN , LIPPMAN MARC E , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P27/02 , A61P27/06 , A61P35/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C12Q1/68 , C07H21/00 , A01N43/04 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
摘要翻译： 本发明涉及能够抑制动物模型中细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。
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公开(公告)号：EP2211888A4
公开(公告)日：2010-11-17
申请号：EP08843705
申请日：2008-10-30
发明人： ROSEN CRAIG A , BELL ADAM , MOORE PAUL A , SHI YANGGU , LAFLEUR DAVID , BOCK JASON B , LAIRD MICHAEL W , HASELTINE WILLIAM A , WOODS DOUGLAS B , SUBRAMANIAN MANI
CPC分类号： C07K14/58 , C07K14/765 , C07K2319/01
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公开(公告)号：EP1499353A4
公开(公告)日：2006-04-05
申请号：EP03728362
申请日：2003-04-10
发明人： ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： A61K39/395 , A61K31/7088 , A61K47/48 , A61K51/10 , A61P35/00 , A61P37/00 , C07K16/28 , C12N1/21 , C12N5/24 , C12N15/13 , C12N15/70 , C12Q1/68 , G01N33/577 , G01N33/68
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding antiTL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.
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4.发明公开NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开NEUTROKIN ALPHA AND NEUTROKIN ALPHA SPONGE VARIANT
公开(公告)号：EP1507793A4
公开(公告)日：2006-02-01
申请号：EP02786413
申请日：2002-10-16
发明人： YU GUO-LIANG , EBNER REINHARD , NI JIAN , ROSEN CRAIG A , LAIRD MICHAEL W , ULLRICH STEPHEN
CPC分类号： A61K51/08 , A61K38/00 , C07K14/525
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公开(公告)号：EP1228082A4
公开(公告)日：2005-11-16
申请号：EP00947553
申请日：2000-07-20
发明人： ROSEN CRAIG A , RUBEN STEVEN M , EBNER REINHARD , DUAN ROXANNE D , NI JIAN , SOPPET DANIEL R , MOORE PAUL A , SHI YANG-GU , LAFLEUR DAVID W , OLSEN HENRIK S , BIRSE CHARLES E , KOMATSOULIS GEORGES A
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K5/04 , C07K16/00
CPC分类号： C07H21/04 , C07K14/47 , C07K16/18 , C07K2317/622 , C07K2319/30
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公开(公告)号：EP1370651A4
公开(公告)日：2005-04-06
申请号：EP02714961
申请日：2002-02-21
发明人： ROSEN CRAIG A , KOMATSOULIS GEORGE , BAKER KEVIN P , FISCELLA MICHELE , MOORE PAUL A , WEI PING , DUAN D ROXANNE , SHI YANGGU , GUPTA RAM
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68 , C12N15/00 , A61K38/00 , C07K14/705 , C07K16/18 , C12N5/10 , G01N33/50
CPC分类号： C07K14/47
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公开(公告)号：EP1062236A4
公开(公告)日：2005-03-23
申请号：EP99911423
申请日：1999-03-11
发明人： RUBEN STEVEN M , FERRIE ANN M , ROSEN CRAIG A , FLORENCE CHARLES , YOUNG PAUL E , YU GUO-LIANG , NI JIAN
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P1/04 , A61P7/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C07K14/435 , C12N5/00 , C12N15/12 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
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公开(公告)号：EP1313761A4
公开(公告)日：2005-01-26
申请号：EP01904899
申请日：2001-01-17
发明人： ROSEN CRAIG A , KOMATSOULIS GEORGE A , BAKER KEVIN P , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H , FISCELLA MICHELE , NI JIAN
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00 , A61K48/00
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公开(公告)号：EP1325020A4
公开(公告)日：2004-12-15
申请号：EP01910321
申请日：2001-01-09
发明人： KOMATSOULIS GEORGE A , BAKER KEVIN P , ROSEN CRAIG A , BIRSE CHARLES E , SOPPET DANIEL R , OLSEN HENRIK S , NI JIAN , FISCELLA MICHELE , MOORE PAUL A , WEI PING , EBNER REINHARD , DUAN D ROXANNE , SHI YANGGU , CHOI GIL H
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公开(公告)号：EP0909320A4
公开(公告)日：2004-12-01
申请号：EP96922504
申请日：1996-06-17
发明人： WEI YING-FEI , KREIDER BRENT L , ROSEN CRAIG A
IPC分类号： G01N33/53 , A61K38/00 , A61K38/19 , A61P37/00 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/523 , A61K38/00 , C12N2799/026
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine beta -15 protein. Chemokine beta -15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
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