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公开(公告)号：EP2457592A1
公开(公告)日：2012-05-30
申请号：EP10802225.2
申请日：2010-07-15
发明人： TERAHARA Takaaki , TOKUMOTO Seiji , TAMURA Akira , YAMADA Yumiko
CPC分类号： A61K9/0021 , A61B5/150022 , A61B5/150282 , A61B5/150427 , A61B5/150511 , A61B5/150969 , A61B5/150984 , A61K47/34 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
摘要： Relations between crystallinity and performance of a biodegradable resin, between weight-average molecular weight and strength thereof, and between weight-average molecular weight and performance thereof were clarified. As a result thereof, when a microneedle array was provided with microneedles containing noncrystalline polylactic acid which had a weight-average molecular weight of 40,000 to 100,000, it was possible to obtain a microneedle array which could maintain its functional performance.
摘要翻译： 澄清了可生物降解树脂的结晶度和性能之间的关系，其重均分子量和强度之间以及重均分子量和性能之间的关系。 作为其结果，当微针阵列设置有包含重均分子量为40,000至100,000的非结晶性聚乳酸的微针时，可以获得可保持其功能性能的微针阵列。
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公开(公告)号：EP2865378A1
公开(公告)日：2015-04-29
申请号：EP13807634.4
申请日：2013-06-17
CPC分类号： A61K31/196 , A61K9/0014 , A61K9/7038 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K47/12 , A61K47/20
摘要： A patch comprising a support layer and an adhesive layer,
wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium : mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium : mass of dimethyl sulfoxide) is 1:0.75 to 1:3.摘要翻译： 1。一种贴剂，其包含支撑层和粘合剂层，其中所述粘合剂层包含双氯芬酸钠，二甲基亚砜和柠檬酸; 双氯芬酸钠与柠檬酸的质量比（双氯芬酸钠的质量：柠檬酸的质量）为1:0.15至1:0.45; 双氯芬酸钠与二甲基亚砜的质量比（双氯芬酸钠的质量：二甲基亚砜的质量）为1：0.75〜1：3。
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公开(公告)号：EP2865378B1
公开(公告)日：2017-11-01
申请号：EP13807634.4
申请日：2013-06-17
IPC分类号： A61K9/70 , A61K47/12 , A61K47/20 , A61K31/196 , A61P29/00
CPC分类号： A61K31/196 , A61K9/0014 , A61K9/7038 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K47/12 , A61K47/20
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公开(公告)号：EP2441437A1
公开(公告)日：2012-04-18
申请号：EP10786220.3
申请日：2010-06-10
发明人： TERAHARA Takaaki , TOKUMOTO Seiji
CPC分类号： A61K9/0021 , A61K47/34 , A61M37/0015 , A61M2037/0023 , Y02A50/471
摘要： A coating agent has been applied to microneedles having a biodegradable resin, and a relation between its strength and performance has been clarified. As a result thereof, it has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength or more, that is, a predetermined weight average molecular weight, allows the microneedles to have excellent performance. Further, it has been found that in regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate the performance. In view of this, when a microneedle device 1 is arranged so that at least a part of a microneedle array 2 provided with microneedles 3 made from polylactic acid having a weight average molecular weight of 40,000 or more is coated with a carrier containing physiologically active ingredients, it is possible to attain excellent migration characteristics of the physiologically active ingredients to a living body.
摘要翻译： 已经将涂布剂应用于具有生物可降解树脂的微针，并且其强度和性能之间的关系已经明确。 其结果发现，通过在规定强度以上，即规定的重均分子量的生物降解性树脂的微针上涂布涂布剂，微针的性能优异。 此外，已经发现，就涂层剂而言，其预定类型和量对于表现性能也是有用的。 鉴于此，当微针装置1被布置为使得具有重均分子量为40,000或更高的聚乳酸制成的微针3的微针阵列2的至少一部分被包含生理活性成分的载体 ，可以实现生理活性成分对生物体的优异迁移特性。
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公开(公告)号：EP2441437B1
公开(公告)日：2018-08-08
申请号：EP10786220.3
申请日：2010-06-10
发明人： TERAHARA Takaaki , TOKUMOTO Seiji
CPC分类号： A61K9/0021 , A61K47/34 , A61M37/0015 , A61M2037/0023 , Y02A50/471
摘要： A coating agent has been applied to microneedles having a biodegradable resin, and a relation between its strength and performance has been clarified. As a result thereof, it has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength or more, that is, a predetermined weight average molecular weight, allows the microneedles to have excellent performance. Further, it has been found that in regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate the performance. In view of this, when a microneedle device 1 is arranged so that at least a part of a microneedle array 2 provided with microneedles 3 made from polylactic acid having a weight average molecular weight of 40,000 or more is coated with a carrier containing physiologically active ingredients, it is possible to attain excellent migration characteristics of the physiologically active ingredients to a living body.
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6.发明公开MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVIVE 审中-公开微针装置和方法改进流感疫苗的效率利用微针装置
公开(公告)号：EP2327419A1
公开(公告)日：2011-06-01
申请号：EP09773249.9
申请日：2009-05-22
申请人： Hisamitsu Pharmaceutical Co., Inc. , Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： NOZAKI Chikateru , KAMINAKA Kazuyoshi , MATSUDA Junichi , TERAHARA Takaaki , KUWAHARA Tetsuji , TOKUMOTO Seiji
IPC分类号： A61K39/145 , A61K9/00 , A61K9/70 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/34 , A61K47/36 , A61L31/00 , A61M37/00 , A61P31/16
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译： 本发明提供了用于使用能够增强流感疫苗的免疫原性的微针装置增强的免疫原性的方法。 。根据该方法用于增强使用本微针装置的免疫原性，具有微针的微针装置由聚乳酸的，在具有A型株（H1N1）抗原组成的流感疫苗涂覆有A型株（H3N2），和类型 B株作为活性成分被带入与皮肤直接接触，以便经皮施用上述的流感疫苗。 经皮给药后，月桂醇被应用到微针系统已经直接接触皮肤的部位。
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