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    ARRAY WITH FINE PROTRUSIONS
    3.
    发明公开
    ARRAY WITH FINE PROTRUSIONS 审中-公开
    具有精细突起的阵列

    公开(公告)号：EP2578265A1

    公开(公告)日：2013-04-10

    申请号：EP11786694.7

    申请日：2011-05-25

    申请人： Hisamitsu Pharmaceutical Co., Inc. ,  Toppan Printing Co., Ltd.

    发明人： TOKUMOTO Seiji ,  ISHITSUKA Shuji ,  KODAMA Yoshihiro ,  TAKEMURA Nobumi

    IPC分类号： A61M37/00

    CPC分类号： A61K9/00 ,  A61M37/0015 ,  A61M2037/0038

    摘要： An array 1 with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0

    摘要翻译： 具有微凸体的阵列1包括基体2和逐渐变细的微凸体3，每个微凸体3设置在基体2上并从底部向尖端逐渐变细。 将从微小突起3的任意一侧的前端到下端的距离设为a，将通过将表示距离a的第一线段投影到基底2上而准备的第二线段的长度设为b，则关系为1.0 <（a / b）≤7.5成立。

    MICRONEEDLE DEVICE
    4.
    发明公开
    MICRONEEDLE DEVICE 审中-公开

    公开(公告)号：EP3586906A1

    公开(公告)日：2020-01-01

    申请号：EP18758313.3

    申请日：2018-02-20

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： MACHIDA Kazuya ,  NISHIMURA Shinpei ,  TOKUMOTO Seiji

    IPC分类号： A61M37/00

    摘要： A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 µm, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm 2 , and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.

    APPLICATOR
    5.
    发明公开
    APPLICATOR 审中-公开

    公开(公告)号：EP3560545A1

    公开(公告)日：2019-10-30

    申请号：EP17885207.5

    申请日：2017-12-15

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： TAJIMA Takuya ,  YAMAMOTO Naoki ,  TOKUMOTO Seiji

    IPC分类号： A61M37/00 ,  A61M35/00

    摘要： An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.

    METHOD FOR PRODUCING MICRONEEDLE DEVICE
    7.
    发明公开
    METHOD FOR PRODUCING MICRONEEDLE DEVICE 审中-公开

    公开(公告)号：EP3586905A1

    公开(公告)日：2020-01-01

    申请号：EP18756585.8

    申请日：2018-02-20

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： KOBAYASHI Toru ,  MATSUDO Toshiyuki ,  NISHIMURA Shinpei ,  TOKUMOTO Seiji ,  KUWAHARA Tetsuji

    IPC分类号： A61M37/00

    摘要： A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

    MICRO-NEEDLE DEVICE AND PREPARATION METHOD
    9.
    发明公开
    MICRO-NEEDLE DEVICE AND PREPARATION METHOD 审中-公开
    MIKRONADELVORRICHTUNG UND HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP2540337A1

    公开(公告)日：2013-01-02

    申请号：EP11747468.4

    申请日：2011-02-24

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： MATSUDO Toshiyuki ,  NISHIMURA Shinpei ,  TOKUMOTO Seiji ,  MORIMOTO Kumi

    IPC分类号： A61M37/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y02A50/389

    摘要： The present invention provides a micro-needle device that includes a substrate, a micro-needle provided on the substrate, and a physiologically active composition deposited on the micro-needle and/or the substrate. In the micro-needle device, the physiologically active composition contains: at least one polyhydric alcohol selected from glycerin, ethylene glycol, propylene glycol and 1,3-butylene glycol; and a physiologically active substance, and contains substantially no water.

    摘要翻译： 本发明提供了一种微针装置，其包括基底，设置在基底上的微针和沉积在微针和/或基底上的生理活性组合物。 在微针装置中，生理活性组合物包含：至少一种选自甘油，乙二醇，丙二醇和1,3-丁二醇的多元醇; 和生理活性物质，并且基本上不含水。

    MICRONEEDLE DEVICE
    10.
    发明授权
    MICRONEEDLE DEVICE 有权

    公开(公告)号：EP2441437B1

    公开(公告)日：2018-08-08

    申请号：EP10786220.3

    申请日：2010-06-10

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： TERAHARA Takaaki ,  TOKUMOTO Seiji

    IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61M37/00

    CPC分类号： A61K9/0021 ,  A61K47/34 ,  A61M37/0015 ,  A61M2037/0023 ,  Y02A50/471

    摘要： A coating agent has been applied to microneedles having a biodegradable resin, and a relation between its strength and performance has been clarified. As a result thereof, it has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength or more, that is, a predetermined weight average molecular weight, allows the microneedles to have excellent performance. Further, it has been found that in regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate the performance. In view of this, when a microneedle device 1 is arranged so that at least a part of a microneedle array 2 provided with microneedles 3 made from polylactic acid having a weight average molecular weight of 40,000 or more is coated with a carrier containing physiologically active ingredients, it is possible to attain excellent migration characteristics of the physiologically active ingredients to a living body.