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公开(公告)号：EP1042343B1
公开(公告)日：2008-01-23
申请号：EP98958456.0
申请日：1998-11-02
发明人： LI, Lu-Yuan , ZHAI, Yifan , YU, Guo-Liang , NI, Jian , LIPPMAN, Marc, E. , ROSEN, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
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公开(公告)号：EP1042343A1
公开(公告)日：2000-10-11
申请号：EP98958456.0
申请日：1998-11-02
发明人： LI, Lu-Yuan , ZHAI, Yifan , YU, Guo-Liang , NI, Jian , LIPPMAN, Marc, E. , ROSEN, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
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公开(公告)号：EP1054968A1
公开(公告)日：2000-11-29
申请号：EP99910970.5
申请日：1999-02-19
发明人： EBNER, Reinhard , YU, Guo-Liang , RUBEN, Steven, M. , ZHANG, Jun , ULLRICH, Stephen , ZHAI, Yifan
IPC分类号： C12N15/12 , C07K14/705 , A61K38/16 , C07K16/28 , G01N33/50 , C12Q1/68 , A61K48/00 , G01N33/68
CPC分类号： C07K14/70575 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026 , C12N2799/027 , Y02A50/412
摘要： The present invention relates to a member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.
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公开(公告)号：EP1161261A1
公开(公告)日：2001-12-12
申请号：EP00914913.9
申请日：2000-03-10
申请人： Human Genome Sciences, Inc. , Ebner, Reinhard , Yu, Guo-Liang , Ruben, Steven M. , Zhai, Yifan , Ullrich, Stephen
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , A61P37/00 , A61P35/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K45/06 , C07K14/4747 , C07K14/70575 , C07K16/2866 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system deseases, graft versus host desease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.
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