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公开(公告)号：EP1042343B1
公开(公告)日：2008-01-23
申请号：EP98958456.0
申请日：1998-11-02
发明人： LI, Lu-Yuan , ZHAI, Yifan , YU, Guo-Liang , NI, Jian , LIPPMAN, Marc, E. , ROSEN, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
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公开(公告)号：EP1042343A1
公开(公告)日：2000-10-11
申请号：EP98958456.0
申请日：1998-11-02
发明人： LI, Lu-Yuan , ZHAI, Yifan , YU, Guo-Liang , NI, Jian , LIPPMAN, Marc, E. , ROSEN, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
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公开(公告)号：EP0961831B1
公开(公告)日：2008-10-29
申请号：EP96928886.9
申请日：1996-08-16
发明人： YU, Guo-Liang , NI, Jian , ROSEN, Craig, A.
CPC分类号： C07K14/5255 , A61K38/00 , C07K14/52
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公开(公告)号：EP0970213B1
公开(公告)日：2007-01-24
申请号：EP98912966.3
申请日：1998-03-17
IPC分类号： C12N15/12 , C07K14/715 , C07K16/28 , A61K38/17 , A61K39/395 , C12N15/62
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
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公开(公告)号：EP0897390B1
公开(公告)日：2003-11-12
申请号：EP96910483.5
申请日：1996-03-14
发明人： NI, Jian , YU, Guo-Liang , GENTZ, Reiner, L. , DILLON, Patrick J.
IPC分类号： C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C12N5/00 , C12N15/09 , C12N15/63 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00 , A61K48/00 , Y02A50/411 , Y02A50/58
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
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公开(公告)号：EP1159286A1
公开(公告)日：2001-12-05
申请号：EP00916071.4
申请日：2000-03-03
发明人： GENTZ, Reiner, L. , NI, Jian , EBNER, Reinhard , YU, Guo-Liang , RUBEN, Steven, M. , FENG, Ping
CPC分类号： C07K14/7151 , A61K38/00
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α and -6β proteins. TNFR-6α and -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α and -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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公开(公告)号：EP1039801A1
公开(公告)日：2000-10-04
申请号：EP98926237.3
申请日：1998-06-04
发明人： YOUNG, Paul , GREENE, John , FERRIE, Ann, M. , RUBEN, Steven , ROSEN, Craig , HU, Jing-Shan , OLSEN, Henrik , EBNER, Reinhard , BREWER, Laurie, A. , MOORE, Paul, A. , SHI, Yanggu e , FLORENCE, Charles , FLORENCE, Kimberly , LAFLEUR, David , NI, Jian , FAN, Ping , WEI, Ying-Fei , FISCHER, Carrie , SOPPET, Daniel , LI, Yi , ZENG, Zizhen , KYAW, Hla , YU, Guo-Liang , FENG, Ping , DILLON, Patrick , ENDRESS, Gregory , CARTER, Kenneth
IPC分类号： A01N37/18
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4718 , G01N33/68
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公开(公告)号：EP1015477A1
公开(公告)日：2000-07-05
申请号：EP98926105.2
申请日：1998-05-28
发明人： RUBEN, Steven, M. , ROSEN, Craig, A. , CARTER, Kenneth, C. , DILLON, Patrick, J. , ENDRESS, Gregory, A. , YU, Guo-Liang , NI, Jian , FENG, Ping
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP0988371A1
公开(公告)日：2000-03-29
申请号：EP98926471.8
申请日：1998-06-10
发明人： NI, Jian , YU, Guo-Liang , FAN, Ping , GENTZ, Reiner, L.
IPC分类号： C12N1/21
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/7151 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
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公开(公告)号：EP0961831A1
公开(公告)日：1999-12-08
申请号：EP96928886.0
申请日：1996-08-16
发明人： YU, Guo-Liang , NI, Jian , ROSEN, Craig, A.
IPC分类号： C12N15 , A61K39 , A61P35 , A61P37 , C07H21 , C07K1 , C07K14 , C07K16 , C12N1 , C12P21 , C12Q1 , A61K38 , C12R1
CPC分类号： C07K14/5255 , A61K38/00 , C07K14/52
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译： 本发明涉及肿瘤坏死因子（TNF）家族细胞因子的新成员。 具体而言，提供了编码内因子α蛋白的分离的核酸分子。 还提供了内因子α多肽，如载体，宿主细胞和用于生产它们的重组方法。 还提供了关于TNF家族相关疾病的诊断和治疗方法。
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