公开(公告)号：EP1242400A1

公开(公告)日：2002-09-25

申请号：EP00987999.0

申请日：2000-11-28

申请人： ICOS CORPORATION

发明人： MARTINS, Timothy, J. ,  FOWLER, Kerry, W. ,  ODINGO, Joshua ,  KESICKI, Edward, A. ,  OLIVER, Amy ,  BURGESS, Laurence, E. ,  GAUDINO, John, J. ,  JONES, Zachary, S. ,  NEWHOUSE, Bradley, J. ,  SCHLACHTER, Stephen

IPC分类号： C07D295/20 ,  C07D295/18 ,  C07D417/06 ,  C07D401/12 ,  C07D295/14 ,  C07D405/06 ,  C07D401/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/06 ,  C07D407/12 ,  C07D413/12 ,  C07D407/06 ,  C07D409/12 ,  A61K31/40

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

公开(公告)号：EP1242400B1

公开(公告)日：2006-05-03

申请号：EP00987999.0

申请日：2000-11-28

申请人： ICOS Corporation

发明人： MARTINS, Timothy, J. ,  FOWLER, Kerry, W. ,  ODINGO, Joshua ,  KESICKI, Edward, A. ,  OLIVER, Amy ,  BURGESS, Laurence, E. ,  GAUDINO, John, J. ,  JONES, Zachary, S. ,  NEWHOUSE, Bradley, J. ,  SCHLACHTER, Stephen

IPC分类号： C07D295/20 ,  C07D295/18 ,  C07D417/06 ,  C07D401/12 ,  C07D295/14 ,  C07D405/06 ,  C07D401/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/06 ,  C07D407/12 ,  C07D413/12 ,  C07D407/06 ,  C07D409/12 ,  A61K31/40

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

公开(公告)号：EP1244619A1

公开(公告)日：2002-10-02

申请号：EP00984450.7

申请日：2000-12-15

申请人： ICOS CORPORATION

发明人： MARTINS, Timothy, J. ,  FOWLER, Kerry, W. ,  ODINGO, Joshua ,  BURGESS, Laurence, E. ,  SCHLACHTER, Stephen, T.

IPC分类号： C07D207/09 ,  A61K31/40 ,  A61P29/00

CPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/454 ,  A61K45/06 ,  C07D207/09 ,  Y02A50/411 ,  A61K2300/00

摘要： Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory disease and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

公开(公告)号：EP1351946A2

公开(公告)日：2003-10-15

申请号：EP01968164.2

申请日：2001-08-28

申请人： ICOS CORPORATION

发明人： HALBROOK, James ,  KESICKI, Edward ,  BURGESS, Laurence, E. ,  SCHLACHTER, Stephen, T. ,  EARY, Charles, T. ,  SCHIRO, Justin, G. ,  HUANG, Hongmei ,  EVANS, Michael ,  HAN, Yongxin

IPC分类号： C07D295/12 ,  A61K31/435 ,  A61P35/00 ,  C07D295/22 ,  C07D211/26 ,  C07D295/18 ,  C07D211/42 ,  C07D295/14 ,  C07D295/10 ,  C07D239/42 ,  C07D295/20

CPC分类号： C07D213/40 ,  A61K45/06 ,  C07C309/66 ,  C07D209/36 ,  C07D211/42 ,  C07D211/46 ,  C07D213/50 ,  C07D213/74 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D235/26 ,  C07D239/48 ,  C07D249/08 ,  C07D277/24 ,  C07D277/54 ,  C07D279/12 ,  C07D295/096 ,  C07D295/112 ,  C07D295/13 ,  C07D295/135 ,  C07D295/155 ,  C07D295/185 ,  C07D295/215 ,  C07D295/30 ,  C07D307/83 ,  C07D309/10 ,  C07D311/30 ,  C07D333/22 ,  C07D405/04 ,  C07D417/12 ,  C07F9/6533 ,  C07F9/65785

摘要： Compounds of Formula (I) that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.