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1.发明公开Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor 失效通过粒细胞 - 巨噬细胞集落刺激因子激活巨噬细胞的杀肿瘤活性。
公开(公告)号：EP0211684A2
公开(公告)日：1987-02-25
申请号：EP86306304.6
申请日：1986-08-15
申请人： IMMUNEX CORPORATION
发明人： Anderson, Dirk M. , Cantrell, Michael A. , Cerretti, Douglas P. , Conlon, Paul J., III , Cosman, David J. , Grabstein, Kenneth H. , Larsen, Alf D. , Price, Virginia L.
CPC分类号： C07K14/535 , A61K38/00 , Y10S530/828
摘要： Macrophages and precursor monocytes are activated to exhibit tumoricidal activity by stimulation solely with granulocyte-macrophage colony stimulating factor. A patient suffering from tumors can be treated by direct administration of therapeutically effective quantities of activated granulocyte-macrophage colony stimulating factor. Homogeneous granulocyte-macrophage colony stimulating factor for use in activating macrophages and monocyte precursors is prepared by recombinant DNA techniques. The gene coding for granulocyte-macrophage colony stimulating factor is isolated and then recombinant protein product expressed in an appropriate expression system. The granulocyte-macrophage colony stimulating factor recovered from the expression system is purified to homogeneity by reverse phase high-performance liquid chromatography.
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2.发明公开Immunoregulator from the family designated 'leukocyte immunoglobulin-like receptors' (LIR) 审中-公开从家庭标记为“Leukozytenimmunoglobulin样受体”的免疫调节剂（LIR）
公开(公告)号：EP1772515A1
公开(公告)日：2007-04-11
申请号：EP06019248.1
申请日：2000-05-12
申请人： IMMUNEX CORPORATION
IPC分类号： C12N15/12 , C12N15/62 , C07K14/705 , C07K19/00 , C07K16/28
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/70503 , C07K2319/00
摘要： A family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defmed nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
摘要翻译： 免疫球蛋白超家族的免疫受体分子家族，（LIR）多肽进行说明。 公开了编码LIR家族成员及其推导的氨基酸序列的序列，通过DNA编码的多肽没有杂交的核苷酸序列所定义，其制备LIR家族的多肽处理，和特异性抗体针对LIR多肽。 LIR家族成员可用于治疗与免疫功能抑制相关的自身免疫性疾病和疾病状态。
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3.发明公开Receptor activator of NF-KAPPA B, receptor is member of TNF receptor superfamily 失效配体NF-κB的受体活化因子，TNF配体是超家族的成员
公开(公告)号：EP2371962A3
公开(公告)日：2011-12-21
申请号：EP10182860.6
申请日：1997-12-22
申请人： Immunex Corporation
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
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公开(公告)号：EP2009025B1
公开(公告)日：2011-07-27
申请号：EP08015570.8
申请日：1999-05-13
申请人： Immunex Corporation
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K14/70578 , C07K2319/00 , C07K2319/30 , C07K2319/73 , Y10S530/866
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5.发明公开Ligand for receptor activator of NF-kappa B, ligand is member of TNF superfamily 失效NF-kappa B的配体活化剂配体，配体结合TNF超家族
公开(公告)号：EP2314695A2
公开(公告)日：2011-04-27
申请号：EP10182863.0
申请日：1997-12-22
申请人： Immunex Corporation
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also useful in screening for inhibitors thereof.
摘要翻译： 公开了分离的配体，编码这些配体的DNA，以及由此制备的药物组合物。 分离的配体可用于调节免疫应答。 配体也可用于筛选其抑制剂。
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6.发明公开
公开(公告)号：EP2009025A1
公开(公告)日：2008-12-31
申请号：EP08015570.8
申请日：1999-05-13
申请人： IMMUNEX CORPORATION
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K14/70578 , C07K2319/00 , C07K2319/30 , C07K2319/73 , Y10S530/866
摘要： Isolated soluble RANK receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate osteoclastogenesis, and hence treat disease in which there is excess bone loss.
摘要翻译： 公开了分离的可溶性RANK受体，编码这种受体的DNA，以及由其制备的药物组合物。 分离的受体可用于调节破骨细胞形成，因此治疗其中存在多余骨丢失的疾病。
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7.发明授权Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor 失效通过粒细胞巨噬细胞集落刺激因子激活巨噬细胞活性
公开(公告)号：EP0211684B1
公开(公告)日：1992-07-08
申请号：EP86306304.6
申请日：1986-08-15
申请人： IMMUNEX CORPORATION
发明人： Anderson, Dirk M. , Cantrell, Michael A. , Cerretti, Douglas P. , Conlon, Paul J., III , Cosman, David J. , Grabstein, Kenneth H. , Larsen, Alf D. , Price, Virginia L.
CPC分类号： C07K14/535 , A61K38/00 , Y10S530/828
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8.发明公开Ligand for receptor activator of NF-kappa B, ligand is member of TNF superfamily 失效配体NF-κB的配体的受体激活剂是TNF超家族的成员
公开(公告)号：EP2314695A3
公开(公告)日：2011-12-21
申请号：EP10182863.0
申请日：1997-12-22
申请人： Immunex Corporation
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also useful in screening for inhibitors thereof.
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9.发明公开Receptor activator of NF-KAPPA B, receptor is member of TNF receptor superfamily 失效Rezeptor Aktivator von NF-KAPPA B，Rezeptor ist Mitglied der Rezeptor Superfamilie
公开(公告)号：EP2371962A2
公开(公告)日：2011-10-05
申请号：EP10182860.6
申请日：1997-12-22
申请人： Immunex Corporation
CPC分类号： C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要： Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
摘要翻译： 公开了分离的受体，编码这种受体的DNA，以及由此制备的药物组合物。 分离的受体可用于调节免疫应答。 受体也可用于筛选其抑制剂。
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公开(公告)号：EP0215576B1
公开(公告)日：1992-04-01
申请号：EP86306303.8
申请日：1986-08-15
申请人： IMMUNEX CORPORATION
发明人： Anderson, Dirk M. , Baker, Paul E. , Cantrell, Michael A. , Cerretti, Douglas P. , Cosman, David J. , Gimpel, Steven D. , Grabstein, Kenneth H. , Larsen, Alf D. , McKereghan, Kate N.
CPC分类号： C07K14/55 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/73
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