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1.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING IMFLAMMATORY BOWEL DISEASES 审中-公开方法和药物组合物预防或治疗炎性肠道疾病
公开(公告)号：EP3167892A1
公开(公告)日：2017-05-17
申请号：EP15306788.9
申请日：2015-11-10
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Pierre et Marie Curie (Paris 6) , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
发明人： SOKOL, Harry , LAVIE-RICHARD, Mathias , MICHEL, Marie-Laure , LAMAS, Bruno Michel , LANGELLA, Philippe
CPC分类号： A61K35/741 , C12N1/20 , C12R1/01 , G01N33/6875 , G01N2800/065 , G01N2800/52
摘要： The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
摘要翻译： 本发明涉及的方法和用于预防或治疗炎症性肠疾病的药物组合物。
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公开(公告)号：EP3337492A1
公开(公告)日：2018-06-27
申请号：EP16763211.6
申请日：2016-08-22
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Pierre et Marie Curie (Paris 6) , Institut National de la Recherche Agronomique (INRA) , Centre National de la Recherche Scientifique (CNRS) , Assistance Publique-Hôpitaux de Paris (APHP)
发明人： SOKOL, Harry , LAVIE-RICHARD, Mathias , MICHEL, Marie-Laure , LAMAS, Bruno Michel , LANGELLA, Philippe
IPC分类号： A61K35/741 , C12R1/01 , A61P1/04 , C12N1/20 , A61P29/02 , G01N33/50 , A61K35/747
CPC分类号： A61K35/747 , A61P1/00 , C12R1/225 , G01N33/5008 , G01N2333/70567 , G01N2500/00 , G01N2800/065 , G01N2800/52 , Y02A50/473
摘要： The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.
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公开(公告)号：EP3758723A1
公开(公告)日：2021-01-06
申请号：EP19706289.6
申请日：2019-02-28
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Paris , Sorbonne Université , Assistance Publique-Hôpitaux de Paris (APHP) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
IPC分类号： A61K35/741 , A61K9/48 , A23L33/135 , A61P3/06 , A61P9/12 , A61P3/10 , A61K31/405 , A61K45/06
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4.发明公开FAECALIBACTERIUM PRAUSNITZII STRAINS FOR TREATING AND PREVENTING GASTROINTESTINAL PAIN 审中-公开FAECALIBACTERIUM PRAUSNITZII菌株用于治疗和预防胃肠道疼痛
公开(公告)号：EP3218524A1
公开(公告)日：2017-09-20
申请号：EP15797929.5
申请日：2015-11-13
申请人： Institut National de la Recherche Agronomique (INRA) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Pierre et Marie Curie (Paris 6) , Assistance Publique-Hôpitaux de Paris (APHP) , Ecole D'ingenieurs De Purpan
发明人： LANGELLA, Philippe , MIQUEL, Sylvie , MARTIN ROSIQUE, Rebeca , BERMUDEZ HUMARAN, Luis , THOMAS, Muriel , SOKOL, Harry , CARVALHO, Frédéric , THEODOROU, Vassilia
IPC分类号： C12R1/01 , A61K35/741
摘要： The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
摘要翻译： 本发明涉及用于治疗和/或预防个体的内脏腹痛的选自属于菌门群I，II和III之一的细菌菌株的普氏假丝酵母菌种的细菌菌株。 本发明还涉及包含所述细菌菌株以及特定菌株的组合物。
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公开(公告)号：EP3218524B1
公开(公告)日：2020-01-08
申请号：EP15797929.5
申请日：2015-11-13
申请人： Institut National de la Recherche Agronomique (INRA) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Pierre et Marie Curie (Paris 6) , Assistance Publique-Hôpitaux de Paris (APHP) , Ecole D'ingenieurs De Purpan
发明人： LANGELLA, Philippe , MIQUEL, Sylvie , MARTIN ROSIQUE, Rebeca , BERMUDEZ HUMARAN, Luis , THOMAS, Muriel , SOKOL, Harry , CARVALHO, Frédéric , THEODOROU, Vassilia
IPC分类号： C12R1/01 , A61K35/741
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6.发明公开
公开(公告)号：EP3875098A1
公开(公告)日：2021-09-08
申请号：EP20305228.7
申请日：2020-03-04
申请人： INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT , Assistance Publique Hôpitaux de Paris , SORBONNE UNIVERSITE , INSERM (Institut National de la Santé et de la Recherche Médicale)
摘要： The present invention relates to the preventive or curative treatment of metabolic syndrome and associated disorders, and inflammatory bowel diseases using Coprococcus bacteria and/or culture supernatants thereof.
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7.发明公开DIAGNOSIS, PROGNOSIS AND TREATMENT OF INFLAMMATORY BOWEL DISEASES 审中-公开DIAGNOSE，PROGNOSE UND BEHANDLUNG VON CHRONISCHENTZÜNDLICHENDARMERKRANKUNGEN
公开(公告)号：EP3019864A1
公开(公告)日：2016-05-18
申请号：EP14738517.3
申请日：2014-07-11
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (C.N.R.S.) , Université d'Angers , Universite de Nantes , CHU Nantes , Université Pierre et Marie Curie (Paris 6) , Assistance Publique Hôpitaux de Paris
发明人： JOTEREAU, Francine , SOKOL, Harry , BOSSARD, Céline , ALTARE, Frederic , SARRABAYROUSE, Guillaume
IPC分类号： G01N33/50
CPC分类号： G01N33/56972 , A61K35/17 , A61K35/74 , A61K39/0208 , A61K2039/5154 , G01N33/5091 , G01N2800/065
摘要： The invention relates to methods comprising a step consisting of determining the proportion and/or the level of T regulatory lymphocytes with a CD4+ CD8ααlow Foxp3neg phenotype specific for Faecalibacterium prausnitzii for (i) diagnosing, (ii) prognosing outcome of, or (iii) predicting the risk of developing, an inflammatory bowel disease in a patient. The invention also concerns the treatment of an inflammatory bowel disease. The invention further relates to the kits that are useful in the above methods for diagnosing/prognosing an inflammatory bowel disease, and in the treatment of an inflammatory bowel disease. In a particular embodiment, the inflammatory bowel disease is the Crohn's disease.
摘要翻译： 本发明涉及包括测定T调节性淋巴细胞比例和/或水平的T调节性淋巴细胞的比例和/或水平与用于（i）诊断，（ii）预测预后或（iii）预测结果的CD4 +CD8αα低Foxp3neg表型特异于福克斯假丝酵母 发生患者的炎症性肠病的风险。 本发明还涉及炎症性肠病的治疗。 本发明还涉及可用于诊断/预后炎症性肠病和用于治疗炎症性肠病的上述方法中的试剂盒。 在一个具体实施方案中，炎症性肠病是克罗恩病。
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公开(公告)号：EP2938353B1
公开(公告)日：2018-08-15
申请号：EP13831825.8
申请日：2013-12-26
发明人： LANGELLA Philippe , PIGNEUR-ARNAUD, Bénédicte , CHATEL, Jean-Marc , TRUGNAN, Germain , QUEVRAIN, Elodie , SEKSIK, Philippe , BERMUDEZ-HUMARAN, Luis G. , CHAIN, Florian , MAUBERT, Marie-Anne , SOKOL, Harry , MICHON, Christophe
IPC分类号： A61K38/16
CPC分类号： A61K38/164 , A61K35/74 , C07K14/195
摘要： The present invention relates to a polypeptide comprising or consisting of the amino acid sequence SEQ ID NO:1, for use in the treatment or prevention of an inflammatory disease. The invention further encompasses a nucleic acid sequence encoding a polypeptide of the invention, a vector comprising a nucleic acid of the invention and a host cell comprising a nucleic acid sequence and/or a vector of the invention, for use in the treatment or prevention of an inflammatory disease. The invention also concerns a pharmaceutical composition comprising a polypeptide, a nucleic acid sequence, a vector or a host cell of the invention and a pharmaceutically acceptable carrier, for the treatment of inflammatory disease.
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9.发明公开
公开(公告)号：EP3407902A1
公开(公告)日：2018-12-05
申请号：EP17702322.3
申请日：2017-01-23
申请人： Institut National de la Recherche Agronomique (INRA) , Sorbonne Universite , Assistance Publique - Hôpitaux de Paris
发明人： LANGELLA, Philippe , MARTIN ROSIQUE, Rebeca , BERMUDEZ HUMARAN, Luis , CHAIN, Florian , SOKOL, Harry
IPC分类号： A61K35/741 , C12R1/01 , A23L33/135 , A61P1/00 , A61P29/00
摘要： The invention relates to a bacterial strain of species
Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
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