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公开(公告)号：EP1144348B1
公开(公告)日：2006-02-08
申请号：EP99943016.8
申请日：1999-09-21
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie
IPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
CPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
摘要： The invention concerns LTA4 hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
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公开(公告)号：EP1165491A1
公开(公告)日：2002-01-02
申请号：EP00917145.5
申请日：2000-04-06
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , PIETTRE, Serge
IPC分类号： C07C229/12 , C07F9/38 , A61P29/00
CPC分类号： C07F9/3808 , C07C45/30 , C07C47/277 , C07C229/08 , C07C251/02 , C07F9/4006
摘要： The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
摘要翻译： 本发明涉及抑制式（I）的LTA4水解酶的化合物。 本发明还涉及它们的治疗，特别是抗炎应用。
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公开(公告)号：EP1165491B1
公开(公告)日：2004-02-11
申请号：EP00917145.5
申请日：2000-04-06
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , PIETTRE, Serge
IPC分类号： C07C229/12 , C07F9/38 , A61P29/00
CPC分类号： C07F9/3808 , C07C45/30 , C07C47/277 , C07C229/08 , C07C251/02 , C07F9/4006
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公开(公告)号：EP1144348A3
公开(公告)日：2002-09-11
申请号：EP99943016.8
申请日：1999-09-21
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie
IPC分类号： C07C1/00
CPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
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5.发明授权PROCEDE DE SYNTHESE ASYMETRIQUE DES DERIVES S-ACYLES DE L'ACIDE 2-MERCAPTOMETHYL 3-PHENYL PROPANOIQUE, APPLICATION A LA SYNTHESE DE DERIVES N-(MERCAPTOACYL) AMINO-ACIDES 失效程序对2-巯基-3-苯基及其用于合成N- mercaptoacyl氨基衍生物的S-酰化衍生物的不对称合成
公开(公告)号：EP0820439B1
公开(公告)日：2000-05-03
申请号：EP97904485.6
申请日：1997-02-04
发明人： DANVY, Denis , MONTEIL, Thierry , DUHAMEL, Pierre , DUHAMEL, Lucette , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles , NOEL-LEFEBRVRE, Nadine , GROS, Claude , PLAQUEVENT, Jean-Christophe
IPC分类号： C07C327/32 , C07B53/00
CPC分类号： C07C29/149 , C07C59/48 , C07C327/32 , C07C33/26
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公开(公告)号：EP1144348A2
公开(公告)日：2001-10-17
申请号：EP99943016.8
申请日：1999-09-21
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie
IPC分类号： C07C1/00
CPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
摘要： The invention concerns LTA4 hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
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7.发明公开PROCEDE DE SYNTHESE ASYMETRIQUE DES DERIVES S-ACYLES DE L'ACIDE 2-MERCAPTOMETHYL 3-PHENYL PROPANOIQUE, APPLICATION A LA SYNTHESE DE DERIVES N-(MERCAPTOACYL) AMINO-ACIDES 失效程序对2-巯基-3-苯基及其用于合成N- mercaptoacyl氨基衍生物的S-酰化衍生物的不对称合成
公开(公告)号：EP0820439A1
公开(公告)日：1998-01-28
申请号：EP97904485.0
申请日：1997-02-04
发明人： DANVY, Denis , MONTEIL, Thierry , DUHAMEL, Pierre , DUHAMEL, Lucette , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles , NOEL-LEFEBRVRE, Nadine , GROS, Claude , PLAQUEVENT, Jean-Christophe
CPC分类号： C07C29/149 , C07C59/48 , C07C327/32 , C07C33/26
摘要： A method for the asymmetrical synthesis of S-acylated derivatives of 2-mercaptomethyl 3-phenyl propanoic acid of formula (I) is disclosed. The method comprises the steps of (a) preparing diol (VI) by reducing a malonic ester (V) in the presence of a hydride; (b) preparing respective monoacetates (VII R) or (VII S); (c) oxidising the monoacetates to give acids (IX S) or (IX R); (d) saponifying compounds (IX S) or (IX R) to form hydroxyacids (X S) or (X R); and (e) thioacylating hydroxyacids (X S) or (X R) with a mercaptoacid R1SH (XI) using a Mitsunobu reaction to give the desired acids (I R) or (I S), respectively. The method is useful for synthesising N-(mercaptoacyl) amino acids of formula (II).
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