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公开(公告)号：EP0828851B1
公开(公告)日：2005-07-20
申请号：EP96916181.9
申请日：1996-05-09
发明人： ROSE, Christiane , VARGAS, Froylan , BOURGEAT, Pierre , SCHWARTZ, Jean-Charles , BISHOP, Paul, Beaumont , BAMBAL, Ramesh, Babarao , GANELLIN, Charon, Robin , LEBLOND, Bertrand , MOORE, Andrew, N., J. , CHAN, Suzanne , LIHUA, Zhao
CPC分类号： C07K5/06052 , A61K38/00 , C07D209/42 , C07K5/06026 , C07K5/06191 , C12Q1/37 , G01N2333/595
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公开(公告)号：EP1165491A1
公开(公告)日：2002-01-02
申请号：EP00917145.5
申请日：2000-04-06
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , PIETTRE, Serge
IPC分类号： C07C229/12 , C07F9/38 , A61P29/00
CPC分类号： C07F9/3808 , C07C45/30 , C07C47/277 , C07C229/08 , C07C251/02 , C07F9/4006
摘要： The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
摘要翻译： 本发明涉及抑制式（I）的LTA4水解酶的化合物。 本发明还涉及它们的治疗，特别是抗炎应用。
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公开(公告)号：EP1042288B1
公开(公告)日：2007-11-07
申请号：EP98966427.1
申请日：1998-12-23
发明人： SCHWARTZ, Jean-Charles , ROSE, Christiane , VARGAS, Froylan, Nathan SmithKline Instit. Neuroch , GANELLIN, Charon, Robin , ZHAO, Lihua , SAMAD, Sanjeeda , CHEN, Yongjun
IPC分类号： C07D209/42 , A61K31/40 , C07D209/60 , C07D491/04
CPC分类号： C07D209/42
摘要： The invention is relative to a compound of formula (I), wherein R?1, R2, R3¿ and n are as defined, together with a process for its preparation. The invention is also relative to the use of a compound (I) as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the treatment of eating disorder, obesity, psychotic syndromes and associated psychiatric disorders. It concerns also the cosmetic use of a compound (I) in particular to aid slimming.
摘要翻译： 本发明涉及其中R 1，R 2，R 3和n如上所定义的式（I）化合物及其制备方法。 本发明还涉及化合物（I）作为CCK灭活肽酶三肽基肽酶（TPP II）的抑制剂的用途。 本发明特别涉及进食障碍，肥胖症，精神病综合征和相关精神障碍的治疗。 它还涉及化合物（I）的化妆品用途，特别是用于帮助减肥。
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4.发明公开
公开(公告)号：EP0597088A1
公开(公告)日：1994-05-18
申请号：EP93914482.0
申请日：1993-01-08
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel, 160, av. du Général-Leclerc , GARBARG, Monique , LECOMTE, Jeanne-Marie , GANELLIN, Charon, Robin , TERTIUK, Wasyl 81 The Commons , SCHUNACK, Walter , LIPP, Ralph , STARK, Holger , PURAND, Katja
CPC分类号： C07D233/64 , C07D233/84 , C07D401/12 , C07D403/12 , C07D417/12
摘要： L'invention concerne des dérivés de l'imidazole répondant à la formule générale (IA) ou (IB). Procédés pour la préparation de ces composés et composition pharmaceutique les incorporant.
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5.发明公开
公开(公告)号：EP0482183A1
公开(公告)日：1992-04-29
申请号：EP91910312.0
申请日：1991-05-10
发明人： GARBARG, Monique , ARRANG, Jean-Michel 160 avenue du Général-Leclerc , SCHUNACK, Walter , LIPP, Ralph , STARK, Holger , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles
CPC分类号： C07D233/64
摘要： Les composés proviennent d'une amine R-NH2 ayant une forte affinité pour le récepteur H3 de l'histamine et à la fonction amine primaire de laquelle est lié un groupe déterminant une liaison lentement hydrolysable en milieu neutre. Les compositions pharmaceutiques comprennent ces composés et un véhicule ou excipient pharmaceutiquement acceptable. Ces composés sont utilisés pour la réalisation d'un médicament inhibiteur de la synthèse et de la libération d'histamine, notamment à effets sédatifs, régulateur du sommeil, anticonvulsivant, antidépresseur, antiallergique, anti-inflammatoire, antisécrétoire ou antiulcéreux.
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公开(公告)号：EP0760811B1
公开(公告)日：2009-11-18
申请号：EP96908172.8
申请日：1996-03-21
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , QUEMENER, Agnès , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , PURAND, Katja , HÜLS, Annette , REIDEMEISTER, Sybille , ATHMANI, Salah , GANELLIN, Charon, Robin , PELLOUX-LEON, Nadia , TERTIUX, Wasyl , KRAUSE, Michael, C., O. , BASSEM, Sadek
IPC分类号： C07D233/64 , C07D409/12 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , A61K31/415
CPC分类号： C07D233/56 , C07D233/64 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , G01N33/567 , G01N33/74 , G01N2333/726
摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.
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公开(公告)号：EP0760811A1
公开(公告)日：1997-03-12
申请号：EP96908172.0
申请日：1996-03-21
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , QUEMENER, Agnès , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , PURAND, Katja , HÜLS, Annette , REIDEMEISTER, Sybille , ATHMANI, Salah , GANELLIN, Charon, Robin , PELLOUX-LEON, Nadia , TERTIUX, Wasyl , KRAUSE, Michael, C., O. , BASSEM, Sadek
IPC分类号： G01N33 , A61K31 , A61P1 , A61P7 , A61P9 , A61P11 , A61P13 , A61P15 , A61P17 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D233 , C07D401 , C07D405 , C07D409 , C07D411 , C07D413
CPC分类号： C07D233/56 , C07D233/64 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , G01N33/567 , G01N33/74 , G01N2333/726
摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.
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公开(公告)号：EP1144348B1
公开(公告)日：2006-02-08
申请号：EP99943016.8
申请日：1999-09-21
发明人： DANVY, Denis , MONTEIL, Thierry , PLAQUEVENT, Jean-Christophe , DUHAMEL, Pierre , DUHAMEL, Lucette , NOEL, Nadine , GROS, Claude , CHAMARD, Olivier , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie
IPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
CPC分类号： C07C323/25 , C07C327/30 , C07D213/64 , C07D317/64
摘要： The invention concerns LTA4 hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
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9.发明授权
公开(公告)号：EP0597088B1
公开(公告)日：2000-12-06
申请号：EP93914482.0
申请日：1993-01-08
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel, 160, av. du Général-Leclerc , GARBARG, Monique , LECOMTE, Jeanne-Marie , GANELLIN, Charon, Robin , FKYERAT, Abdellatif , TERTIUK, Wasyl 81 The Commons , SCHUNACK, Walter , LIPP, Ralph , STARK, Holger , PURAND, Katja
IPC分类号： C07D233/64 , C07D233/84 , C07D403/12 , C07D401/12 , C07D417/12 , A61K31/415
CPC分类号： C07D233/64 , C07D233/84 , C07D401/12 , C07D403/12 , C07D417/12
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10.发明授权COMPOSES AGONISTES DU RECEPTEUR H3 DE L'HISTAMINE A USAGE THERAPEUTIQUE, COMPOSITIONS PHARMACEUTIQUES AGISSANT COMME AGONISTES DUDIT RECEPTEUR ET PROCEDE DE PREPARATION 失效组胺H3受体激动剂对于治疗用途，药物制剂H3受体激动性的工作，他们介绍联合国的方法
公开(公告)号：EP0482183B1
公开(公告)日：1997-07-30
申请号：EP91910312.7
申请日：1991-05-10
发明人： GARBARG, Monique , ARRANG, Jean-Michel 160 avenue du Général-Leclerc , SCHUNACK, Walter , LIPP, Ralph , STARK, Holger , LECOMTE, Jeanne-Marie , SCHWARTZ, Jean-Charles
IPC分类号： C07D233/54 , A61K31/415
CPC分类号： C07D233/64
摘要： The compounds are derived from an R-NH2 amine with a strong affinity for the histamine H3-receptor and to the primary amine function of which is bonded a group forming a bond which can hydrolyze slowly in a neutral medium. The pharmaceutical compositions consist of these compounds and a pharmaceutically acceptable excipient. The compounds are used to produce a drug inhibiting histamine synthesis and release, and having, in particular, sedative, sleep regulating, anti-convulsive, anti-depressive, anti-allergic anti-inflammatory, anti-secretory or anti-ulcerous effects.
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