公开(公告)号：EP1644489A2

公开(公告)日：2006-04-12

申请号：EP04767869.3

申请日：2004-07-02

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BRIAND, Jean-Paul ,  BOULANGER, Pierre ,  BOULANGER, Saw See ,  FRENKEL, Valérie ,  GUILLET, Jean-Gérard ,  BLONDEL, Armelle ,  LENGAGNE, Renée

IPC分类号： C12N5/06

CPC分类号： C07K14/005 ,  A61K39/39 ,  A61K2039/55516 ,  C12N5/0639 ,  C12N2501/998 ,  C12N2710/10322

摘要： The invention relates to a peptide immune booster, comprising: a polypeptide (i) with an amino acid sequence having a length of 30 amino acids contained in the head domain of the fibre protein of the capsid of an adenovirus, said amino acid sequence comprising the sequence of amino acids forming a double ß sheet called EF, contained in said head domain, or a peptide analogue (ii) of said polypeptide (i), the amino acid sequence of which has, by comparison with the sequence of polypeptide (i), at least one substitution or at least one deletion of an amino acid, said analogue peptide conserving the double ß sheet called EF .

公开(公告)号：EP1015618B1

公开(公告)日：2003-07-02

申请号：EP98920613.1

申请日：1998-04-10

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE MONTREAL

发明人： BOUVIER, Michel ,  LOISEL, Thomas ,  MARULLO, Stefano ,  BOULANGER, Pierre ,  STROSBERG, Arthur, Donny

IPC分类号： C12N15/86 ,  C07K14/72 ,  C12N7/02

CPC分类号： C12N15/86 ,  C07K14/723 ,  C12N2710/14143

摘要： The invention concerns the production of membrane receptors in an insect baculovirus/cell system; said receptors are obtained from extracellular baculoviruses produced by the infected cells.

公开(公告)号：EP0900280A2

公开(公告)日：1999-03-10

申请号：EP98905474.0

申请日：1998-01-30

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BOULANGER, Pierre ,  HONG, Saw, See ,  KARAYAN, Lucie

IPC分类号： C12N15 ,  A61K31 ,  A61K48 ,  C07K9 ,  C07K14 ,  C12N5 ,  G01N33 ,  A61K38

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C07K14/70539 ,  C07K14/78 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/40 ,  C12N2810/80 ,  C12N2810/859 ,  C12N2830/00 ,  C12N2830/60

摘要： The invention concerns the use of a polypeptide comprising at least 6 continuous amino acids of the sequence as shown in the sequence identifiers 1 to 5 as cell receptor and/or co-receptor of adenoviruses. It also concerns the use of a cell capable of expressing such a polypeptide and that of a ligand capable of influencing the binding of an adenovirus to a host cell and/or its insertion in said cell. Finally, the invention further concerns a method for selecting or identifying a cell receptor of a virus or part of a viral protein determining the binding of the virus to its cell receptor and the use of a bi-functional ligand for targeting an adenovirus towards a host cell bearing on its surface a surface protein other than the natural cell receptor of said adenovirus.