公开(公告)号：EP1644489A2

公开(公告)日：2006-04-12

申请号：EP04767869.3

申请日：2004-07-02

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BRIAND, Jean-Paul ,  BOULANGER, Pierre ,  BOULANGER, Saw See ,  FRENKEL, Valérie ,  GUILLET, Jean-Gérard ,  BLONDEL, Armelle ,  LENGAGNE, Renée

IPC分类号： C12N5/06

CPC分类号： C07K14/005 ,  A61K39/39 ,  A61K2039/55516 ,  C12N5/0639 ,  C12N2501/998 ,  C12N2710/10322

摘要： The invention relates to a peptide immune booster, comprising: a polypeptide (i) with an amino acid sequence having a length of 30 amino acids contained in the head domain of the fibre protein of the capsid of an adenovirus, said amino acid sequence comprising the sequence of amino acids forming a double ß sheet called EF, contained in said head domain, or a peptide analogue (ii) of said polypeptide (i), the amino acid sequence of which has, by comparison with the sequence of polypeptide (i), at least one substitution or at least one deletion of an amino acid, said analogue peptide conserving the double ß sheet called EF .

公开(公告)号：EP1425295B1

公开(公告)日：2009-12-23

申请号：EP02797690.1

申请日：2002-09-06

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： MULLER, Sylviane ,  MONNEAUX, Fanny ,  BRIAND, Jean-Paul ,  GUICHARD, Gille ,  GUILLET, Jean-Gérard

IPC分类号： C07K2/00 ,  C07K14/00 ,  C07K14/47 ,  A61K38/02 ,  A61K38/16 ,  A61K39/00

CPC分类号： C07K14/47 ,  A61K38/02 ,  A61K38/16 ,  A61K39/0008

摘要： Disclosed herein are a modified peptide, compositions containing the same and their use in the treatment of autoimmune diseases. The modified peptide is provided by a chemical modification of at least one of the several amino acid residues comprising the peptide of sequence RIHMUYSKRSGKPRGYAFIEY (seq ID No : 1). The modification is carried out by phosphorylation, acetylation or methylation, or as a combination thereof.

公开(公告)号：EP0750508A1

公开(公告)日：1997-01-02

申请号：EP95912306.0

申请日：1995-03-13

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： GUICHARD, Gilles ,  MULLER, Sylviane ,  BRIAND, Jean-Paul ,  REGENMORTEL, Marc

IPC分类号： C07K5 ,  C07K7 ,  C07K14 ,  C07K16 ,  A61K38 ,  A61K39

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K39/00 ,  C07K5/0212 ,  C07K7/02 ,  C07K14/47 ,  Y02A50/386

摘要： The invention discloses the use of (1) peptide compounds in which at least one and advantageously all of the -CO-NH- bonds in the peptide chain of the corresponding parent peptide (comprising no -NH-CO- bond in its peptide chain) is (are) replaced with one or more -NH-CO- bonds, the chirality of every aminoacyl residue, whether or not it contributes to the one or more above-mentioned -NH-CO- bonds, being either maintained or reversed relative to the corresponding aminoacyl residues constituting said parent peptide, said peptide compounds also being known as immunoretroids; or (2) antibodies to said immunoretroids (anti-immunoretroid antibodies); said immunoretroids being capable of forming a complex with said anti-immunoretroid antibodies as well as with antibodies to the parent proteins or peptides (known as anti-parent antibodies), and/or to the enantiomers of such parent proteins or peptides; for preparing a drug which is particularly useful for treating or preventing diseases related to the presence in the body of an individual of an exogenous or endogenous protein capable of being recognised by the above-mentioned anti-parent or anti-immunoretroid antibodies.