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公开(公告)号：EP0387915B1
公开(公告)日：1993-03-10
申请号：EP90105190.4
申请日：1985-10-18
发明人： Mongagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Chermann, Jean-Claude , Barre-Sinoussi, Françoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
IPC分类号： C07K15/04 , C12N15/49 , C07K1/00 , C07K3/04 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
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公开(公告)号：EP1231271B1
公开(公告)日：2004-12-29
申请号：EP02008713.6
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, Francois , Chermann, Jean-Claude , Barre-Sinoussi, Francoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1063 , C12N2740/16122 , C12N2740/16222 , C12Q1/702 , G01N33/56983
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公开(公告)号：EP1231271A3
公开(公告)日：2002-10-09
申请号：EP02008713.6
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, Francois , Chermann, Jean-Claude , Barre-Sinoussi, Francoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1063 , C12N2740/16122 , C12N2740/16222 , C12Q1/702 , G01N33/56983
摘要： The invention relates to a DNA fragment hybridizable with genomic RNA of LAV or with LAV cDNA, wherein said DNA fragment is derived from the DNA encoding the gag Open Reading Frame contained between nucleotide positions 312 and 1836 of the nucleic acid of figure 4.
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4.发明公开
公开(公告)号：EP0387915A1
公开(公告)日：1990-09-19
申请号：EP90105190.4
申请日：1985-10-18
发明人： Mongagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Chermann, Jean-Claude , Barre-Sinoussi, Françoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
IPC分类号： C07K15/04 , C12N15/49 , C07K1/00 , C07K3/04 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
摘要： The invention concerns purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.
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5.发明授权Gag antigen and its use for the detection of lav infection and in immunogenic compositions 失效的Gag抗原及其用于检测LAV感染的用途，以及免疫原性组合物
公开(公告)号：EP1279678B1
公开(公告)日：2007-09-12
申请号：EP02017001.5
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Chermann, Jean-Claude , Barre-Sinoussi, Françoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
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公开(公告)号：EP0462627B1
公开(公告)日：2003-09-17
申请号：EP91113062.3
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Chermann, Jean-Claude , Barre-Sinoussi, Françoise , Alizon,Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
IPC分类号： C07K14/16 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
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7.发明公开Cloned DNA sequences, hybridizable with genomic RNA of lymphadenopathy-associated virus (LAV) 失效Klonierte DNS- Sequenzen，hybridisierbar mit Genom-RNS vom“lymphadenopathy-associated virus（LAV）”。
公开(公告)号：EP0178978A1
公开(公告)日：1986-04-23
申请号：EP85401799.3
申请日：1985-09-17
发明人： Alizon, Marc , Barre Sinoussi, Françoise , Sonigo, Pierre , Tiollais, Pierre , Chermann, Jean-Claude , Montagnier, Luc , Wain-Hobson, Simon
CPC分类号： C07K14/005 , C12N2740/16022 , C12Q1/703
摘要： The invention relates to cloned DNAs which contains a DNA fragment hybridizable with the genomic RNA of LAV viruses. They are useful as probes for the in vitro detection of viral infection in biological samples taken from persons possibly afflicted with AIDS.
摘要翻译： 本发明涉及含有可与LAV病毒基因组RNA杂交的DNA片段的克隆DNA。 它们可用作体外检测来自可能患有艾滋病的人的生物样品中的病毒感染的探针。
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公开(公告)号：EP1231271B2
公开(公告)日：2011-06-15
申请号：EP02008713.6
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, Francois , Chermann, Jean-Claude , Barre-Sinoussi, Francoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1063 , C12N2740/16122 , C12N2740/16222 , C12Q1/702 , G01N33/56983
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公开(公告)号：EP0462627B2
公开(公告)日：2011-04-27
申请号：EP91113062.3
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Chermann, Jean-Claude , Barre-Sinoussi, Françoise , Alizon,Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
IPC分类号： C07K14/16 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
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10.发明公开Gag antigen and other orf fragments of lav virus. Use for the detection of lav infection and in immunogenic compositions 失效Gag-Antigen und Dessen Verwendung zum Nachweis von LAV-Infektion，sowie in immunogenen Zusammensetzungen
公开(公告)号：EP1279678A1
公开(公告)日：2003-01-29
申请号：EP02017001.5
申请日：1985-10-18
发明人： Montagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Cherman, Jean-Claude , Barre-Sinoussi, Françoise , Alizon, Marc , Sonige, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
摘要： The invention relates to GAG antigens of the LAV virus, to fragments of said antigens and to nucleotide sequence encoding them. It further concerns other Open Reading Frame fragments of LAV virus.
It relates further to their use in diagnosis kits and in immunogenic compositions.摘要翻译： 本发明涉及LAV病毒的GAG抗原，所述抗原的片段和编码它们的核苷酸序列。 它还涉及LAV病毒的其他开放阅读框架片段。 它进一步涉及它们在诊断试剂盒和免疫原性组合物中的应用。
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