摘要:
The invention relates to cloned DNAs which contains a DNA fragment hybridizable with the genomic RNA of LAV viruses. They are useful as probes for the in vitro detection of viral infection in biological samples taken from persons possibly afflicted with AIDS.
摘要:
On a utilisé un sel alcalin et/ou alcalino-terreux et/ou d'ammonium de l'hétéropolyanion (NaSb 2 W 21 O 86 ) 18 éventuellement sous une forme hydrate, pour fabriquer une composition destinée au traitement du SIDA et des syndromes analogues. La composition pharmaceutique comprend au moins un médicament tel que défini ci-dessus en association avec un ou plusieurs diluants ou adjuvants compatibles et pharmaceutiquement acceptables. L'administration est parentérale, intralymphatique, orale ou rectale. L'administration est notamment parentérale, de préférence. intraveineuse. La dose unitaire est, dans tous les cas, comprise entre 0, 1 et 100 mg par kilo de poids corporel et par jour.
摘要:
The invention relates to a DNA fragment hybridizable with genomic RNA of LAV or with LAV cDNA, wherein said DNA fragment is derived from the DNA encoding the gag Open Reading Frame contained between nucleotide positions 312 and 1836 of the nucleic acid of figure 4.
摘要:
The invention concerns purified expression products of DNA sequences derived of the genome of the LAV virus. It relates more particularly to a glycoprotein having a molecular weight of about 110,000 or antigen of lower molecular weight derived from the preceding one, which purified product possesses the capacity of being recognised by serums of human origin and containing antibodies against the LAV virus. It also relates to other purified polypeptides derived either from the abovesaid glycoprotein or of core proteins of LAV virus. The glycoprotein can be used for the production of immunogenic composition capable of neutralizing the LAV virus. All of the abovesaid glycoprotein or polypeptides can be used as antigens useful in the diagnosis of LAV antibodies in sera of patients.