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公开(公告)号：EP0330878A2
公开(公告)日：1989-09-06
申请号：EP89102192.5
申请日：1989-02-09
IPC分类号： C07K7/00 , C07K17/00 , C07K17/08 , C07K3/04 , C12P21/00 , G01N33/577 , G01N33/535 , C07K3/20
摘要： The invention relates to polypeptides wlth amino acid sequences spanning position 61 of the normal and the mutant ras proteins, their preparation, the utilization of such polypeptides to prepare immunogenic compositions utilizing such polypeptides covalently linked to immunogenic carrier materials, the production of antibodies elicited by such polypeptides, and to immunoassays and the use of immunochemical methods employing such antibodies to determine the presence of the p21TLeu61 transforming protein.
摘要翻译： 本发明涉及跨越正常和突变ras蛋白的位置61的第十六个氨基酸序列的多肽，其制备，利用这些多肽来制备利用与免疫原性载体材料共价连接的这种多肽的免疫原性组合物，产生由其引发的抗体 多肽，以及免疫测定和使用采用这种抗体的免疫化学方法来确定p21TLeu61转化蛋白的存在。
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公开(公告)号：EP0387915B1
公开(公告)日：1993-03-10
申请号：EP90105190.4
申请日：1985-10-18
发明人： Mongagnier, Luc , Krust, Bernard , Chamaret, Solange , Clavel, François , Chermann, Jean-Claude , Barre-Sinoussi, Françoise , Alizon, Marc , Sonigo, Pierre , Stewart, Cole , Danos, Olivier , Wain-Hobson, Simon
IPC分类号： C07K15/04 , C12N15/49 , C07K1/00 , C07K3/04 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/1054 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/702 , C12Q1/703 , G01N33/531
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公开(公告)号：EP0307480A4
公开(公告)日：1989-05-16
申请号：EP88902561
申请日：1988-03-17
申请人： TEIJIN LTD
发明人： ENDO NORIAKI , TAKEDA YUMIKO , KATO YOSHINORI , HARA TAKESHI
IPC分类号： G01N33/531 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , C07K1/107 , C07K1/113 , C07K14/00 , C07K16/00 , C07K15/12 , C07K3/04 , C07K3/08 , C07K17/10 , C12Q1/00 , G01N33/532
CPC分类号： A61K39/395 , A61K47/68 , A61K47/6887 , A61K47/6889
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公开(公告)号：EP0598899A4
公开(公告)日：1995-08-16
申请号：EP93916581
申请日：1993-06-16
申请人： SIWRUK GARY A , EYNON JOHN S
发明人： SIWRUK GARY A , EYNON JOHN S
CPC分类号： C07K5/1013 , C07K1/02 , C07K1/064 , Y02P20/55
摘要： A liquid phase peptide synthetic method which uses (1) Fmoc as the protecting group for the non-side chain amino functionality, (2) ammonia, a primary or secondary amine to remove the Fmoc protecting group, and (3) substituted carbodiimide as the coupling agent for the C to N synthesis of peptides or peptide derivatives in a proper organic solvent.
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5.发明公开Streptolysin O Peptidantigene und Verfahren zur Bestimmung von Streptolysin-Antikörper 失效链球菌溶血素ø肽抗原，以及用于判定链球菌溶血素抗体的方法。
公开(公告)号：EP0600326A2
公开(公告)日：1994-06-08
申请号：EP93118697.7
申请日：1993-11-20
CPC分类号： C07K14/315 , A61K39/00 , Y10S436/804
摘要： Es werden SLO Peptidantigene beschrieben. Diese Peptidantigene sind zur Bestimmung von SLO-Antikörpern, als Immunogene zur Herstellung von Antikörpern gegen SLO und als Vakzine zur Herstellung von Impfstoffen gegen SLO geeignet.
摘要翻译： 它描述肽抗原SLO。 这些肽抗原适用于SLO抗体的测定，作为免疫原用于产生抗体的SLO和作为用于产生抗SLO疫苗的疫苗。
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公开(公告)号：EP0374157A4
公开(公告)日：1990-09-05
申请号：EP88905520
申请日：1988-05-31
发明人： KIM, SUNG-HOU
IPC分类号： C12N15/09 , A23L27/30 , C07K1/04 , C07K1/22 , C07K14/00 , C07K14/415 , C07K14/43 , C07K19/00 , C12N1/21 , C12N15/29 , C12N15/82 , C12P21/02 , C12R1/19 , C07K1/06 , A23L1/236 , C07H21/04 , C07K3/04 , C07K7/10 , C07K13/00 , C12N1/20
CPC分类号： C12N15/8242 , C07K14/43
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公开(公告)号：EP0635025A4
公开(公告)日：1997-02-26
申请号：EP93909180
申请日：1993-03-26
IPC分类号： C07K1/04 , C07K1/06 , C07K1/10 , C07K1/107 , C07K1/113 , C07K7/02 , C07K14/16 , C12N9/50 , C07K3/04
CPC分类号： C07K14/005 , C07K1/04 , C07K1/1075 , C07K1/1077 , C07K7/02 , C12N9/506 , C12N2740/16222 , Y02P20/582
摘要： Process for the preparation of modified proteins comprising the coupling of a first peptide segment having a haloacyl group at the N-terminus thereof with a second peptide segment having a carbonylthiol group at the C-terminus thereof are disclosed. Novel modified proteins produced by the process are also disclosed.
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公开(公告)号：EP0374157B1
公开(公告)日：1994-07-06
申请号：EP88905520.8
申请日：1988-05-31
发明人： KIM, Sung-Hou , Cho, Joong Myung
CPC分类号： C12N15/8242 , C07K14/43
摘要： Single-chain analogs of the naturally occurring two chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linker joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.
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公开(公告)号：EP0539491A4
公开(公告)日：1994-03-23
申请号：EP91913697
申请日：1991-07-15
IPC分类号： A61K38/22 , A61K38/00 , A61P3/00 , C07K14/635 , C07K3/04
CPC分类号： C07K14/635 , A61K38/00
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公开(公告)号：EP0498801A4
公开(公告)日：1993-03-31
申请号：EP90913430
申请日：1990-09-13
CPC分类号： C07K1/042 , B01J19/0046 , B01J2219/00504 , B01J2219/00506 , B01J2219/0059 , B01J2219/00596 , B01J2219/00725 , C40B40/10
摘要： There is disclosed a solid surface, such as the surface of a rod or pin, for use in the synthesis of polymeric compounds such as peptides. The surface comprises an active region and an inactive region being positioned such that, in use, it is below the surface of the reaction liquid in a reaction well, irrespective of minor variations in liquid levels between various wells so as to eliminate the formation of deletion compounds. There are further described such surfaces for the formation of relatively large quantities of compound wherein the active region has a higher surface area/volume ratio than that of a cylinder of corresponding volume.
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