公开(公告)号：EP1846580A2

公开(公告)日：2007-10-24

申请号：EP06784314.4

申请日：2006-02-06

申请人： IRM, LLC

发明人： CALDWELL, Jeremy ,  NGUYEN, Deborah ,  KUHEN, Kelli L.

IPC分类号： C12Q1/70 ,  C12N7/00 ,  C12N7/01

CPC分类号： C12Q1/703

摘要： This invention provides novel methods for identifying agents that inhibit HIV infection. The anti-HIV agents are identified by screening test compounds for ability to down-regulate the kinase activity or the expression of a PAK3 molecule. Such PAK3 modulators can be further examined for their activity in inhibiting HIV infection. These novel anti-HIV agents are useful in the prevention or treatment of HIV infection and conditions associated with HIV infection.

公开(公告)号：EP1957975A2

公开(公告)日：2008-08-20

申请号：EP06848507.7

申请日：2006-12-08

申请人： IRM, LLC

发明人： NGUYEN, Deborah ,  KUHEN, Kelli ,  CALDWELL, Jeremy

IPC分类号： G01N33/50

CPC分类号： C12Q1/6897 ,  C12Q1/18 ,  G01N33/56988 ,  G01N2333/161 ,  G01N2500/00

摘要： This invention provides novel HIV-interacting host factors. The invention also provides methods of using the HIV-interacting host factors to screen for compounds that inhibit HIV infection. The methods comprise first screening test compounds for modulators of an HIV-interacting host factor disclosed herein, and then further screening the identified modulating compounds for ability to inhibit HIV infection. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with HIV infection.