公开(公告)号：EP2274302A2

公开(公告)日：2011-01-19

申请号：EP09727043.3

申请日：2009-03-30

申请人： IRM LLC

发明人： WAN, Yongqin ,  PAN, Shifeng ,  ZHANG, Guobao ,  WANG, Xia ,  XIE, Yun Feng ,  JIANG, Jiqing ,  PHILLIPS, Dean ,  YANG, Yang

IPC分类号： C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D471/04 ,  A61K31/496 ,  A61P17/00 ,  A61P19/00

CPC分类号： C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D471/04

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).

公开(公告)号：EP2057124A2

公开(公告)日：2009-05-13

申请号：EP07799749.2

申请日：2007-07-20

申请人： IRM, LLC

发明人： PAN, Shifeng ,  LIU, Yi ,  XIE, Yun Feng ,  CHENG, Dai ,  WAN, Yongqin ,  HAN, Dong ,  YANG, Yang ,  GAO, Wenqi ,  JIANG, Jiqing ,  BURSULAYA, Badry ,  CHAMBERLAIN, Philip ,  KARANEWSKY, Donald S. ,  WANG, Xia

IPC分类号： C07D231/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D491/048 ,  A61K31/415 ,  A61K31/44 ,  A61P17/00 ,  A61P19/02

CPC分类号： C07D401/12 ,  C07D231/12 ,  C07D401/14 ,  C07D413/14 ,  C07D487/08 ,  C07D491/04

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5-trisphosphate 3-kinase B (ITPKb).

公开(公告)号：EP2328871A2

公开(公告)日：2011-06-08

申请号：EP09791850.2

申请日：2009-08-24

申请人： IRM LLC

发明人： CHENG, Dai ,  HAN, Dong ,  ZHANG, Guobao ,  WAN, Yongqin ,  XIE, Yun Feng ,  JIANG, Jiqing ,  GAO, Wenqi ,  PAN, Shifeng

IPC分类号： C07D217/04 ,  C07D217/08 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D473/00 ,  C07D487/04 ,  C07D513/04 ,  A61K31/47

摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

摘要翻译： 本发明提供了一种调节刺猬蛋白信号通路活性的方法，化合物和组合物。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触 与足量的式（I）化合物反应。