公开(公告)号：EP1628967B1

公开(公告)日：2014-04-09

申请号：EP04752679.3

申请日：2004-05-19

申请人： IRM LLC

发明人： MI, Yuan ,  PAN, Shifeng ,  GRAY, Nathanael, S. ,  GAO, Wenqi ,  FAN, Yi ,  JIANG, Tao

IPC分类号： C07D413/10 ,  A61K31/4725 ,  C07D333/58 ,  C07D409/06 ,  C07D471/04 ,  C07D473/00 ,  C07D261/20 ,  C07D513/04

CPC分类号： C07D333/58 ,  C07D261/20 ,  C07D409/06 ,  C07D471/04 ,  C07D473/00 ,  C07D513/04

公开(公告)号：EP2588453A1

公开(公告)日：2013-05-08

申请号：EP11733945.7

申请日：2011-06-28

申请人： IRM LLC ,  Novartis AG

发明人： CHENG, Dai ,  ZHANG, Guobao ,  HAN, Dong ,  GAO, Wenqi ,  PAN, Shifeng ,  SHEN, Lichun ,  LELETI, Rajender Reddy

IPC分类号： C07D213/56 ,  C07D237/08 ,  C07D279/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  A61K31/44 ,  A61P35/00

CPC分类号： C07D417/14 ,  A61K31/50 ,  A61K31/541 ,  A61K45/06 ,  C07D213/56 ,  C07D237/08 ,  C07D279/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R
1 , R
2 , R
3 are as defined herein.

公开(公告)号：EP2170867A1

公开(公告)日：2010-04-07

申请号：EP08770592.7

申请日：2008-06-10

申请人： IRM LLC

发明人： HUANG, Shenlin ,  LIU, Zuosheng ,  ALBAUGH, Pamela, A. ,  WANG, Xing ,  PAN, Shifeng ,  XIE, Yongping ,  ZHANG, Guobao

IPC分类号： C07D401/14 ,  C07D403/04

CPC分类号： C07D401/14 ,  C07D403/04

摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, CSK, C-Src, EphB1, EphB2, EphB4, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFRβ, PKCα, SAPK2α, Src, SIK, Syk, Tie2 and TrkB kinases.

公开(公告)号：EP1628967A1

公开(公告)日：2006-03-01

申请号：EP04752679.3

申请日：2004-05-19

申请人： IRM LLC

发明人： MI, Yuan ,  PAN, Shifeng ,  GRAY, Nathanael, S. ,  GAO, Wenqi ,  FAN, Yi ,  JIANG, Tao

IPC分类号： C07D333/60

CPC分类号： C07D333/58 ,  C07D261/20 ,  C07D409/06 ,  C07D471/04 ,  C07D473/00 ,  C07D513/04

摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

公开(公告)号：EP2403832B1

公开(公告)日：2013-11-20

申请号：EP10708670.4

申请日：2010-03-01

申请人： IRM LLC

发明人： CHENG, Dai ,  ZHANG, Guobao ,  HAN, Dong ,  GAO, Wenqi ,  PAN, Shifeng

IPC分类号： C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/44 ,  A61P35/00

CPC分类号： A61K31/541 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway.

公开(公告)号：EP1594508B1

公开(公告)日：2012-08-08

申请号：EP04710227.2

申请日：2004-02-11

申请人： IRM LLC

发明人： PAN, Shifeng ,  GRAY, Nathanael ,  MI, Yuan ,  GAO, Wenqi ,  FAN, Yi ,  LEFEBVRE, Sophie

IPC分类号： A61K31/537 ,  A61K31/421 ,  A61K31/277 ,  A61K31/15 ,  A61K31/18 ,  A61K31/42

CPC分类号： C07D213/30 ,  C07C251/48 ,  C07C251/52 ,  C07C251/54 ,  C07D307/42 ,  C07D333/16 ,  C07F9/094 ,  C07F9/655345

摘要： The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.

公开(公告)号：EP1928236B1

公开(公告)日：2011-11-23

申请号：EP06815653.8

申请日：2006-09-26

申请人： IRM LLC ,  Novartis AG

发明人： MOLTENI, Valentina ,  LI, Xiaolin ,  CHIANELLI, Donatella ,  LOREN, Jon ,  LIU, Yi ,  KARANEWSKY, Donald, S. ,  FURET, Pascal ,  GUAGNANO, Vito ,  YOU, Shuli ,  NABAKKA, Juliet ,  LIU, Xiaodong ,  PAN, Shifeng

IPC分类号： A01N43/42 ,  A61K31/44

CPC分类号： C07D403/04 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D491/10

摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

公开(公告)号：EP2274302A2

公开(公告)日：2011-01-19

申请号：EP09727043.3

申请日：2009-03-30

申请人： IRM LLC

发明人： WAN, Yongqin ,  PAN, Shifeng ,  ZHANG, Guobao ,  WANG, Xia ,  XIE, Yun Feng ,  JIANG, Jiqing ,  PHILLIPS, Dean ,  YANG, Yang

IPC分类号： C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D471/04 ,  A61K31/496 ,  A61P17/00 ,  A61P19/00

CPC分类号： C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D471/04

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).

公开(公告)号：EP2167498A1

公开(公告)日：2010-03-31

申请号：EP08770796.4

申请日：2008-06-12

申请人： IRM LLC

发明人： BURSULAYA, Badry ,  CHENG, Dai ,  JIANG, Jiqing ,  KARANEWSKY, Donald, S. ,  LIU, Yi ,  PAN, Shifeng ,  WAN, Yongqin ,  WANG, Xia ,  XIE, Yun, Feng ,  YANG, Yang

IPC分类号： C07D413/14 ,  C07D413/02 ,  A61K31/536 ,  A61P37/02

CPC分类号： C07D413/14 ,  C07D413/02

摘要： The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5- trisphosphate 3 -kinase B (ITPKb).

摘要翻译： 本发明提供了一类新的式（I）化合物，包含这些化合物的药物组合物以及使用这些化合物治疗或预防与B细胞活性异常或失调相关的疾病或病症，特别是涉及异常活化 肌醇1,4,5-三磷酸3-激酶B（ITPKb）。

公开(公告)号：EP2057124A2

公开(公告)日：2009-05-13

申请号：EP07799749.2

申请日：2007-07-20

申请人： IRM, LLC

发明人： PAN, Shifeng ,  LIU, Yi ,  XIE, Yun Feng ,  CHENG, Dai ,  WAN, Yongqin ,  HAN, Dong ,  YANG, Yang ,  GAO, Wenqi ,  JIANG, Jiqing ,  BURSULAYA, Badry ,  CHAMBERLAIN, Philip ,  KARANEWSKY, Donald S. ,  WANG, Xia

IPC分类号： C07D231/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D491/048 ,  A61K31/415 ,  A61K31/44 ,  A61P17/00 ,  A61P19/02

CPC分类号： C07D401/12 ,  C07D231/12 ,  C07D401/14 ,  C07D413/14 ,  C07D487/08 ,  C07D491/04

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5-trisphosphate 3-kinase B (ITPKb).