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公开(公告)号：EP2588453A1
公开(公告)日：2013-05-08
申请号：EP11733945.7
申请日：2011-06-28
申请人： IRM LLC , Novartis AG
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng , SHEN, Lichun , LELETI, Rajender Reddy
IPC分类号： C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12 , A61K31/44 , A61P35/00
CPC分类号： C07D417/14 , A61K31/50 , A61K31/541 , A61K45/06 , C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R
1 , R
2 , R
3 are as defined herein.-
2.发明公开COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY 审中-公开化合物和组合物受体酪氨酸激酶活性的抑制剂
公开(公告)号：EP1656378A2
公开(公告)日：2006-05-17
申请号：EP04781114.6
申请日：2004-08-13
申请人： IRM LLC
发明人： CHENG, Dai , DING, Qiang , HAN, Dong , GRAY, Nathanael Schiander , ZHANG, Guobao
IPC分类号： C07D473/40 , C07D473/34 , C07D473/18 , C07D473/16 , A61K31/52 , A61K31/522 , A61P35/02 , A61P35/00 , A61P9/10 , A61P17/06 , A61P11/06
CPC分类号： C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFRα kinase activity.
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3.发明授权N-(HETERO)ARYL,2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 有权N-（杂）芳基，2-（杂）芳基 - 取代的乙酰胺用作WNT信号切换的调节剂
公开(公告)号：EP2403832B1
公开(公告)日：2013-11-20
申请号：EP10708670.4
申请日：2010-03-01
申请人： IRM LLC
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng
IPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/44 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway.
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4.发明公开PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES 审中-公开嘌呤化合物和作为激酶抑制剂的组合物与相关方疟原虫疾病中治疗
公开(公告)号：EP2124954A2
公开(公告)日：2009-12-02
申请号：EP08727555.8
申请日：2008-01-10
发明人： WINZELER, Elizabeth , GRAY, Nathanael S. , HAN, Dong , CHENG, Dai
IPC分类号： A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/662 , A61K45/06 , A61P33/06 , C07D473/16 , C07D473/18 , C07D473/34
CPC分类号： A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/662 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D417/14 , Y02A50/411
摘要： The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with kinase activity, particularly malaria.
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公开(公告)号：EP2057124A2
公开(公告)日：2009-05-13
申请号：EP07799749.2
申请日：2007-07-20
申请人： IRM, LLC
发明人： PAN, Shifeng , LIU, Yi , XIE, Yun Feng , CHENG, Dai , WAN, Yongqin , HAN, Dong , YANG, Yang , GAO, Wenqi , JIANG, Jiqing , BURSULAYA, Badry , CHAMBERLAIN, Philip , KARANEWSKY, Donald S. , WANG, Xia
IPC分类号： C07D231/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D491/048 , A61K31/415 , A61K31/44 , A61P17/00 , A61P19/02
CPC分类号： C07D401/12 , C07D231/12 , C07D401/14 , C07D413/14 , C07D487/08 , C07D491/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5-trisphosphate 3-kinase B (ITPKb).
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公开(公告)号：EP2328871A2
公开(公告)日：2011-06-08
申请号：EP09791850.2
申请日：2009-08-24
申请人： IRM LLC
发明人： CHENG, Dai , HAN, Dong , ZHANG, Guobao , WAN, Yongqin , XIE, Yun Feng , JIANG, Jiqing , GAO, Wenqi , PAN, Shifeng
IPC分类号： C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D473/00 , C07D487/04 , C07D513/04 , A61K31/47
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译： 本发明提供了一种调节刺猬蛋白信号通路活性的方法，化合物和组合物。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触 与足量的式（I）化合物反应。
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公开(公告)号：EP2044065A2
公开(公告)日：2009-04-08
申请号：EP07840497.7
申请日：2007-07-24
申请人： IRM, LLC
发明人： CHENG, Dai , HAN, Dong , GAO, Wenqi , JIANG, Jiqing , PAN, Shifeng , WAN, Yongqin , JIN, Qihui
IPC分类号： C07D413/14 , C07D401/12 , C07D233/64 , C07D471/04 , A61K31/4709 , A61K31/4164 , A61K31/5377 , A61K31/55 , A61P35/00 , A61P17/06
CPC分类号： C07D413/14 , C07D233/64 , C07D401/12 , C07D471/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译： 本发明提供了调节刺猬蛋白信号传导途径活性的方法。 具体而言，本发明提供了抑制由表型如Ptc功能缺失，刺猬功能获得，平滑功能获得或Gli功能获得引起的异常生长状态的方法，包括使细胞 与足量的式I化合物接触。
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8.发明公开COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS 有权VERBINDUNGEN UND ZUSAMMENSETZUNGEN ALS HEDGEHOG-WEGMODULATOREN
公开(公告)号：EP2021328A2
公开(公告)日：2009-02-11
申请号：EP07761921.1
申请日：2007-05-04
申请人： IRM LLC
发明人： GAO, Wenqi , JIANG, Jiqing , WAN, Yongqin , CHENG, Dai , HAN, Dong , WU, Xu , PAN, Shifeng
IPC分类号： C07D213/75
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-furiction or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译： 本发明提供了一种调节刺猬蛋白信号通路活性的方法。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或Gli功能增益引起的表型的异常生长状态的方法，包括使细胞接触 与足量的式I的化合物反应。
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公开(公告)号：EP2021328B1
公开(公告)日：2013-04-03
申请号：EP07761921.1
申请日：2007-05-04
申请人： IRM LLC
发明人： GAO, Wenqi , JIANG, Jiqing , WAN, Yongqin , CHENG, Dai , HAN, Dong , WU, Xu , PAN, Shifeng
IPC分类号： C07D413/04
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
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10.发明公开N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 有权N-（杂）芳基，2-（杂）芳基 - 取代的乙酰胺用作WNT信号切换的调节剂
公开(公告)号：EP2403832A1
公开(公告)日：2012-01-11
申请号：EP10708670.4
申请日：2010-03-01
申请人： IRM LLC
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng
IPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/44 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway.
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