公开(公告)号：EP1804803A2

公开(公告)日：2007-07-11

申请号：EP05815083.0

申请日：2005-10-28

申请人： IRM, LLC ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： WU, Xu ,  DING, Sheng ,  SCHULTZ, Peter, G.

IPC分类号： A61K31/542 ,  A61K31/437 ,  A61K31/435

CPC分类号： A61K31/427 ,  A61K31/435 ,  A61K31/437

摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

公开(公告)号：EP1556129A2

公开(公告)日：2005-07-27

申请号：EP03809017.1

申请日：2003-10-15

申请人： IRM LLC ,  The Scripps Research Institute

发明人： WU, Xu ,  DING, Sheng ,  GRAY, Nathanael, S.

IPC分类号： A61N1/00

CPC分类号： C07D473/16 ,  C07D473/18 ,  C07D473/34 ,  C07D473/40

摘要： The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage.

公开(公告)号：EP1727806A1

公开(公告)日：2006-12-06

申请号：EP05700922.7

申请日：2005-01-14

申请人： Novartis AG ,  Novartis Pharma GmbH ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： WU, Xu ,  DING, Sheng ,  SCHULTZ, Peter, G.

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506

CPC分类号： C07D239/48 ,  C07D403/12 ,  C07D405/12

摘要： The present invention provides compounds of formula (I) useful for inducing cardiomyogenesis in mammalian cells, particularly embryonic stem cells, in vitro and in vivo.

公开(公告)号：EP2459558A2

公开(公告)日：2012-06-06

申请号：EP10747541.0

申请日：2010-07-30

申请人： IRM LLC

发明人： CHE, Jianwei ,  DING, Qiang ,  HE, Xiaohui ,  LIU, Hong ,  LIU, Yahua ,  MICHELLYS, Pierre-Yves ,  OKRAM, Barun ,  WU, Xu ,  YANG, Kunyong ,  ZHU, Xuefeng

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

公开(公告)号：EP2250169A1

公开(公告)日：2010-11-17

申请号：EP09708389.3

申请日：2009-01-27

申请人： IRM LLC

发明人： DING, Qiang ,  LIU, Yahua ,  WU, Xu ,  JIN, Qihui ,  CHE, Jianwei ,  YAN, S. Frank

IPC分类号： C07D471/04 ,  A61K31/519

CPC分类号： C07D471/04

摘要： The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.

公开(公告)号：EP2021328A2

公开(公告)日：2009-02-11

申请号：EP07761921.1

申请日：2007-05-04

申请人： IRM LLC

发明人： GAO, Wenqi ,  JIANG, Jiqing ,  WAN, Yongqin ,  CHENG, Dai ,  HAN, Dong ,  WU, Xu ,  PAN, Shifeng

IPC分类号： C07D213/75

CPC分类号： C07C255/57 ,  C07C235/56 ,  C07C237/40 ,  C07C2601/14 ,  C07D413/04

摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-furiction or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

摘要翻译： 本发明提供了一种调节刺猬蛋白信号通路活性的方法。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或Gli功能增益引起的表型的异常生长状态的方法，包括使细胞接触 与足量的式I的化合物反应。

公开(公告)号：EP2162190A1

公开(公告)日：2010-03-17

申请号：EP08770130.6

申请日：2008-06-04

申请人： IRM LLC

发明人： DIERKS, Christine ,  WARMUTH, Markus ,  WU, Xu

IPC分类号： A61P35/00 ,  A61K31/165 ,  A61K31/18 ,  A61K31/277 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551

CPC分类号： A61K31/165 ,  A61K31/18 ,  A61K31/277 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553

摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

公开(公告)号：EP2021328B1

公开(公告)日：2013-04-03

申请号：EP07761921.1

申请日：2007-05-04

申请人： IRM LLC

发明人： GAO, Wenqi ,  JIANG, Jiqing ,  WAN, Yongqin ,  CHENG, Dai ,  HAN, Dong ,  WU, Xu ,  PAN, Shifeng

IPC分类号： C07D413/04

CPC分类号： C07C255/57 ,  C07C235/56 ,  C07C237/40 ,  C07C2601/14 ,  C07D413/04

公开(公告)号：EP2459556A1

公开(公告)日：2012-06-06

申请号：EP10737729.3

申请日：2010-07-27

申请人： IRM LLC

发明人： CHE, Jianwei ,  CHEN, Bei ,  DING, Qiang ,  HAO, Xueshi ,  HE, Xiaohui ,  JIANG, Songchun ,  JIN, Qihui ,  JIN, Yunho ,  LIU, Hong ,  LIU, Yahua ,  OKRAM, Barun ,  UNO, Tetsuo ,  WU, Xu ,  YANG, Kunyong ,  ZHU, Xuefeng

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D471/04 ,  A61K31/4375

摘要： Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

公开(公告)号：EP2238137A1

公开(公告)日：2010-10-13

申请号：EP09705446.4

申请日：2009-01-27

申请人： IRM LLC

发明人： OKRAM, Barun ,  UNO, Tetsuo ,  DING, Qiang ,  LIU, Yahua ,  JIN, Yunho ,  JIN, Qihui ,  WU, Xu ,  CHE, Jianwei ,  YAN, S. Frank ,  HAO, Xueshi

IPC分类号： C07D471/04 ,  A61K31/4375

CPC分类号： C07D471/04

摘要： The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity,particulary Syk,ZAP70,KDR,FMS,FLT*,c-Kit,RET,TrkA,TrkB,TrkC-GR-1R,Alk,c- FMS.or combinations thereof.