公开(公告)号：EP0656790A1

公开(公告)日：1995-06-14

申请号：EP93907292.0

申请日：1993-03-05

申请人： ISIS PHARMACEUTICALS, INC.

发明人： COOK, Phillip Dan ,  BRUICE, Thomas ,  GUINOSSO, Charles John ,  KAWASAKI, Andrew Mamoru ,  GRIFFEY, Richard

IPC分类号： A61K31 ,  A61K48 ,  A61P31 ,  A61P43 ,  C07H19 ,  C07H21 ,  C07H23 ,  C07J43 ,  C07K14 ,  C12N9 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H23/00 ,  C07J43/003 ,  C07K14/005 ,  C12N9/0069 ,  C12N15/1137 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/333 ,  C12N2310/336 ,  C12N2310/3511 ,  C12N2310/3521 ,  C12N2310/3523 ,  C12N2310/3527 ,  C12N2310/3531 ,  C12N2310/3533 ,  C12N2740/16322 ,  C12Q1/68 ,  C12Q1/6813 ,  C12Y113/11012

摘要： Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.