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1.发明公开
公开(公告)号：EP1660682A2
公开(公告)日：2006-05-31
申请号：EP04781089.0
申请日：2004-08-12
发明人： MONIA, Brett P. , DOBIE, Kenneth W. , FREIER, Susan M. , POPOFF, Ian , WONG, Wai Shiu Fred , KARRAS, James G.
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
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2.发明授权
公开(公告)号：EP1660682B1
公开(公告)日：2011-10-05
申请号：EP04781089.0
申请日：2004-08-12
发明人： MONIA, Brett P. , DOBIE, Kenneth W. , FREIER, Susan M. , POPOFF, Ian , WONG, Wai Shiu Fred , KARRAS, James G.
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
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公开(公告)号：EP2906697A1
公开(公告)日：2015-08-19
申请号：EP13847099.2
申请日：2013-10-15
发明人： BENNETT, C. Frank , FREIER, Susan M. , ROTHSTEIN, Jeffrey D. , DONNELLY, Christopher , SATTLER, Rita, G.
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12N2310/3521
摘要： Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
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4.发明授权ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 有权反义寡核苷酸指导连接组织生长因子及其应用
公开(公告)号：EP2331141B1
公开(公告)日：2016-01-06
申请号：EP09819622.3
申请日：2009-08-25
发明人： DEAN, Nicholas, M. , FOULKES, J. Gordon , O`DONNELL, Niall , BENNETT, C. Frank , FREIER, Susan M.
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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公开(公告)号：EP2758533A1
公开(公告)日：2014-07-30
申请号：EP12834215.1
申请日：2012-09-20
发明人： FREIER, Susan M. , BHANOT, Sanjay
IPC分类号： C12N15/113 , A61P3/08 , A61P3/10 , A61P7/12
CPC分类号： C12N15/1138 , A61K31/711 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of GCGR mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate metabolic disease, for example, diabetes, or a symptom thereof.
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6.发明公开ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 有权AGAINST THE结缔组织生长因子的前瞻性反义寡核苷酸及其用途
公开(公告)号：EP2331141A2
公开(公告)日：2011-06-15
申请号：EP09819622.3
申请日：2009-08-25
发明人： DEAN, Nicholas, M. , FOULKES, J. Gordon , O`DONNELL, Niall , BENNETT, C. Frank , FREIER, Susan M.
IPC分类号： A61K48/00
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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公开(公告)号：EP2102340A2
公开(公告)日：2009-09-23
申请号：EP07862213.1
申请日：2007-11-27
发明人： FREIER, Susan M. , CROOKE, Rosanne M. , GRAHAM, Mark J. , TARBET, Kristina Lemonidis , BHANOT, Sanjay , TRIBBLE, Diane , WATTS, Andrew T.
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , A01K2227/105 , A01K2267/0375 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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公开(公告)号：EP0670897A1
公开(公告)日：1995-09-13
申请号：EP93923190.0
申请日：1993-10-01
CPC分类号： C07K14/82 , A61K38/00 , C12N2310/322 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2525/125
摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from the human ras gene, having nucleotide units sufficient in identity and number to effect such specific hybridization. Oligonucleotides specifically hybridizable with human H-ras and human Ki-ras are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the activated ras gene. Methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras or Ki-ras gene are also disclosed.
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公开(公告)号：EP2771463A1
公开(公告)日：2014-09-03
申请号：EP12843053.5
申请日：2012-10-25
发明人： FREIER, Susan M. , BHANOT, Sanjay
CPC分类号： C12N15/1138 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K45/06 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of GCCR mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate metabolic disease, for example, diabetes, or a symptom thereof.
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10.发明公开MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION 审中-公开转录3的信号转换器和活化剂调制（STAT3）的表达
公开(公告)号：EP2697243A2
公开(公告)日：2014-02-19
申请号：EP12763390.7
申请日：2012-03-30
CPC分类号： C12N15/113 , C07H21/00 , C07H21/04 , C12N15/00 , C12N15/11 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
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