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    PROCEDE DE SEPARATION AVEC DES ZONES CHROMATOGRAPHIQUES A LONGUEUR VARIABLE
    1.
    发明授权
    PROCEDE DE SEPARATION AVEC DES ZONES CHROMATOGRAPHIQUES A LONGUEUR VARIABLE 有权
    可变长度的色谱区分离工艺

    公开(公告)号：EP1128881B1

    公开(公告)日：2005-06-08

    申请号：EP99950884.9

    申请日：1999-10-29

    申请人： Institut Français du Pétrole ,  Novasep

    发明人： BAILLY, Michel ,  ADAM, Philippe ,  LUDEMANN-HOMBOURGER, Olivier ,  NICOUD, Roger, Marc

    IPC分类号： B01D15/02

    CPC分类号： B01D15/1828 ,  B01D2215/023

    摘要： The invention concerns a method for separating at least a constituent of a mixture in a set of looping chromatographic columns, the loop comprising at least a point for injecting a load, a point for drawing off the raffinate, a point for injecting an eluting agent and a point for drawing of the extract. The method consists in: determining between an injection point and a drawing off point or vice-versa a chromatographic zone and at the end of a specific time interval, the whole set of injection points and drawing off points are offset by the same number of columns or column sections and advantageously from one column or one column section in a specific direction defined with respect to that of the flow of the main fluid circulating through the loop. During said time interval, the offsetting of the different injection and drawing off points of at least one column or column section is carried out at different times such that the length of the zones defined by the different points varies. The invention is useful in particular for separating stereoisomers for pharmaceutical purposes.

    PROCEDE DE SEPARATION SEQUENCE MULTICOLONNES
    4.
    发明公开
    PROCEDE DE SEPARATION SEQUENCE MULTICOLONNES 有权
    方法的顺序多柱分离的

    公开(公告)号：EP2040811A2

    公开(公告)日：2009-04-01

    申请号：EP07788903.8

    申请日：2007-06-18

    申请人： Groupe Novasep

    发明人： THEOLEYRE, Marc-André ,  BAUDOUIN, Stanislas ,  MERRIEN, Annick ,  VALERY, Eric ,  LUDEMANN-HOMBOURGER, Olivier ,  DAVID, Laurent ,  HOLZER, Margit

    IPC分类号： B01D15/18

    CPC分类号： B01D15/1871 ,  B01D15/1828 ,  B01D15/361 ,  B01D15/3804

    摘要： The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow means being placed between adjacent zones and between the last zone and the first zone, this process comprising several sequences, each sequence comprising at least one step chosen from an absorption step, a rinsing step and a desorption step, carried out either simultaneously or not, each following sequence is carried out by the displacement of the fronts in the zones towards the downstream end substantially of the same increment before the periodic displacement of the points of introduction and of withdrawal, characterized in that the process includes a sub-sequence without injection of the charge.

    PROCEDE ET DISPOSITIF DE SEPARATION AVEC DES ZONES CHROMATOGRAPHIQUES A LONGUEUR VARIABLE
    6.
    发明公开
    PROCEDE ET DISPOSITIF DE SEPARATION AVEC DES ZONES CHROMATOGRAPHIQUES A LONGUEUR VARIABLE 有权
    可变长度的色谱区分离工艺

    公开(公告)号：EP1128881A1

    公开(公告)日：2001-09-05

    申请号：EP99950884.9

    申请日：1999-10-29

    申请人： INSTITUT FRANCAIS DU PETROLE ,  Novasep

    发明人： BAILLY, Michel ,  ADAM, Philippe ,  LUDEMANN-HOMBOURGER, Olivier ,  NICOUD, Roger, Marc

    IPC分类号： B01D15/02

    CPC分类号： B01D15/1828 ,  B01D2215/023

    摘要： The invention concerns a method for separating at least a constituent of a mixture in a set of looping chromatographic columns, the loop comprising at least a point for injecting a load, a point for drawing off the raffinate, a point for injecting an eluting agent and a point for drawing of the extract. The method consists in: determining between an injection point and a drawing off point or vice-versa a chromatographic zone and at the end of a specific time interval, the whole set of injection points and drawing off points are offset by the same number of columns or column sections and advantageously from one column or one column section in a specific direction defined with respect to that of the flow of the main fluid circulating through the loop. During said time interval, the offsetting of the different injection and drawing off points of at least one column or column section is carried out at different times such that the length of the zones defined by the different points varies. The invention is useful in particular for separating stereoisomers for pharmaceutical purposes.

    PROCEDE DE SEPARATION SEQUENCE MULTICOLONNES
    7.
    发明授权
    PROCEDE DE SEPARATION SEQUENCE MULTICOLONNES 有权
    方法的顺序多柱分离的

    公开(公告)号：EP2040811B1

    公开(公告)日：2011-08-10

    申请号：EP07788903.8

    申请日：2007-06-18

    申请人： Groupe Novasep

    发明人： THEOLEYRE, Marc-André ,  BAUDOUIN, Stanislas ,  MERRIEN, Annick ,  VALERY, Eric ,  LUDEMANN-HOMBOURGER, Olivier ,  DAVID, Laurent ,  HOLZER, Margit

    IPC分类号： B01D15/18

    CPC分类号： B01D15/1871 ,  B01D15/1828 ,  B01D15/361 ,  B01D15/3804

    摘要： The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow means being placed between adjacent zones and between the last zone and the first zone, this process comprising several sequences, each sequence comprising at least one step chosen from an absorption step, a rinsing step and a desorption step, carried out either simultaneously or not, each following sequence is carried out by the displacement of the fronts in the zones towards the downstream end substantially of the same increment before the periodic displacement of the points of introduction and of withdrawal, characterized in that the process includes a sub-sequence without injection of the charge.

    PROCEDE ET DISPOSITIF DE SEPARATION DE FRACTIONS D'UN MELANGE
    9.
    发明公开
    PROCEDE ET DISPOSITIF DE SEPARATION DE FRACTIONS D'UN MELANGE 有权
    方法和装置分离的混合物馏分的

    公开(公告)号：EP1912716A2

    公开(公告)日：2008-04-23

    申请号：EP06794211.0

    申请日：2006-07-25

    申请人： Novasep

    发明人： VALERY, Eric ,  LUDEMANN-HOMBOURGER, Olivier

    IPC分类号： B01D15/18

    CPC分类号： B01D15/18 ,  B01D15/1857 ,  B01D15/1864 ,  B01D15/1871 ,  G01N30/461

    摘要： The invention concerns a method for separating fractions of a mixture to be separated, in a device (1) comprising: several chromatography columns (21, 22, 23, ) mounted in series; an open separation loop comprising in input a point for injecting (6) eluent in one of the columns and in output a point for drawing (8) a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (4); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points (6, 8) of the separation loop (4). The invention also concerns a device for separating fractions of a mixture to be separated.