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公开(公告)号：EP1778282A1
公开(公告)日：2007-05-02
申请号：EP05774364.3
申请日：2005-08-17
申请人： Institut Gustave Roussy , Centre National de la Recherche Scientifique , Université de Paris-Sud XI
CPC分类号： A61K39/21 , A61K38/162 , A61K2300/00 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/15022 , C12N2740/16322 , G01N2333/163
摘要： The present invention relates to the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of said protein.
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2.发明授权POLYPEPTIDE SEQUENCE INVOLVED IN THE MODULATION OF THE IMMUNOSUPPRESIVE EFFECT OF VIRAL PROTEINS 有权多肽序列与病毒蛋白的调制是否涉及IMMUNSUPPPRESSIVEN EFFECT
公开(公告)号：EP1732585B1
公开(公告)日：2010-06-30
申请号：EP05716455.0
申请日：2005-03-30
申请人： Institut Gustave Roussy , Centre National de la Recherche Scientifique , Université de Paris-Sud XI
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公开(公告)号：EP1778282B1
公开(公告)日：2016-03-30
申请号：EP05774364.3
申请日：2005-08-17
申请人： Institut Gustave Roussy , Centre National de la Recherche Scientifique , Université de Paris-Sud XI
IPC分类号： C07K14/005 , C07K14/16 , A61K39/21 , A61K38/16
CPC分类号： A61K39/21 , A61K38/162 , A61K2300/00 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/15022 , C12N2740/16322 , G01N2333/163
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4.发明公开POLYPEPTIDE SEQUENCE INVOLVED IN THE MODULATION OF THE IMMUNOSUPPRESIVE EFFECT OF VIRAL PROTEINS 有权多肽序列与病毒蛋白的调制是否涉及IMMUNSUPPPRESSIVEN EFFECT
公开(公告)号：EP1732585A1
公开(公告)日：2006-12-20
申请号：EP05716455.0
申请日：2005-03-30
申请人： Institut Gustave Roussy , Centre National de la Recherche Scientifique , Université de Paris-Sud XI
IPC分类号： A61K38/08 , C07K7/06 , C07K7/08 , A61K39/00 , A61K38/10 , C12N5/00 , C12N15/63 , C12N15/86 , C12N7/00 , C12N7/04
摘要： The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of said viral protein or fragment, said polypeptide comprising the minimum following consensus amino acid sequence: X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on said immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
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5.发明公开ENDOGENOUS RETROVIRUS AND PROTEINS ENCODED BY ENV AS A TARGET FOR CANCER TREATMENT 有权内源性逆转录和蛋白质编码BY env基因作为靶用于癌症治疗
公开(公告)号：EP1871391A2
公开(公告)日：2008-01-02
申请号：EP06727501.6
申请日：2006-03-30
发明人： MANGENEY, Marianne , RENARD, Martial , HEIDMANN, Therry , POTHLICHET, Julien , DEWANNIEUX, Marie
IPC分类号： A61K31/713 , A61K39/21
CPC分类号： A61K38/162 , C07K14/005 , C12N7/00 , C12N2740/10021 , C12N2740/10022
摘要： The present invention is directed to a method for the prevention and/or the treatment of cancer in a mammal, wherein the cancerous cells express at least one protein of endogenous retrovirus, particularly immunosuppressive protein such as env gene encoded protein from HERV-K, particularly the Np9 protein, said method comprising inhibiting the expression and/or the activity of said endogenous retrovirus and/or said env gene encoded immunosuppressive protein. The invention also relates to pharmaceutical compositions comprising nucleic acid capable of inhibiting said expression, ligand such as antibodies capable of inhibiting the activity of said env gene encoded protein, or immunogen or vaccinal composition capable of inducing an immune response, cellular or humoral response directed against said env gene encoded protein. The invention is further directed to the use of such env gene encoded protein, mutated or not, for the manufacture of a medicament or a vaccine composition intended for the prevention or the treatment of cancers.
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公开(公告)号：EP1259809B1
公开(公告)日：2006-12-13
申请号：EP01911813.2
申请日：2001-03-01
IPC分类号： G01N33/53 , G01N33/542
CPC分类号： G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/566
摘要： The invention concerns biosensors, the method for obtaining them and their uses in particular for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or a hapten, in a heterogeneous population. Said biosensors consist of (i) at least a protein-type receptor fragment, capable of binding with a suitable ligand via an active site and in which fragment, at least one of its amino acid residues, located in the proximity of said active site is naturally present in the form of a Cys residue or is substituted in Cys residue, and (ii) a fluorophore coupled with said Cys residue(s).
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