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11 条记录 (耗时 0.025 秒)

    TREATMENT OF MONOGENIC DISEASES WITH AN ANTI-CD45RC ANTIBODY
    7.
    发明公开
    TREATMENT OF MONOGENIC DISEASES WITH AN ANTI-CD45RC ANTIBODY 审中-公开

    公开(公告)号：EP3498293A1

    公开(公告)日：2019-06-19

    申请号：EP17306783.6

    申请日：2017-12-15

    申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  Universite de Nantes ,  Chu Nantes

    发明人： GUILLONNEAU, Carole ,  ANEGON, Ignacio

    IPC分类号： A61K39/395 ,  C07K16/28

    摘要： The present invention relates to an anti-CD45RC antibody for use in the treatment of monogenic diseases wherein genes involved in said monogenic diseases are:
    - genes which are not associated with immune function but whose deficiency is associated with inflammation and/or immune reactions, such as genes deficient in the following diseases: Duchenne muscular dystrophy (DMD), cystic fibrosis, lysosomal diseases and alpha1-anti-trypsin deficiency; or
    - genes involved in the immune system and whose deficiency generates inflammation and/or autoimmune reactions, such as genes deficient in the following diseases: T-cell primary immunodeficiencies such as IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome), APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy), B cell primary immunodeficiencies, Muckle-Wells syndrome, Mixed autoinflammatory and autoimmune syndrome, NLRP12-associated hereditary periodic fever syndrome, and Tumor necrosis factor receptor 1 associated periodic syndrome.
    The present invention is also directed to a composition and a kit comprising said anti-CD45RC antibody and an immunosuppressive and/or anti-inflammatory drug.

    AN ISOLATED INTERLEUKIN-34 POLYPEPTIDE FOR USE IN PREVENTING TRANSPLANT REJECTION AND TREATING AUTOIMMUNE DISEASES
    10.
    发明公开
    AN ISOLATED INTERLEUKIN-34 POLYPEPTIDE FOR USE IN PREVENTING TRANSPLANT REJECTION AND TREATING AUTOIMMUNE DISEASES 审中-公开
    ISOLATED白细胞介素34多肽FOR USE IN THE防治移植自身免疫性疾病的

    公开(公告)号：EP3169350A1

    公开(公告)日：2017-05-24

    申请号：EP15738908.1

    申请日：2015-07-17

    申请人： INSERM - Institut National de la Santé et de la Recherche Médicale ,  Universite de Nantes

    发明人： GUILLONNEAU, Carole ,  ANEGON, Ignacio ,  BEZIE, Séverine

    IPC分类号： A61K38/20 ,  A61P37/06

    CPC分类号： A61K38/20 ,  A61K31/436 ,  A61K45/06 ,  G01N33/564 ,  G01N33/6893 ,  G01N2333/54 ,  G01N2800/245 ,  G01N2800/50 ,  A61K2300/00

    摘要： The invention relates to an isolated interleukin-34 (IL-34) polypeptide for use in preventing or treating graft rejection, autoimmune disease, unwanted immune response against therapeutic proteins and allergy. The invention also provides an in vitro method for determining whether a patient is at risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies, comprising a step of determining the expression level of IL-34 in a biological sample obtained from said patient, wherein the presence of IL-34 is indicative of a reduced risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies.

    摘要翻译： 本发明涉及在分离的白细胞介素34（IL-34），用于预防或治疗移植物排斥，自身免疫性疾病，抗治疗性蛋白质和过敏不希望的免疫应答的使用多肽。 因此本发明提供了用于确定性采矿体外方法无论患者是在移植排斥，自身免疫性疾病，针对治疗性蛋白质或过敏不想要的免疫反应的风险，从获得的生物样品中包含确定性采矿的步骤IL-34的表达水平 所述患者，worin IL-34的存在指示移植排斥反应，自身免疫性疾病，针对治疗性蛋白质或过敏不想要的免疫应答的风险降低的。