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1.发明公开GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 审中-公开糖复合物及其作为候选疫苗预防感染福氏痢疾杆菌
公开(公告)号：EP2911698A1
公开(公告)日：2015-09-02
申请号：EP13783923.9
申请日：2013-10-29
申请人： Institut Pasteur , Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale , Université Paris Descartes
发明人： MULARD, Laurence , CHASSAGNE, Pierre , SANSONETTI, Philippe , PHALIPON, Armelle , TRAINCARD, François , NATO, Farida
IPC分类号： A61K47/48
CPC分类号： A61K47/4833 , A61K9/1271 , A61K38/164 , A61K47/48092 , A61K47/549 , A61K47/646 , C07K17/10 , C07K2317/76
摘要： The present invention relates to a conjugate comprising an oligo- or polysaccharide selected from the group consisting of: (X)
x -{BCDA}
n -(Y)
y (X)
x -{CDAB}
n -(Y)
y (X)
x -{DABC}
n -(Y)
y (X)
x -{ABCD}n-(Y)
y wherein A, B, C, D, X and Y, x, y and n are as defined in claim 1, said oligo- or polysaccharide being bound to a carrier.-
2.发明授权
公开(公告)号：EP2164521B1
公开(公告)日：2018-09-12
申请号：EP08805583.5
申请日：2008-05-16
发明人： MULARD, Laurence , BOUTET, Julien , GUERREIRO, Catherine , NATO, Farida , SANSONETTI, Philippe , PHALIPON, Armelle
CPC分类号： C07K16/1228 , A61K47/646 , C07H1/00 , C07H3/04 , C07H3/06 , C07H5/04
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3.发明公开GLYCOCONJUGUES ET LEUR UTILISATION COMME VACCIN CONTRE SHIGELLA FLEXNERI DE SEROTYPE 3A ET X 有权GLYCOKONJUGATE UND IHRE VERWENDUNG ALS IMPFSTOFF GEGEN DIE SHIGELLA FLEXNERI -SEROTYPEN 3A UND X
公开(公告)号：EP2164521A2
公开(公告)日：2010-03-24
申请号：EP08805583.5
申请日：2008-05-16
发明人： MULARD, Laurence , BOUTET, Julien , GUERREIRO, Catherine , NATO, Farida , SANSONETTI, Philippe , PHALIPON, Armelle
CPC分类号： C07K16/1228 , A61K47/646 , C07H1/00 , C07H3/04 , C07H3/06 , C07H5/04
摘要： The present invention relates to compounds derived from sugars which reproduce the epitopes of
Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a
Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.摘要翻译： 本发明涉及衍生自复制福氏志贺氏菌志贺氏菌血清型3a和X的表位的糖的化合物及其用于制备疫苗组合物的用途。 更具体地，本发明的主题涉及包含下文所述的寡糖或多糖的新型糖缀合化合物，涉及将这些寡糖或多糖和糖缀合物合成的方法，这些寡糖或多糖的衍生物用于含有该寡糖或多糖的组合物，还涉及 使用糖缀合物进行疫苗接种。 最后，本发明涉及使用一种或多种寡糖或多糖或其结合物来诊断志贺氏杆菌感染的方法。
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4.发明公开GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权糖复合物及其作为候选疫苗抗感染与志贺菌
公开(公告)号：EP1642132A2
公开(公告)日：2006-04-05
申请号：EP04744281.9
申请日：2004-07-02
申请人： INSTITUT PASTEUR , INSERM (Institut National de la Santé et de la Recherche Medicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： PHALIPON, Armelle , NATO, Farida , MULARD, Laurence , SANSONETTI, Philippe , GRANDJEAN, Cyrille , BALEUX, Francoise , BELOT, Frédéric
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B(E)CD} €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{(E)CDAB}n €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB(E)CD}n Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.
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5.发明授权GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权糖复合物及其作为候选疫苗抗感染与志贺菌
公开(公告)号：EP1642132B1
公开(公告)日：2011-06-22
申请号：EP04744281.9
申请日：2004-07-02
申请人： INSTITUT PASTEUR , INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： PHALIPON, Armelle , NATO, Farida , MULARD, Laurence , SANSONETTI, Philippe , GRANDJEAN, Cyrille , BALEUX, Francoise , BELOT, Frédéric
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B(E)CD} €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{(E)CDAB}n €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB(E)CD}n Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.
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公开(公告)号：EP1926495A2
公开(公告)日：2008-06-04
申请号：EP06793556.9
申请日：2006-09-15
CPC分类号： A61K38/164 , A61K38/45 , A61K39/0283 , A61K2039/521 , C07K14/4702 , C07K14/4703 , C07K14/4747 , C07K14/5421 , C07K14/5434 , C12N9/1205 , C12N9/16 , Y02A50/476
摘要： The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
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公开(公告)号：EP4247828A1
公开(公告)日：2023-09-27
申请号：EP21810384.4
申请日：2021-11-22
申请人： Institut Pasteur
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