公开(公告)号：EP3365453A2

公开(公告)日：2018-08-29

申请号：EP16805495.5

申请日：2016-10-20

申请人： Juno Therapeutics GmbH

发明人： TAREEN, Semih, U. ,  BASHOUR, Keenan

IPC分类号： C12N15/86

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/625 ,  C12N5/0634 ,  C12N2500/32 ,  C12N2501/515 ,  C12N2740/10043 ,  C12N2740/13043

摘要： Provided herein are methods for transducing a plurality of cells in a composition of cells, such as a population of lymphocytes, containing viral particles. In some aspects, provided methods and reagents for the transduction of cell populations involve binding of agents to a molecule on the surface of the cells. In some cases, the reagents are multimerization reagents and the one or more agents are multimerized by reversibly binding to the reagent. In some aspects, the multimerized agent can provide for transduction and/or expansion or proliferation or other stimulation of a population of cells, and then such agents can be removed by disruption of the reversible bond. Also provided are compositions, apparatus and methods of use thereof.

公开(公告)号：EP3151858A4

公开(公告)日：2018-01-17

申请号：EP15802830

申请日：2015-06-04

申请人： UNIV ARKANSAS ,  TEXAS A & M UNIV SYS

发明人： BERGHMAN LUC ,  CHEN CHANG-HSIN ,  CHOU WEN-KO ,  VUONG CHRISTINE ,  WAGHELA SURYAKANT ,  MWANGI WAITHAKA ,  HARGIS BILLY ,  ABI-GHANEM DAAD ,  BIELKE LISA

IPC分类号： A61K39/395

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0056 ,  A61K9/08 ,  A61K9/10 ,  A61K39/145 ,  A61K47/36 ,  A61K47/6881 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/575 ,  A61K2039/6056 ,  A61K2039/6087 ,  A61K2039/625 ,  C07K16/1018 ,  C07K16/1282 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/6878

摘要： Adjuvant compositions, vaccines, constructs for preparing the adjuvant compositions and vaccines and methods of using the adjuvant compositions and vaccines to enhance immune responses in subjects are provided herein. In particular, a rapid antibody response to the vaccine including both IgG (in the circulation) and sIgA (mucosal secretory IgA) is elicited. The adjuvants and vaccines may be used for sub-cutaneous or mucosal administration enabling low cost, effective vaccination of subjects. A method of epitope mapping to rapidly identify antigenic epitopes is also provided.

公开(公告)号：EP2706991A4

公开(公告)日：2015-05-06

申请号：EP12781636

申请日：2012-05-11

申请人： CHILDRENS MEDICAL CENTER

发明人： MALLEY RICHARD ,  LU YINGJIE ,  ZHANG FAN

IPC分类号： A61K31/00 ,  A61K38/00 ,  A61K39/02 ,  A61K39/39 ,  A61P37/02 ,  A61P37/04

CPC分类号： C07K14/31 ,  A61K39/092 ,  A61K39/385 ,  A61K47/543 ,  A61K47/557 ,  A61K47/61 ,  A61K2039/55505 ,  A61K2039/6031 ,  A61K2039/6093 ,  A61K2039/625 ,  A61K2039/627 ,  A61K2039/645 ,  C07K2319/00 ,  C07K2319/20

摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.

公开(公告)号：EP1934335A2

公开(公告)日：2008-06-25

申请号：EP06836129.4

申请日：2006-09-08

申请人： Large Scale Biology Corporation

发明人： LINDBO, John, A. ,  SMITH, Mark, L. ,  PALMER, Kenneth, E.

IPC分类号： C12N7/01

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/6075 ,  A61K2039/625 ,  C07K2319/00 ,  C07K2319/22 ,  C07K2319/60 ,  C12N7/00 ,  C12N15/8203 ,  C12N15/8257 ,  C12N15/8258 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2770/00022

摘要： Compositions and methods to utilize coat proteins of tobacco mosaic virus (TMV) as a scaffold with commonly available linker chemistries and surface antigens to enhance immune responses when used as a vaccination; randomized library to introduce a reactive lysine or cysteine residue externally located at the amino-terminus of the coat protein. TMV coat protein modification allows a controlled stoichiometric biotinylation of the Introduced lysine or cysteine residues further allowing the attachment of antigens using streptavidin as a linker to the biotinylated coat protein. A TMV-protein complex vaccine prepared utilizing this invention results in enhanced immunogenicity and a detectable humoral immune response after only a single immunization in mice.

公开(公告)号：EP0793506B1

公开(公告)日：2002-04-17

申请号：EP94930447.1

申请日：1994-09-16

申请人： ConjuChem, Inc.

发明人： POULETTY, Philippe ,  POULETTY, Christine

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  A61K47/48 ,  A61K39/385

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K39/385 ,  A61K47/6839 ,  A61K47/6849 ,  A61K47/6898 ,  A61K47/6901 ,  A61K2039/505 ,  A61K2039/6056 ,  A61K2039/625 ,  C07K14/005 ,  C07K14/70514 ,  C07K16/08 ,  C07K16/16 ,  C07K16/34 ,  C07K16/44 ,  C12N2740/16122

摘要： Novel bifunctional reagents useful in providing extended in vivo lifetimes of physiologically active agents are provided. The reagents comprise conjugates of a first binding member specific for a target in a mammalian host, such as a toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumourous cell, antigen presenting cell, or the like, joined to a second binding member specific for along-lived blood component, including cells, such as an erythrocyte, platelet or endothelial cell, and plasma proteins. These conjugates find use by extending the lifetime and availability of the target binding member for coupling the target and the blood component and thereby reducing the concentration free target, modulating the volume of distribution of the target, targeting the target to sites of enhanced immune response, facilitating target clearance from the bloodstream, or extending the stimulation of an immunogen.

公开(公告)号：EP1132097A3

公开(公告)日：2002-02-06

申请号：EP01107561.1

申请日：1994-09-16

申请人： ConjuChem, Inc.

发明人： Pouletty, Philippe ,  Pouletty, Christine

IPC分类号： A61K47/48

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K39/385 ,  A61K47/6839 ,  A61K47/6849 ,  A61K47/6898 ,  A61K47/6901 ,  A61K2039/505 ,  A61K2039/6056 ,  A61K2039/625 ,  C07K14/005 ,  C07K14/70514 ,  C07K16/08 ,  C07K16/16 ,  C07K16/34 ,  C07K16/44 ,  C12N2740/16122

摘要： Novel bifunctional reagents useful in providing extended in vivo lifetimes of physiologically active agents are provided. The reagents comprise conjugates of a first binding member specific for a target in a mammalian host, such as a toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumourous cell, antigen presenting cell, or the like, joined to a second binding member specific for a longlived blood component, including cells, such as an erythrocyte, platelet or endothelial cell, and plasma proteins. These conjugates find use by extending the lifetime and availability of the target binding member for coupling the target and the blood component and thereby reducing the concentration free target, modulating the volume of distribution of the target, targeting the target to sites of enhanced immune response, facilitating target clearance from the bloodstream, or extending the stimulation of an immunogen.

公开(公告)号：EP1132097A8

公开(公告)日：2001-11-28

申请号：EP01107561

申请日：1994-09-16

申请人： CONJUCHEM INC

发明人： POULETTY PHILIPPE ,  POULETTY CHRISTINE

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K39/385 ,  A61K39/395 ,  A61K47/48 ,  C07K14/16 ,  C07K14/73 ,  C07K16/08 ,  C07K16/16 ,  C07K16/28 ,  C07K16/34 ,  C07K16/44 ,  C07K16/46

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K39/385 ,  A61K47/6839 ,  A61K47/6849 ,  A61K47/6898 ,  A61K47/6901 ,  A61K2039/505 ,  A61K2039/6056 ,  A61K2039/625 ,  C07K14/005 ,  C07K14/70514 ,  C07K16/08 ,  C07K16/16 ,  C07K16/34 ,  C07K16/44 ,  C12N2740/16122

摘要： Novel bifunctional reagents useful in providing extended
in vivo lifetimes of physiologically active agents are provided. The reagents comprise conjugates of a first binding member specific for a target in a mammalian host, such as a toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumourous cell, antigen presenting cell, or the like, joined to a second binding member specific for a longlived blood component, including cells, such as an erythrocyte, platelet or endothelial cell, and plasma proteins. These conjugates find use by extending the lifetime and availability of the target binding member for coupling the target and the blood component and thereby reducing the concentration free target, modulating the volume of distribution of the target, targeting the target to sites of enhanced immune response, facilitating target clearance from the bloodstream, or extending the stimulation of an immunogen.

公开(公告)号：EP0793506A1

公开(公告)日：1997-09-10

申请号：EP94930447.0

申请日：1994-09-16

申请人： Redcell, Inc.

发明人： POULETTY, Philippe ,  POULETTY, Christine

IPC分类号： A61K38 ,  A61K39 ,  A61K47 ,  C07K14 ,  C07K16

CPC分类号： B82Y5/00 ,  A61K38/00 ,  A61K39/385 ,  A61K47/6839 ,  A61K47/6849 ,  A61K47/6898 ,  A61K47/6901 ,  A61K2039/505 ,  A61K2039/6056 ,  A61K2039/625 ,  C07K14/005 ,  C07K14/70514 ,  C07K16/08 ,  C07K16/16 ,  C07K16/34 ,  C07K16/44 ,  C12N2740/16122

摘要： Novel bifunctional reagents useful in providing extended in vivo lifetimes of physiologically active agents are provided. The reagents comprise conjugates of a first binding member specific for a target in a mammalian host, such as a toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumourous cell, antigen presenting cell, or the like, joined to a second binding member specific for along-lived blood component, including cells, such as an erythrocyte, platelet or endothelial cell, and plasma proteins. These conjugates find use by extending the lifetime and availability of the target binding member for coupling the target and the blood component and thereby reducing the concentration free target, modulating the volume of distribution of the target, targeting the target to sites of enhanced immune response, facilitating target clearance from the bloodstream, or extending the stimulation of an immunogen.

公开(公告)号：EP2970907A4

公开(公告)日：2017-04-19

申请号：EP14776027

申请日：2014-03-13

申请人： UNIV JOHNS HOPKINS

发明人： SCHNECK JONATHAN ,  OELKE MATHIAS ,  PERICA KARLO

IPC分类号： A61K39/39 ,  A61K35/12 ,  C12N5/078

CPC分类号： A61K47/48923 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/39 ,  A61K39/44 ,  A61K47/6849 ,  A61K47/6939 ,  A61K2039/5158 ,  A61K2039/55555 ,  A61K2039/572 ,  A61K2039/60 ,  A61K2039/605 ,  A61K2039/6087 ,  A61K2039/625 ,  A61K2039/64 ,  C12N5/0635 ,  C12N5/0636 ,  C12N2501/50 ,  C12N2501/51 ,  C12N2529/00 ,  C12N2533/10 ,  C12N2533/70

摘要： This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.

摘要翻译： 本公开提供纳米级人造抗原呈递细胞（aAPC），其向淋巴细胞（包括细胞毒性淋巴细胞）递送刺激信号，用作免疫治疗的有力工具。

公开(公告)号：EP1793863B1

公开(公告)日：2017-04-12

申请号：EP05788525.3

申请日：2005-09-30

申请人： Midatech Ltd.

发明人： HIMMLER, Gottfried ,  MUDDE, G., C. ,  KIRCHEIS, Ralf ,  RADEMACHER, T. Midatech Limited ,  PENADES ULLATE, Soledad ,  MARTIN LOMAS, Manuel ,  DE PAZ CARRERA, Jose Luis ,  OJEDA MARTINEZ DE CASTILLA, Rafael ,  BARRIENTES, Africa Garcia

IPC分类号： A61K47/69

CPC分类号： B82Y5/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K47/646 ,  A61K47/6923 ,  A61K47/6929 ,  A61K2039/55555 ,  A61K2039/6037 ,  A61K2039/625 ,  A61K2039/645 ,  Y02A50/412

摘要： Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.