公开(公告)号：EP3669875A1

公开(公告)日：2020-06-24

申请号：EP19843169.4

申请日：2019-06-19

申请人： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

发明人： CEN, Shan ,  LI, Quanjie ,  YI, Dongrong ,  SHI, Yi ,  WANG, Han ,  ZHOU, Jinming

IPC分类号： A61K31/472 ,  A61P31/14

摘要： The present invention provides use of berbamine dihydrochloride in preparation of an Ebola virus inhibitor. In the present invention, the primed glycoprotein of the Ebola virus (EBOV-GPcl) is taken as a target site, and an antiviral active compound with the capability of binding to the EBOV-GPcl, i.e., berbamine dihydrochloride, is obtained through structure-based virtual screening. Berbamine dihydrochloride can specifically inhibit the entry of an Ebola recombinant virus by binding to the target protein EBOV-GPcl, thereby achieving the effect of anti-Ebola virus infection. The half-maximum effect concentration (EC50) of berbamine dihydrochloride against EBOV is 0.49 µM, which indicates that berbamine dihydrochloride has a strong inhibition effect on EBOV.

公开(公告)号：EP2351731B1

公开(公告)日：2016-02-10

申请号：EP09817185.3

申请日：2009-09-28

申请人： Institute Of Medicinal Biotechnology, Chinese Academy of Medical Sciences

发明人： JIANG, Jiandong ,  YU, Liyan ,  CEN, Shan ,  LI, Zhuorong ,  LI, Yanping ,  XU, Jian

IPC分类号： C07C237/44 ,  C07C309/76 ,  C07C311/46 ,  A61K31/167 ,  A61K31/16 ,  A61P31/12 ,  C07C327/28 ,  C07D207/36 ,  C07D213/75 ,  C07D239/47 ,  C07D239/52 ,  C07D307/66 ,  C07C233/43 ,  C07C233/54 ,  C07C255/57 ,  C07C229/60

CPC分类号： C07C327/28 ,  C07C229/60 ,  C07C233/25 ,  C07C233/33 ,  C07C233/43 ,  C07C233/54 ,  C07C237/42 ,  C07C237/44 ,  C07C255/57 ,  C07C309/76 ,  C07C311/08 ,  C07C311/29 ,  C07C311/44 ,  C07C311/46 ,  C07D207/36 ,  C07D213/75 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D307/66

公开(公告)号：EP2351731A1

公开(公告)日：2011-08-03

申请号：EP09817185.3

申请日：2009-09-28

申请人： Institute Of Medicinal Biotechnology, Chinese Academy of Medical Sciences

发明人： JIANG, Jiandong ,  YU, Liyan ,  CEN, Shan ,  LI, Zhuorong ,  LI, Yanping ,  XU, Jian

IPC分类号： C07C237/44 ,  C07C233/12 ,  C07C229/54 ,  C07C327/16 ,  C07C307/02 ,  C07C303/26 ,  C07D239/52 ,  A61K31/21 ,  A61K31/165 ,  A61K31/255 ,  A61P31/12

CPC分类号： C07C327/28 ,  C07C229/60 ,  C07C233/25 ,  C07C233/33 ,  C07C233/43 ,  C07C233/54 ,  C07C237/42 ,  C07C237/44 ,  C07C255/57 ,  C07C309/76 ,  C07C311/08 ,  C07C311/29 ,  C07C311/44 ,  C07C311/46 ,  C07D207/36 ,  C07D213/75 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D307/66

摘要： A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.

摘要翻译： 一组氨基取代的苯甲酰基衍生物，其制备及其用途。 以hA3G / Vif为靶点的抗病毒药物的筛选和研究证明，3-氨基苯甲酰基衍生物不仅具有hA3G / Vif的组合活性，而且具有抑制病毒复制的功能。 本发明提供了HIV耐药性问题可能的突破性进展，从而提供了具有更高效率的新型临床抗病毒药物。