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1.发明公开A METHOD OF EVALUATING THE THERAPEUTIC EFFICACY OF BACTERIOPHAGES 有权VERFAHREN ZUR BEWERTUNG DER THERAPEUTISCHEN WIRKSAMKEIT VON BAKTERIOPHAGEN
公开(公告)号：EP2872156A1
公开(公告)日：2015-05-20
申请号：EP13741984.2
申请日：2013-07-13
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk , Narodowy Instytut Leków , Szkola Glówna Gospodarstwa Wiejskiego W Warszawie , Wojskowy Instytut Higieny I Epidemiologii
发明人： LOBOCKA, Malgorzata , GLOWACKA, Aleksandra , DABROWSKI, Kamil , HEJNOWICZ, Monika S. , GOZDEK, Agnieszka , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej , EMPEL, Joanna , HRYNIEWICZ, Waleria , KWIATEK, Magdalena , PARASION, Sylwia , GRYKO, Romuald
IPC分类号： A61K35/76
CPC分类号： G01N33/5085 , A61K35/76 , G01N2333/4353 , Y02A50/475 , Y02A50/481
摘要： The subject of the present invention is a novel use of a nematode in the evaluation of the therapeutic efficacy of bacteriophage preparations used in, or capable of being used in the treatment of infections caused by pathogenic bacteria in humans or animals.
摘要翻译： 本发明的主题是线虫评估用于或能够用于治疗由人或动物中的病原菌引起的感染的噬菌体制剂的治疗功效的新用途。
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2.发明公开ENTEROCOCCUS FAECALIS STRAINS FOR THE PRODUCTION OF BACTERIOPHAGE PREPARATIONS 审中-公开Enterococcus FAECALIS菌株用于生产噬菌体制剂
公开(公告)号：EP3186361A1
公开(公告)日：2017-07-05
申请号：EP15778720.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
发明人： LOBOCKA, Malgorzata , GOZDEK, Agnieszka , IZAK, Dariusz , ZALEWSKA, Agnieszka , GAWOR, Jan , DABROWSKI, Kamil , GROMADKA, Robert , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej
CPC分类号： C12R1/46 , C12N7/00 , C12N2795/00051
摘要： Disclosed are Enterococcus faecalis strains for obtaining monoclonal preparations of lytic bacteriophages with high titer, particularly devoid of contamination with undesired bacteriophages, the strains guaranteeing the production of safe to use bacteriophage preparations, not being a source of dissemination of genes associated with bacterial virulence.
摘要翻译： 公开了粪肠球菌菌株用于获得具有高效价的溶解性噬菌体的单克隆制备物，特别是没有不希望的噬菌体污染，所述菌株保证产生安全使用的噬菌体制剂，而不是与细菌毒力相关的基因传播的来源。
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公开(公告)号：EP3186370B1
公开(公告)日：2020-01-01
申请号：EP15780935.1
申请日：2015-08-27
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
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公开(公告)号：EP3186362B1
公开(公告)日：2019-05-15
申请号：EP15797403.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Doswiadczalnej Polskiej Akademii
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公开(公告)号：EP3186361B1
公开(公告)日：2019-06-05
申请号：EP15778720.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
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公开(公告)号：EP2872156B1
公开(公告)日：2017-08-09
申请号：EP13741984.2
申请日：2013-07-13
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk , Narodowy Instytut Leków , Szkola Glówna Gospodarstwa Wiejskiego W Warszawie , Wojskowy Instytut Higieny I Epidemiologii
发明人： LOBOCKA, Malgorzata , GLOWACKA, Aleksandra , DABROWSKI, Kamil , HEJNOWICZ, Monika S. , GOZDEK, Agnieszka , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej , EMPEL, Joanna , HRYNIEWICZ, Waleria , KWIATEK, Magdalena , PARASION, Sylwia , GRYKO, Romuald
IPC分类号： A61K35/76
CPC分类号： G01N33/5085 , A61K35/76 , G01N2333/4353 , Y02A50/475 , Y02A50/481
摘要： The subject of the present invention is a novel use of a nematode in the evaluation of the therapeutic efficacy of bacteriophage preparations used in, or capable of being used in the treatment of infections caused by pathogenic bacteria in humans or animals.
摘要翻译： 本发明的主题是线虫在评价用于或能够用于治疗由人或动物中的致病细菌引起的感染的噬菌体制剂的治疗功效中的新用途。
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7.发明公开ENZYME WITH HIGH LYTIC ACTIVITY AGAINST ENTEROCOCCUS CELL AND A METHOD OF MODIFICATION OF THE GENE THEREOF, ENABLING OVERPRODUCTION OF ACTIVE ENZYME IN BACTERIAL CELLS 审中-公开具有高活性的酶对肠球菌细胞的修饰及其基因修饰方法，使活性酶在细菌中过量生成
公开(公告)号：EP3186370A1
公开(公告)日：2017-07-05
申请号：EP15780935.1
申请日：2015-08-27
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
发明人： LOBOCKA, Malgorzata , GOZDEK, Agnieszka , KOSAKOWSKI, Jaroslaw , RÓZYCKA, Aleksandra , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej
摘要： Disclosed is an enzyme with high lytic activity against Enterococcus cells and a method of modification of the gene thereof, enabling overproduction of active enzyme in bacterial cells.
摘要翻译： 公开了一种对肠球菌细胞具有高溶解活性的酶及其基因的修饰方法，其能够在细菌细胞中过量生产活性酶。
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8.发明授权
公开(公告)号：EP2344642B8
公开(公告)日：2013-08-21
申请号：EP09753232.9
申请日：2009-09-27
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/00021 , C12N2795/00032
摘要： Novel bacteriophage strains are disclosed and their use in the production of preparations for use in the treatment of bacterial infections, particularly with drug resistant strains of bacteria of the genus Enterococcus, particularly those belonging to the species Enterococcus faecalis.
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9.发明公开STAPHYLOCOCCUS AUREUS STRAINS FOR PRODUCTION OF MONOCLONAL PHAGE PREPARATIONS DEPRIVED OF CONTAMINATION WITH PLASMID DNA 审中-公开用于制备用质粒DNA污染的单克隆制备物的金黄色葡萄球菌菌株
公开(公告)号：EP3186362A1
公开(公告)日：2017-07-05
申请号：EP15797403.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Do Wiadczalnej Polskiej Akademii Nauk
发明人： LOBOCKA, Malgorzata , HEJNOWICZ, Monika , DABROWSKI, Kamil , IZAK, Dariusz , GOZDEK, Agnieszka , GLOWACKA, Aleksandra , GAWOR, Jan , KOSAKOWSKI, Jaroslaw , GROMADKA, Robert , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej
CPC分类号： C12R1/445 , C12N1/20 , C12N7/00 , C12N2795/00051
摘要： Disclosed are Staphylococcus aureus strains for obtaining monoclonal preparations of lytic bacteriophages with high titer, devoid of contamination with undesired bacteriophages and plasmid DNA, which guarantee the production of safe to use bacteriophage preparations, not being a source of dissemination of genes associated with bacterial virulence.
摘要翻译： 公开了金黄色葡萄球菌菌株用于获得高滴度的溶解性噬菌体的单克隆制备物，其不含不希望的噬菌体和质粒DNA的污染，其保证产生安全使用的噬菌体制剂，而不是与细菌毒力相关的基因传播的来源。
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