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1.发明公开AN RNA OLIGOMER, METHODS FOR REGULATING A MICRORNA PRODUCTION PROCESS AND RNA OLIGOMERS USED AS MICRORNA PRODUCTION PROCESS REGULATORS 审中-公开RNA低聚物的方法用于控制的微小RNA的生产工艺和作为使用RNA低聚物的microRNA调节器的方法
公开(公告)号：EP2817408A1
公开(公告)日：2014-12-31
申请号：EP13711481.5
申请日：2013-02-20
发明人： KURZYNSKA-KOKORNIAK, Anna , KORALEWSKA, Natalia , FIGLEROWICZ, Marek , TYCZEWSKA, Agata , TWARDOWSKI, Tomasz
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16
摘要： The present invention relates to an RNA oligomer, methods for regulating ' a miRNA production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligomers disrupting a pre-miRNA structure as miRNA production process regulators. Oligomer interactions with a miRNA precursor (pre-miRNA) change the precursor' s secondary and tertiary structure. In consequence, the pre-miRNA is not specifically recognised and cleaved by the Dicer ribonuclease, and the specific miRNA is not produced.
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2.发明授权METHOD TO INHIBIT RIBONUCLEASE DICER, RIBONUCLEASE DICER INHIBITOR, AND USE OF RNA APTAMERS AS RIBONUCLEASE DICER INHIBITORS 有权于抑制核糖核酸酶Dicer酶，核糖核酸酶Dicer酶抑制剂和RNA适体核糖核酸酶Dicer酶的使用方法抑制剂
公开(公告)号：EP2255002B1
公开(公告)日：2014-04-02
申请号：EP09709670.5
申请日：2009-02-09
IPC分类号： C12N15/11
CPC分类号： C12N15/115 , C12N2310/141 , C12N2310/16
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3.发明公开METHOD TO INHIBIT RIBONUCLEASE DICER, RIBONUCLEASE DICER INHIBITOR, AND USE OF RNA APTAMERS AS RIBONUCLEASE DICER INHIBITORS 有权于抑制核糖核酸酶Dicer酶，核糖核酸酶Dicer酶抑制剂和RNA适体核糖核酸酶Dicer酶的使用方法抑制剂
公开(公告)号：EP2255002A2
公开(公告)日：2010-12-01
申请号：EP09709670.5
申请日：2009-02-09
IPC分类号： C12N15/11
CPC分类号： C12N15/115 , C12N2310/141 , C12N2310/16
摘要： The subject of the present invention is a method to inhibit ribonuclease Dicer, ribonuclease Dicer inhibitor, and use of RNA aptamers to inhibit ribonuclease Dicer. More specifically, this solution relates to using RNA aptamers as ribonuclease Dicer inhibitors that acts upon the competition basis (aptamers as competence inhibitors), use of RNA aptamers as allosteric ribonuclease Dicer inhibitors, and use of RNA aptamers as selective inhibitors of emergence of the selected miRNAs.
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