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1.发明公开IMMUNOGENIC COMPOSITION COMPRISING PANTON-VALENTINE LEUKOCIDIN (PVL) DERIVED POLYPEPTIDES 审中-公开从潘顿-Valentine杀白细胞素（PVL）免疫原性组合物的多肽
公开(公告)号：EP2785368A1
公开(公告)日：2014-10-08
申请号：EP12854165.3
申请日：2012-11-30
发明人： AMAN, Mohammad Javad , ADHIKARI, Rajan Prasad , KARAUZUM, Hatice , SARWAR, Jawad , SHULENIN, Sergey , VENKATARAMANI, Sathya , WARFIELD, Kelly Lyn , NGUYEN, Tam Luong
CPC分类号： C12N9/10 , A61K39/085 , A61K2039/505 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/31 , C07K16/1271 , C07K16/40
摘要： The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure provides methods of inducing an immune response against a panton-valentine leukocidin (PVL)-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.
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2.发明授权
公开(公告)号：EP2785368B1
公开(公告)日：2019-03-13
申请号：EP12854165.3
申请日：2012-11-30
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3.发明授权
公开(公告)号：EP3010535B1
公开(公告)日：2019-08-14
申请号：EP14813512.2
申请日：2014-06-18
发明人： AMAN, Mohammad Javad , ADHIKARI, Rajan Prasad , SHULENIN, Sergey , HOLTSBERG, Frederick Wayne , KARAUZUM, Hatice
IPC分类号： A61K39/085
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公开(公告)号：EP2672989A1
公开(公告)日：2013-12-18
申请号：EP12744843.9
申请日：2012-02-06
发明人： AMAN, Mohammad Javad , ADHIKARI, Rajan Prasad , KARAUZUM, Hatice , WARFIELD, Kelly Lyn , NGUYEN, Tam Luong
CPC分类号： C07K14/31 , A61K38/00 , A61K39/085 , A61K39/39 , A61K2039/505 , A61K2039/55505 , A61K2039/55572 , C07K16/1271 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/24 , C07K2319/33 , C07K2319/40 , C07K2319/43 , C07K2319/60
摘要： The present invention provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present invention provides methods of inducing an immune response against an alpha-hemolysin-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.
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5.发明公开TARGETING IMMUNOLOGICAL FUNCTIONS TO THE SITE OF BACTERIAL INFECTIONS USING CELL WALL TARGETING DOMAINS OF BACTERIOLYSINS 审中-公开免疫组化免疫组化免疫印度尼西亚麻醉药联合麻醉药ZELLWANDTARGETINGDOMÄNENVON BACTERIOLYSINEN
公开(公告)号：EP3094348A1
公开(公告)日：2016-11-23
申请号：EP15736937.2
申请日：2015-01-14
IPC分类号： A61K39/02
CPC分类号： C07K16/1271 , A61K38/00 , C07K14/195 , C07K2317/24 , C07K2317/76 , C07K2319/00 , C07K2319/70 , C12N9/52 , C12Y304/24075
摘要： This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that consist of a bacteriocin cell wall targeting domain (CWT) and an immune function mediating component (IFMC). The CWT targets the fusion protein to the bacterial surface leading to accumulation at the site of infection. The IFMC mediates various immune functions such as toxin neutralization or recruitment of immune cells that can clear the bacteria.
摘要翻译： 本公开提供了通过由细菌素细胞壁靶向结构域（CWT）和免疫功能介导成分（IFMC）组成的多种融合蛋白来特异性靶向针对感染部位的各种免疫功能的综合方法。 CWT将融合蛋白靶向细菌表面，导致在感染部位积聚。 IFMC介导各种免疫功能，例如毒素中和或能够清除细菌的免疫细胞的募集。
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6.发明公开TOXOID PEPTIDES DERIVED FROM PHENOL SOLUBLE MODULIN, DELTA TOXIN, SUPERANTIGENS, AND FUSIONS THEREOF 审中-公开来自苯酚可溶性调节素，三角洲毒素，超级抗原及其融合的毒性肽
公开(公告)号：EP3010535A1
公开(公告)日：2016-04-27
申请号：EP14813512.2
申请日：2014-06-18
发明人： AMAN, Mohammad Javad , ADHIKARI, Rajan Prasad , SHULENIN, Sergey , HOLTSBERG, Frederick Wayne , KARAUZUM, Hatice
IPC分类号： A61K39/085
CPC分类号： C07K14/31 , A61K38/00 , A61K39/085 , A61K2039/55572 , A61K2039/70
摘要： The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure provides delta toxin and phenol-soluble modulin peptides as well as mutants, fragments, variants or derivatives thereof. The disclosure further provides multivalent oligopeptides, fusion proteins comprising two or more staphylococcal proteins, e.g., DT, PSM, alpha hemolysin, leukocidin, superantigen, or any fragments, variants, derivatives, or mutants thereof fused together as a single polypeptide in any order.
摘要翻译： 本公开提供用于预防和治疗金黄色葡萄球菌感染的免疫原性组合物。 具体而言，本公开内容提供了δ毒素和苯酚可溶调节素肽以及其突变体，片段，变体或衍生物。 本公开进一步提供了多价寡肽，包含两种或更多种葡萄球菌蛋白例如DT，PSM，α溶血素，白细胞杀伤素，超抗原或其以任何顺序作为单个多肽融合在一起的任何片段，变体，衍生物或突变体的融合蛋白。
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