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公开(公告)号：EP1924594A2
公开(公告)日：2008-05-28
申请号：EP06800088.4
申请日：2006-07-17
发明人： SEIWERT, Scott D. , BLATT, Lawrence M. , ANDREWS, Steven W. , MARTIN, Pierre , SCHUMACHER, Andreas , BARNETT, Bradley R. , EARY, C., Todd , KAUS, Robert , KERCHER, Timothy , LIU, Weidong , LYON, Michael , NICHOLS, Paul , WANG, Bin , SAMMAKIA, Tarek , KENNEDY, April , JIANG, Yutong
IPC分类号： C07K5/12 , A61K38/00 , A61P31/14 , C07D209/44 , C07C231/02 , C07C269/00 , C07D207/16
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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公开(公告)号：EP2160392A2
公开(公告)日：2010-03-10
申请号：EP08755035.6
申请日：2008-05-02
发明人： BLATT, Lawrence, M. , PAN, Lin , SEIWERT, Scott , ANDREWS, Steven, W. , MARTIN, Pierre , SCHUMACHER, Andreas , BEIGELMAN, Leonid , LIU, Jyanwei , CONDROSKI, Kevin , JIANG, Yutong , KAUS, Robert , KENNEDY, April , KERCHER, Timothy , LYON, Michael , WANG, Bin
IPC分类号： C07D487/04 , C08H1/00 , A61K31/407 , A61P31/12
CPC分类号： C07D487/04
摘要： The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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