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公开(公告)号：EP1924594A2
公开(公告)日：2008-05-28
申请号：EP06800088.4
申请日：2006-07-17
发明人： SEIWERT, Scott D. , BLATT, Lawrence M. , ANDREWS, Steven W. , MARTIN, Pierre , SCHUMACHER, Andreas , BARNETT, Bradley R. , EARY, C., Todd , KAUS, Robert , KERCHER, Timothy , LIU, Weidong , LYON, Michael , NICHOLS, Paul , WANG, Bin , SAMMAKIA, Tarek , KENNEDY, April , JIANG, Yutong
IPC分类号： C07K5/12 , A61K38/00 , A61P31/14 , C07D209/44 , C07C231/02 , C07C269/00 , C07D207/16
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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公开(公告)号：EP4306171A2
公开(公告)日：2024-01-17
申请号：EP23211278.9
申请日：2013-10-18
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-Christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide.
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公开(公告)号：EP2909182A1
公开(公告)日：2015-08-26
申请号：EP13847106.5
申请日：2013-10-18
申请人： Novartis AG , Array Biopharma, Inc.
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00
CPC分类号： A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
摘要： The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：EP4306171A3
公开(公告)日：2024-04-03
申请号：EP23211278.9
申请日：2013-10-18
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-Christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide.
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公开(公告)号：EP3702351A1
公开(公告)日：2020-09-02
申请号：EP19211405.6
申请日：2013-10-18
发明人： KRELL, Christoph, Max , MISUN, Marian , NIEDERER, Daniel, Andreas , PACHINGER, Werner, Heinz , WOLF, Marie-Christine , ZIMMERMANN, Daniel , LIU, Weidong , STENGEL, Peter, J. , NICHOLS, Paul
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, at least one sugar, and at least one cellulose-derivative excipient.
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