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公开(公告)号：EP2271663B1
公开(公告)日：2016-03-16
申请号：EP09738098.4
申请日：2009-04-27
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N2770/12021 , C12N2770/12022 , C12N2770/12051
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公开(公告)号：EP4210740A1
公开(公告)日：2023-07-19
申请号：EP21773074.6
申请日：2021-09-06
IPC分类号： A61K39/12 , A61K39/145 , A61P31/16 , A61P37/04 , C07K14/005 , C07K14/11
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3.发明授权
公开(公告)号：EP2629794B1
公开(公告)日：2017-06-07
申请号：EP11771123.4
申请日：2011-10-17
IPC分类号： A61K39/145 , C07K14/11 , C12N15/869
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , A61K2039/552 , C07K14/005 , C12N15/86 , C12N15/869 , C12N2710/16343 , C12N2760/16122 , C12N2760/16134 , C12N2830/60
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公开(公告)号：EP3185899B1
公开(公告)日：2017-10-18
申请号：EP15817860.8
申请日：2015-12-23
IPC分类号： A61K39/12 , A61K39/17 , A61K39/295 , C07K14/005 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/17 , A61K39/295 , A61K2039/5256 , A61K2039/54 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N2710/16343 , C12N2720/10022 , C12N2720/10034 , C12N2720/10071 , C12N2760/18134 , C12N2760/18171 , C12N2830/34 , C12N2830/50 , C12N2830/60
摘要： The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F—and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.
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公开(公告)号：EP3185899A1
公开(公告)日：2017-07-05
申请号：EP15817860.8
申请日：2015-12-23
IPC分类号： A61K39/12 , A61K39/17 , A61K39/295 , C07K14/005 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/17 , A61K39/295 , A61K2039/5256 , A61K2039/54 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N2710/16343 , C12N2720/10022 , C12N2720/10034 , C12N2720/10071 , C12N2760/18134 , C12N2760/18171 , C12N2830/34 , C12N2830/50 , C12N2830/60
摘要： The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F—and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.
摘要翻译： 本发明涉及新的和改进的HVT-载体ND-IBD疫苗，其包含含有来自IBDV的VP2基因和来自NDV的F基因的重组HVT到靶动物。 重组HVT可用于家禽疫苗，其表现出良好的病毒载体复制，NDV F-和IBDV VP2基因的有效表达，针对ND和IBD的改进的免疫保护，以及相对于现有技术构建体的改进的遗传稳定性。
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公开(公告)号：EP4215207A1
公开(公告)日：2023-07-26
申请号：EP22212994.2
申请日：2017-06-15
发明人： COOK, Stephanie , MORSEY, Mohamad , TARPEY, Ian , VERSTEGEN, Iwan , SONDERMEIJER, Paulus, Jacobus, Antonius , VERMEIJ, Paul
IPC分类号： A61K39/12 , A61K39/245 , C12N15/86
摘要： The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.
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公开(公告)号：EP3471766A1
公开(公告)日：2019-04-24
申请号：EP17734653.3
申请日：2017-06-15
发明人： COOK, Stephanie , MORSEY, Mohamad , TARPEY, Ian , VERSTEGEN, Iwan , SONDERMEIJER, Paulus, Jacobus, Antonius , VERMEIJ, Paul
IPC分类号： A61K39/12 , A61K39/245 , C12N15/86
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公开(公告)号：EP3727431A1
公开(公告)日：2020-10-28
申请号：EP18833414.8
申请日：2018-12-19
发明人： DE GROOF, Ad , VERSTEGEN, Iwan
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10.发明公开RECOMBINANT NONPATHOGENIC MDV VECTOR PROVIDING MULTIVALENT IMMUNITY 审中-公开重组MDV，非致病性载体把MULTI VALENTE抗扰度
公开(公告)号：EP2768529A1
公开(公告)日：2014-08-27
申请号：EP12778293.6
申请日：2012-10-19
CPC分类号： C12N15/86 , A61K39/12 , A61K39/17 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N2710/16343 , C12N2720/10034 , C12N2760/18134
摘要： The present invention relates to the field of veterinary vaccines, in particular to that of vector vaccines for poultry based on recombinant nonpathogenic Marek's disease virus (npMDV). The recombinant npMDV of the invention expresses stably and effectively two heterologous genes each originating from a different micro-organism: the fusion protein gene from Newcastle disease virus, and the viral protein 2 gene from infectious bursal disease virus. A vaccine based on this recombinant npMDV can be used to induce in poultry a protective immune response not only against Marek's disease, but also against Newcastle disease and Infectious bursal disease. The invention also relates to methods and uses involving the recombinant npMDV, expression cassette, infected host cells, and vaccines.
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