公开(公告)号：EP3334833A1

公开(公告)日：2018-06-20

申请号：EP16835663.2

申请日：2016-08-04

申请人： The Texas A&M University System

发明人： REDDY, Sanjay, M. ,  LUPIANI, Blanca, M.

IPC分类号： C12N15/869 ,  A61K39/255 ,  A61K39/17 ,  A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16371 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/10071

摘要： The present disclosure provides a recombinant viral vector comprising at least one transgene inserted into a Marek's disease viral genome for treatment of diseases in poultry. Also provided are immunogenic compositions comprising such recombinant viral vectors and methods for preventing or inhibiting Marek's disease in combination with at least a second disease in poultry.

公开(公告)号：EP2845904A1

公开(公告)日：2015-03-11

申请号：EP13183393.1

申请日：2013-09-06

申请人： Ceva Sante Animale

发明人： Esaki, Motoyuki ,  Saitoh, Shuji ,  Sato, Takanori

IPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K39/02 ,  A61K39/145 ,  C12N5/10

CPC分类号： A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2710/16371 ,  C12N2720/10034 ,  C12N2720/10051 ,  C12N2720/10071 ,  C12N2760/16034 ,  C12N2760/18134

摘要： The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses encoding polypeptide(s) of interest, and their use to express or deliver such polypeptides to animals, particularly poultry. The invention is particularly suited to vaccinate poultry against avian pathogens.

摘要翻译： 本发明涉及重组病毒及其用途。 更具体地，本发明涉及编码感兴趣多肽的新型重组马立克氏病病毒，以及它们用于将动物特别是家禽表达或递送这些多肽的用途。 本发明特别适用于针对禽类病原体接种家禽。

公开(公告)号：EP3041939A1

公开(公告)日：2016-07-13

申请号：EP14759200.0

申请日：2014-09-05

申请人： Ceva Sante Animale

发明人： ESAKI, Motoyuki ,  SAITOH, Shuji ,  SATO, Takanori

IPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K39/02 ,  A61K39/145 ,  C12N5/10

CPC分类号： A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2710/16371 ,  C12N2720/10034 ,  C12N2720/10051 ,  C12N2720/10071 ,  C12N2760/16034 ,  C12N2760/18134

摘要： The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses encoding polypeptide(s) of interest, and their use to express or deliver such polypeptides to animals, particularly poultry. The invention is particularly suited to vaccinate poultry against avian pathogens.

摘要翻译： 本发明涉及重组病毒及其用途。 更具体地，本发明涉及编码感兴趣多肽的新型重组马立克氏病病毒，以及它们用于将动物特别是家禽表达或递送这些多肽的用途。 本发明特别适用于针对禽类病原体接种家禽。

公开(公告)号：EP3328423A1

公开(公告)日：2018-06-06

申请号：EP16747758.7

申请日：2016-07-27

申请人： Bayer Animal Health GmbH

发明人： WEISS, Christian ,  SIMARD, Nathalie C. ,  KOESLING, Jan

IPC分类号： A61K39/12 ,  A61K39/39

CPC分类号： A61K39/12 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2720/10034 ,  C12N2720/10071

摘要： The present invention generally relates to methods of eliciting an immune response in an aquatic species subject. In particular, an immunomodulator composition is used to induce an immune response to enhance the subject's ability to fight pathogens.

公开(公告)号：EP3391903A1

公开(公告)日：2018-10-24

申请号：EP17167638.0

申请日：2017-04-21

申请人： The Pirbright Institute

发明人： SADIGH, Yashar ,  NAIR, Venugopal

IPC分类号： A61K39/17 ,  A61K39/255

CPC分类号： A61K39/255 ,  C12N2720/10034 ,  C12N2720/10071

摘要： The invention relates to a recombinant Gallid herpesvirus 3 vector encoding heterologous avian pathogen antigens comprising one or more heterologous polynucleotide(s) inserted into the intergenic loci UL3/UL4 and/or UL21/UL22. The invention further relates to vaccines comprising said recombinant Gallid herpesvirus 3 vector and optionally a further Marek's disease virus vector and to a use of the vaccine for protecting an avian species against one or more avian pathogens. Further methods for treating an avian species for protection against one or more diseases caused by avian pathogens and a method for producing the recombinant Gallid herpesvirus 3 vector encoding heterologous avian pathogen antigens is provided.

公开(公告)号：EP3185899B1

公开(公告)日：2017-10-18

申请号：EP15817860.8

申请日：2015-12-23

申请人： Intervet International B.V.

发明人： VERSTEGEN, Iwan ,  SONDERMEIJER, Paulus, Jacobus, Antonius ,  VERMEIJ, Paul

IPC分类号： A61K39/12 ,  A61K39/17 ,  A61K39/295 ,  C07K14/005 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K39/295 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N2710/16343 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134 ,  C12N2760/18171 ,  C12N2830/34 ,  C12N2830/50 ,  C12N2830/60

摘要： The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F—and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.

公开(公告)号：EP3185899A1

公开(公告)日：2017-07-05

申请号：EP15817860.8

申请日：2015-12-23

申请人： Intervet International B.V.

发明人： VERSTEGEN, Iwan ,  SONDERMEIJER, Paulus, Jacobus, Antonius ,  VERMEIJ, Paul

IPC分类号： A61K39/12 ,  A61K39/17 ,  A61K39/295 ,  C07K14/005 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K39/295 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N2710/16343 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134 ,  C12N2760/18171 ,  C12N2830/34 ,  C12N2830/50 ,  C12N2830/60

摘要： The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F—and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.

摘要翻译： 本发明涉及新的和改进的HVT-载体ND-IBD疫苗，其包含含有来自IBDV的VP2基因和来自NDV的F基因的重组HVT到靶动物。 重组HVT可用于家禽疫苗，其表现出良好的病毒载体复制，NDV F-和IBDV VP2基因的有效表达，针对ND和IBD的改进的免疫保护，以及相对于现有技术构建体的改进的遗传稳定性。

公开(公告)号：EP3050572A1

公开(公告)日：2016-08-03

申请号：EP15305102.4

申请日：2015-01-29

申请人： Ceva Sante Animale

发明人： Ishihara, Yukari ,  Esaki, Motoyuki ,  Saitoh, Shuji

IPC分类号： A61K39/255

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N2710/16311 ,  C12N2710/16321 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134

摘要： The present invention relates to recombinant MDV1 viruses and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.

摘要翻译： 本发明涉及重组MDV1病毒及其用途。 本发明特别适用于针对禽类病原体接种家禽。