公开(公告)号：EP0984000A4

公开(公告)日：2004-08-11

申请号：EP96931297

申请日：1996-09-24

申请人： JAPAN TOBACCO INC ,  AGOURON PHARMA

发明人： INABA TAKASHI ,  YAMADA YASUKI ,  SHANLEY JAMES ,  DEASON MICHAEL

IPC分类号： C07C319/20 ,  C07C323/25 ,  C07D317/28 ,  C07D319/20 ,  C07D321/06 ,  C07B53/00 ,  C07D303/36 ,  C07D493/04 ,  C07M7/00

CPC分类号： C07D317/28 ,  C07C319/20 ,  C07D319/20 ,  C07D321/06 ,  C07C323/25

摘要： A process for producing amide derivatives represented by general formula (XV) or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds (XV), i.e., those involving the compounds (XVI) having an HIV protease inhibitory effect in high yields. The novel intermediates are highly advantageous as intermediates for producing not only the above compounds (XVI) but also those which are useful as an X-ray contrast medium, etc.

公开(公告)号：EP1142877A4

公开(公告)日：2003-03-12

申请号：EP99961472

申请日：1999-12-28

申请人： JAPAN TOBACCO INC

发明人： INABA TAKASHI ,  KAYA TETSUDO ,  IWAMURA HIROYUKI

IPC分类号： A61P29/00 ,  A61P37/02 ,  A61P37/08 ,  C07D215/22 ,  C07D215/227 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D215/48 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/5355 ,  A61K31/706 ,  C07H15/203

CPC分类号： C07D215/227 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12

摘要： 2-Oxoquinoline compounds represented by general formula [I] or medicinally acceptable salts thereof; and medicinal uses of both (wherein each symbol is as defined in the description). The compounds [I] and the salts act selectively on cannabinoid receptors, particularly peripheral ones, little have adverse effects on the central nervous system, and exhibit excellent immunosuppressive, anti-inflammatory and antiallergic activities, thus being useful as regulators against cannabinoid receptors (particularly peripheral cannabinoid receptors), and immunosuppressive, anti-inflammatory and antiallergic agents.

公开(公告)号：EP0983999A4

公开(公告)日：2002-09-11

申请号：EP96931296

申请日：1996-09-24

申请人： JAPAN TOBACCO INC ,  AGOURON PHARMA

发明人： INABA TAKASHI ,  YAMADA YASUKI

IPC分类号： C07C319/14 ,  C07C323/25 ,  C07C323/42 ,  C07D217/26 ,  C07D263/14 ,  C07D321/06 ,  C07D413/04 ,  C07B53/00 ,  C07D493/04

CPC分类号： C07D413/04 ,  C07C319/14 ,  C07D217/26 ,  C07D263/14 ,  C07D321/06 ,  C07C323/25 ,  C07C323/42

摘要： A process for producing amide derivatives represented by general formula [XV] or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is as defined in the specification. Compared with the conventional processes, the above process can be very easily effected and enables an efficient production of the compounds [XV], i.e., those involving the compounds [XVI] having an HIV protease inhibitory effect in high yields. The n ovel intermediates are highly advantageous as intermediates for producing not only the above compounds [XVI] but also those which are useful as an X-ray contrast medium, etc.

公开(公告)号：EP0887340A4

公开(公告)日：2000-03-29

申请号：EP97902594

申请日：1997-02-06

申请人： JAPAN TOBACCO INC

发明人： INABA TAKASHI ,  KAYA TETSUDO ,  IWAMURA HIROYUKI

IPC分类号： C07C233/73 ,  C07C235/34 ,  C07C235/36 ,  C07C235/38 ,  C07C235/46 ,  C07C235/48 ,  C07C235/50 ,  C07C235/54 ,  C07C235/56 ,  C07C235/66 ,  C07C237/20 ,  C07C237/22 ,  C07C237/32 ,  C07C237/42 ,  C07C237/44 ,  C07C255/60 ,  C07C271/16 ,  C07C275/28 ,  C07C311/46 ,  C07C317/28 ,  C07C323/42 ,  C07C323/60 ,  C07C323/62 ,  C07D233/60 ,  C07D295/13 ,  C07D295/185 ,  C07D295/192 ,  A61K31/00 ,  C07C235/52

CPC分类号： C07D295/185 ,  C07C233/73 ,  C07C235/34 ,  C07C235/36 ,  C07C235/38 ,  C07C235/46 ,  C07C235/48 ,  C07C235/50 ,  C07C235/54 ,  C07C235/56 ,  C07C235/66 ,  C07C237/20 ,  C07C237/22 ,  C07C237/32 ,  C07C237/42 ,  C07C237/44 ,  C07C255/60 ,  C07C271/16 ,  C07C275/28 ,  C07C311/46 ,  C07C317/28 ,  C07C323/42 ,  C07C323/60 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/10 ,  C07D295/13 ,  C07D295/192

摘要： Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof: wherein each symbol is as define d in the specification. These compounds and salts act selectively on cannabinoid receptors, especially peripheral receptors, are reduced in the side effects against the central nervous system, and are excellent in immunomodulatory, anti-inflammatory and antiallergic activities and a nephritis curing effect, thus being useful as agonists and antagonists of cannabinoid receptors (especially peripheral cannabinoid receptors), immunomodulator, remedies for autoimmune diseases, anti-inflammatory, antiallergic, and nephritis remedy.

摘要翻译： 式（I）化合物其中每个符号如本说明书中所定义，其药学上可接受的盐和药物用途。 本发明的化合物（I）及其药学上可接受的盐选择性地作用于大麻素受体，特别是外周受体，对中枢系统产生较少的副作用，并具有优异的免疫调节作用，抗炎作用，抗过敏作用和对肾炎的治疗作用。 因此，它们可用作大麻素受体，特别是外周大麻素受体激活剂和拮抗剂，免疫调节剂，用于自身免疫性疾病的治疗剂，抗炎药，抗过敏剂和肾炎治疗剂。

公开(公告)号：EP1653969A4

公开(公告)日：2006-12-20

申请号：EP04780428

申请日：2004-08-06

申请人： JAPAN TOBACCO INC

发明人： FOX BRIAN M ,  IIO KIYOSEI ,  INABA TAKASHI ,  KAYSER FRANK ,  LI KEXUE ,  SAGAWA SHOICHI ,  TANAKA MASAHIRO ,  YOSHIDA ATSUHITO

IPC分类号： C07D487/04 ,  A01N43/58 ,  A01N43/60 ,  A61K20060101 ,  A61K31/495 ,  A61K31/497 ,  A61K31/50 ,  A61K31/503 ,  A61K31/535 ,  A61P3/00 ,  C07D237/26 ,  C07D237/28 ,  C07D413/00 ,  C07D487/00

CPC分类号： C07D487/04