公开(公告)号：EP2574631A1

公开(公告)日：2013-04-03

申请号：EP11759404.4

申请日：2011-03-23

申请人： JSR Corporation

发明人： TAMORI, Kouji ,  FUKUTA, Tetsuo ,  MIYAJI, Masaaki ,  WANG, Yong ,  ABE, Takayoshi ,  OKANO, Yusuke ,  MOMIYAMA, Masaki ,  KAWAI, Takahiro

IPC分类号： C07K17/08 ,  C07K1/22 ,  C07K19/00 ,  C12N15/09 ,  G01N30/88

CPC分类号： C07K1/22 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/288 ,  B01J20/3219 ,  B01J20/3274 ,  C07K2317/10

摘要： Provided are a filler for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. The filler for affinity chromatography is a filler in which a protein represented by the following formula (1) is immobilized on a carrier.

        R-R 2      (1)

wherein R represents an amino acid sequence consisting of 4 to 300 amino acid residues containing a region consisting of 4 to 20 contiguous histidine residues; and R 2 represents an amino acid sequence capable of binding to immunoglobulin, the amino acid sequence consisting of 50 to 500 amino acid residues containing Z domain of Protein A or a fragment thereof, or a variant thereof, provided that the R binds to C-terminus or N-terminus of the R 2 .

摘要翻译： 提供具有优异的耐碱性的亲和色谱法的填充剂和分离免疫球蛋白的方法。 用于亲和层析的填料是其中由下式（1）表示的蛋白质固定在载体上的填料。 €ƒ€ƒ€ƒ€ƒ€ƒ€ƒR-R 2€ƒ€ƒ€ƒ€ƒ（1）其中R表示由含有区域的4至300个氨基酸残基组成的氨基酸序列 由4至20个连续组氨酸残基组成; 并且R 2表示能够结合免疫球蛋白的氨基酸序列，所述氨基酸序列由含有蛋白A的Z结构域或其片段的50至500个氨基酸残基或其变体组成，条件是R与C- R 2的末端或N末端。

公开(公告)号：EP3978032A1

公开(公告)日：2022-04-06

申请号：EP20813023.7

申请日：2020-05-27

申请人： Kyoto University ,  National Cerebral and Cardiovascular Center ,  JSR Corporation

发明人： KONDO, Teruyuki ,  KIMURA, Yu ,  SON, Aoi ,  MATSUDA, Tetsuya ,  IMAI, Hirohiko ,  KOSEKI, Hirokazu ,  AOKI, Tomohiro ,  TAKASE, Katsuyuki ,  MIYAJI, Masaaki ,  TAMORI, Koji ,  MASUDA, Takeaki ,  KAI, Hirokazu

IPC分类号： A61K49/08 ,  A61B5/055

摘要： Composite particles, each of which is obtained by forming, on the surface of a gadolinium oxide-containing particle, a cover film that contains a polymer obtained by polymerizing a monomer component containing a monomer having an ethylenically unsaturated bond; a macrophage imaging agent which contains the composite particles; and a method for producing composite particles, wherein a monomer component containing a monomer having an ethylenically unsaturated bond and gadolinium oxide-containing particles are mixed with each other, and after emulsifying the thus-obtained monomer component-containing mixture in water in the presence of a surfactant and a polymerization initiator in water, the monomer component is polymerized, thereby forming cover films on the surfaces of the gadolinium oxide-containing particles.

公开(公告)号：EP2339339A1

公开(公告)日：2011-06-29

申请号：EP09816172.2

申请日：2009-09-24

申请人： JSR Corporation

发明人： TAMORI, Kouji ,  FUKUTA, Tetsuo ,  MIYAJI, Masaaki ,  WANG, Yong ,  ABE, Takayoshi ,  OKANO, Yuusuke ,  MOMIYAMA, Masaki ,  KAWAI, Takahiro

IPC分类号： G01N30/88 ,  C07K14/31

CPC分类号： C07K1/22 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3219 ,  B01J20/3274 ,  Y10T428/29

摘要： An affinity chromatography packing material includes porous mother particles that include a copolymer of a monomer mixture including a crosslinkable vinyl monomer and an epoxy group-containing vinyl monomer, a ligand being bound to the porous mother particles, and the porous mother particles including a ring-opening epoxy group produced by ring-opening of the epoxy group included in the porous mother particles.

摘要翻译： 亲和层析填充材料包括多孔母体颗粒，其包括包含可交联乙烯基单体和含环氧基的乙烯基单体的单体混合物的共聚物，与多孔母体颗粒结合的配体，以及多孔母体颗粒， 开环环氧基，其由包含在多孔母体颗粒中的环氧基开环制备。