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22 条记录 (耗时 0.021 秒)

    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY
    1.
    发明公开
    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权
    PEPTIDFRAGMENTE MIT DEN ZELLTOD VERHINDERNDERAKTIVITÄT

    公开(公告)号：EP1132402A1

    公开(公告)日：2001-09-12

    申请号：EP99972642.5

    申请日：1999-11-12

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： HIRASHIMA, Masaki ,  MAEDA, Hiroaki ,  NOZAKI, Chikateru

    IPC分类号： C07K14/47 ,  A61K38/17 ,  C12N5/06 ,  C07K16/18

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.

    摘要翻译： 本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有由硒蛋白P的C末端上的103个氨基酸残基组成的氨基酸序列，或具有所述氨基酸序列与一个或多个 其中缺少，取代或添加的几个氨基酸残基或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列 的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。 本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。

    MUTANT TRANSPOSON VECTOR AND USE THEREOF
    2.
    发明授权
    MUTANT TRANSPOSON VECTOR AND USE THEREOF 有权
    突变体转座子及其用途

    公开(公告)号：EP1921140B1

    公开(公告)日：2011-12-14

    申请号：EP06780756.0

    申请日：2006-07-04

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： KAMINAKA, Kazuyoshi ,  MAEDA, Hiroaki ,  HIRASHIMA, Masaki ,  KAWAMURA, Ryoichi ,  MATSUDA, Junichi ,  KUWANA, Takashi

    IPC分类号： C12N15/09 ,  A01K67/027 ,  C12N5/10

    CPC分类号： C12N15/79 ,  A01K2217/05 ,  A01K2227/30 ,  C12N15/102 ,  C12N15/85 ,  C12N15/90 ,  C12N2800/30 ,  C12N2800/90 ,  C12N2820/00

    摘要： Disclosed are a mutant transposon vector and a method for introducing a foreign gene into a cell. A mutant transposon vector having a nucleic acid fragment inserted therein, the nucleic acid fragment having the properties (i) and (ii) or the properties (i) to (iii) below; a foreign gene-expressing cell which is prepared by introducing the mutant transposon vector into the chromosomal DNA of an established cell or a cell capable of being individuated and then additionally introducing a foreign gene-expressing cassette into a recombinant system (e.g., Cre-Lox system); a recombinant animal created by using the cell (in the case where the cell capable of being individuated is used); and a method for producing a foreign protein from the cell or the recombinant animal: (i) comprising a 5'-TIR sequence and a 3'-TIR sequence of transposon gene; (ii) having a sequence at which a recombination reaction occurs inserted between at least one set of DR regions of two sets of DR regions present in a 5'-TIR sequence or a 3'-TIR sequence of transposon gene; and (iii) having a restriction recognition site or a foreign gene-expressing cassette inserted between a 5'-TIR sequence and a 3'-TIR sequence of transposon gene.

    ANTI-HIV MONOCLONAL ANTIBODY
    4.
    发明授权
    ANTI-HIV MONOCLONAL ANTIBODY 失效
    单克隆抗HIV抗体

    公开(公告)号：EP0690132B1

    公开(公告)日：2003-12-17

    申请号：EP94909286.0

    申请日：1994-03-09

    申请人： JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE

    发明人： EDA, Yasuyuki ,  MAEDA, Hiroaki ,  MAKIZUMI, Keiichi ,  SHIOSAKI, Kouichi ,  OSATOMI, Kiyoshi ,  KIMACHI, Kazuhiko ,  HIGUCHI, Hirofumi ,  TOKIYOSHI, Sachio

    IPC分类号： C12P21/08 ,  C07K14/16

    CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2317/24

    摘要： The invention provides a clinically useful monoclonal antibody which can recognize the conserved region of the V3-PND region of a glycoprotein antigen (gp120) having a molecular weight of about 120,000 Da and contained in the coat of a human immunodefiency virus (HIV) and which can neutralize a wide variety of HIV variants, or a fragment of the above antibody, and chimera and humanized antibodies derived from the above antibody. It is possible to prepare a monoclonal antibody having the activity of neutralizing various HIV variants by using as the immunogen several types of peptides having a PND tip region containing a GPGR sequence having a high conservability in the PND region of the gp120 of an HIV. It is possible to obtain a chimera antibody or an altered antibody having an anti-HIV neutralization activity effective for clinical application by transplanting a fragment of a gene coding for the variable region of the above monoclonal antibody or the complementarity-determining region of that region to a human antibody gene.

    RECOMBINANT ANTI-HIV ANTIBODY AND PREPARATION THEREOF
    5.
    发明公开
    RECOMBINANT ANTI-HIV ANTIBODY AND PREPARATION THEREOF 失效
    REKOMBINANTER抗艾滋病毒抗体在SEINE HERSTELLUNG下。

    公开(公告)号：EP0678523A1

    公开(公告)日：1995-10-25

    申请号：EP93901547.5

    申请日：1993-01-14

    申请人： JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE

    发明人： MAEDA, Hiroaki ,  KIMACHI, Kazuhiko ,  EDA, Yasuyuki ,  SHIOSAKI, Kouichi ,  OSATOMI, Kiyoshi Pana Haitsu 102 ,  TOKIYOSHI, Sachio

    IPC分类号： C07K15/28 ,  C12P21/08 ,  C12N15/13

    CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2319/00

    摘要： The invention relates to a gene fragment which codes for the variable regions of an antibody having an activity of neutralizing human immunodeficiency virus (HIV), a novel recombinant anti-HIV antibody expressed by using the above gene, and a process for preparing the same. A mouse-human chimeric antibody and a modified mouse-human antibody, having an activity of neutralizing HIV, are obtained by determining a specific nucleic acid sequence of a gene fragment which codes for the variable regions of the H and L chains of an antibody having an activity of neutralizing HIV and artificially fusing a DNA synthesized on the basis of the determined sequence with a gene which codes for human immunoglobulin. The novel anti-HIV antibody is useful for treating and preventing AIDS.

    摘要翻译： 本发明涉及编码具有中和人免疫缺陷病毒（HIV）活性的抗体的可变区的基因片段，使用上述基因表达的新型重组抗HIV抗体及其制备方法。 具有中和HIV活性的小鼠 - 人嵌合抗体和修饰的小鼠 - 人抗体通过确定编码具有下列特征的抗体的H链和L链的可变区的基因片段的特定核酸序列来获得： 中和HIV并基于确定的序列合成的DNA与编码人免疫球蛋白的基因人工融合的活性。 新型抗HIV抗体可用于治疗和预防艾滋病。

    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY
    7.
    发明授权
    PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权
    与细胞死亡抑制活性肽片段

    公开(公告)号：EP1132402B1

    公开(公告)日：2009-05-27

    申请号：EP99972642.5

    申请日：1999-11-12

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： HIRASHIMA, Masaki ,  MAEDA, Hiroaki ,  NOZAKI, Chikateru

    IPC分类号： C07K14/47 ,  A61K38/17 ,  C12N5/06 ,  C07K16/18

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： Peptide fragment(s) having an activity of inhibiting cell death which contain the amino acid sequence consisting of 103 amino acid residues in the C-terminal side of selenoprotein P, an amino acid sequence derived from the above amino acid sequence by deletion, substitution or addition of one or several amino acids therein, or a partial sequence of either of the above amino acid sequences; remedies containing the above peptide fragment(s); antibodies against the above peptide fragment(s); and a method for screening a cell death inhibitory activity with the use of the above peptide fragment(s). Preferable examples of the above peptide fragment(s) are those containing the amino acid sequence(s) represented by SEQ ID NO:1 and/or 2 or partial sequences thereof.

    NOVEL FELINE CYTOKINE PROTEIN
    9.
    发明公开
    NOVEL FELINE CYTOKINE PROTEIN 失效
    CYTOKIN-PROTEIN AUS KATZEN

    公开(公告)号：EP0850951A1

    公开(公告)日：1998-07-01

    申请号：EP97924250.0

    申请日：1997-05-29

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： IMAMURA, Takayuki ,  MAEDA, Hiroaki ,  FUJIYASU, Takeshi ,  IMAGAWA, Yoshitaka ,  TOKIYOSHI, Sachio

    IPC分类号： C07K14/52 ,  C07K16/24 ,  C12N15/24 ,  C12N5/16 ,  C12P21/02 ,  C12P21/08 ,  A61K38/20

    CPC分类号： C07K14/52 ,  A61K38/00

    摘要： A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinant DNA, a transformant which is transformed with said expression vector, a process for preparing said protein by culturing said transformant, and an antibody against said protein are provided. The novel feline cytokine protein of the present invention is a heterologous dimer comprising FLAF p35 and FLAF p40 and can be used for treating feline infectious diseases such as feline herpes virus type 1 (FHV-1) or feline calicivirus (FCV).

    摘要翻译： 一种具有增强猫细胞毒性T淋巴细胞的细胞毒活性的活性的新型猫科动物细胞因子蛋白，编码所述蛋白质的DNA序列，用于表达所述蛋白的重组DNA，包含所述重组DNA的表达载体，用所述重组DNA转化的转化体 表达载体，通过培养所述转化体制备所述蛋白质的方法和针对所述蛋白质的抗体。 本发明的新型猫科动物细胞因子蛋白是包含FLAF p35和FLAF p40的异源二聚体，可用于治疗猫传染病如1型（FHV-1）或猫杯状病毒（FCV）的猫疱疹病毒。