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1.发明公开NOVEL PREVENTIVES/REMEDIES FOR IMMUNOPATHY 审中-公开NEUE VORBEUGUNGSMEDIZIN / HEILMITTELFÜRIMMUNOPATHIEN
公开(公告)号：EP1055429A1
公开(公告)日：2000-11-29
申请号：EP99902905.1
申请日：1999-02-15
发明人： SASAKI, Takumi , KIMACHI, Kazuhiko , SOEJIMA, Kenji , KIMURA, Yumi , NOZAKI, Chikateru , FUJIYAMA, Yoshihide
CPC分类号： C07K14/31 , A61K38/164 , A61K39/085
摘要： A prophylactic/remedy for immunopathy for immunopathy comprising, as an active ingredient, modifications of Staphylococcal enterotoxin B (SEB) with substitution of at least one amino acid residues within the amino acid sequence of natural type SEB, or derivatives thereof, wherein said SEB modifications or derivatives thereof have inhibitory activity on T cell activation wherein they interact with specific Vβ component of T cell receptor (TCR) but are reduced in their immunological responsiveness to SEB without inducing elimination of T cells having specific Vβ component, the elimination being normally induced by natural type SEB or recombinant wild-type SEB.
摘要翻译： 作为免疫疾病免疫病的预防/治疗方法，其包含用天然型SEB的氨基酸序列中的至少一个氨基酸残基取代的葡萄球菌肠毒素B（SEB）或其衍生物作为活性成分的修饰，其中所述SEB修饰 或其衍生物对T细胞活化具有抑制活性，其中它们与T细胞受体（TCR）的特异性Vβ组分相互作用，但其对SEB的免疫应答降低，而不诱导具有特异性Vβ组分的T细胞的消除，消除正常 由天然型SEB或重组野生型SEB诱导。
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公开(公告)号：EP0678523B1
公开(公告)日：2004-09-15
申请号：EP93901547.5
申请日：1993-01-14
发明人： MAEDA, Hiroaki , KIMACHI, Kazuhiko , EDA, Yasuyuki , SHIOSAKI, Kouichi , OSATOMI, Kiyoshi Pana Haitsu 102 , TOKIYOSHI, Sachio
IPC分类号： C07K16/10 , A61K39/395 , C12P21/08 , C12N15/13
CPC分类号： C07K16/1063 , A61K38/00 , C07K2319/00
摘要： The invention relates to a gene fragment which codes for the variable regions of an antibody having an activity of neutralizing human immunodeficiency virus (HIV), a novel recombinant anti-HIV antibody expressed by using the above gene, and a process for preparing the same. A mouse-human chimeric antibody and a modified mouse-human antibody, having an activity of neutralizing HIV, are obtained by determining a specific nucleic acid sequence of a gene fragment which codes for the variable regions of the H and L chains of an antibody having an activity of neutralizing HIV and artificially fusing a DNA synthesized on the basis of the determined sequence with a gene which codes for human immunoglobulin. The novel anti-HIV antibody is useful for treating and preventing AIDS.
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公开(公告)号：EP0690132B1
公开(公告)日：2003-12-17
申请号：EP94909286.0
申请日：1994-03-09
发明人： EDA, Yasuyuki , MAEDA, Hiroaki , MAKIZUMI, Keiichi , SHIOSAKI, Kouichi , OSATOMI, Kiyoshi , KIMACHI, Kazuhiko , HIGUCHI, Hirofumi , TOKIYOSHI, Sachio
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： The invention provides a clinically useful monoclonal antibody which can recognize the conserved region of the V3-PND region of a glycoprotein antigen (gp120) having a molecular weight of about 120,000 Da and contained in the coat of a human immunodefiency virus (HIV) and which can neutralize a wide variety of HIV variants, or a fragment of the above antibody, and chimera and humanized antibodies derived from the above antibody. It is possible to prepare a monoclonal antibody having the activity of neutralizing various HIV variants by using as the immunogen several types of peptides having a PND tip region containing a GPGR sequence having a high conservability in the PND region of the gp120 of an HIV. It is possible to obtain a chimera antibody or an altered antibody having an anti-HIV neutralization activity effective for clinical application by transplanting a fragment of a gene coding for the variable region of the above monoclonal antibody or the complementarity-determining region of that region to a human antibody gene.
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4.发明公开
公开(公告)号：EP0678523A1
公开(公告)日：1995-10-25
申请号：EP93901547.5
申请日：1993-01-14
发明人： MAEDA, Hiroaki , KIMACHI, Kazuhiko , EDA, Yasuyuki , SHIOSAKI, Kouichi , OSATOMI, Kiyoshi Pana Haitsu 102 , TOKIYOSHI, Sachio
CPC分类号： C07K16/1063 , A61K38/00 , C07K2319/00
摘要： The invention relates to a gene fragment which codes for the variable regions of an antibody having an activity of neutralizing human immunodeficiency virus (HIV), a novel recombinant anti-HIV antibody expressed by using the above gene, and a process for preparing the same. A mouse-human chimeric antibody and a modified mouse-human antibody, having an activity of neutralizing HIV, are obtained by determining a specific nucleic acid sequence of a gene fragment which codes for the variable regions of the H and L chains of an antibody having an activity of neutralizing HIV and artificially fusing a DNA synthesized on the basis of the determined sequence with a gene which codes for human immunoglobulin. The novel anti-HIV antibody is useful for treating and preventing AIDS.
摘要翻译： 本发明涉及编码具有中和人免疫缺陷病毒（HIV）活性的抗体的可变区的基因片段，使用上述基因表达的新型重组抗HIV抗体及其制备方法。 具有中和HIV活性的小鼠 - 人嵌合抗体和修饰的小鼠 - 人抗体通过确定编码具有下列特征的抗体的H链和L链的可变区的基因片段的特定核酸序列来获得： 中和HIV并基于确定的序列合成的DNA与编码人免疫球蛋白的基因人工融合的活性。 新型抗HIV抗体可用于治疗和预防艾滋病。
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公开(公告)号：EP0690132A1
公开(公告)日：1996-01-03
申请号：EP94909286.0
申请日：1994-03-09
发明人： EDA, Yasuyuki , MAEDA, Hiroaki , MAKIZUMI, Keiichi , SHIOSAKI, Kouichi , OSATOMI, Kiyoshi , KIMACHI, Kazuhiko , HIGUCHI, Hirofumi , TOKIYOSHI, Sachio
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： The invention provides a clinically useful monoclonal antibody which can recognize the conserved region of the V3-PND region of a glycoprotein antigen (gp120) having a molecular weight of about 120,000 Da and contained in the coat of a human immunodefiency virus (HIV) and which can neutralize a wide variety of HIV variants, or a fragment of the above antibody, and chimera and humanized antibodies derived from the above antibody. It is possible to prepare a monoclonal antibody having the activity of neutralizing various HIV variants by using as the immunogen several types of peptides having a PND tip region containing a GPGR sequence having a high conservability in the PND region of the gp120 of an HIV. It is possible to obtain a chimera antibody or an altered antibody having an anti-HIV neutralization activity effective for clinical application by transplanting a fragment of a gene coding for the variable region of the above monoclonal antibody or the complementarity-determining region of that region to a human antibody gene.
摘要翻译： 本发明提供临床有用的单克隆抗体，其可以识别分子量为约120,000Da且包含在人免疫缺陷病毒（HIV）的外壳中的糖蛋白抗原（gp120）的V3-PND区域的保守区域，并且其中 可以中和各种HIV变体，或上述抗体的片段，以及衍生自上述抗体的嵌合体和人源化抗体。 可以制备具有中和各种HIV变异体的活性的单克隆抗体，该单克隆抗体具有在HIV的gp120的PND区域中具有包含具有高保守性的GPGR序列的PND末端区域的几种类型的肽作为免疫原。 可以通过将编码上述单克隆抗体的可变区的基因的片段或该区域的互补决定区域移植到具有对临床应用有效的抗HIV中和活性的嵌合体抗体或改变的抗体 人抗体基因。
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6.发明公开ANTI-FELINE HERPESVIRUS-1 RECOMBINANT ANTIBODY AND GENE FRAGMENT CODING FOR SAID ANTIBODY 失效重组抗体针对猫疱疹病毒-1基因片段和编码它们。
公开(公告)号：EP0671472A1
公开(公告)日：1995-09-13
申请号：EP94901002.9
申请日：1993-11-25
CPC分类号： C07K16/085 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S424/80 , Y10S424/801 , Y10S424/809
摘要： An anti-feline herpesvirus-1 recombinant antibody which is efficacious in treating, preventing and diagnosing feline herpesvirus-1 (FHV-1) infection, and a gene fragment useful for the preparation of the antibody. A gene fragment coding for the antibody V region bearing an FHV-1 specific avidity of a mouse monoclonal antibody having an excellent activity of neutralizing FHV-1 is obtained by constructing cells which produce the antibody. A chimeric anti-FHV-1 recombinant antibody is prepared from the above gene fragment and another gene fragment coding for a feline antibody C region.
摘要翻译： 抗猫疱疹病毒-1重组抗体的所有这是在治疗，预防和诊断猫疱疹病毒-1（FHV-1）感染是有效的，和对抗体的制备中有用的基因片段。 的基因片段编码用于在具有中和FHV-1是通过构造其中产生抗体的细胞获得的优异活性的小鼠单克隆抗体的FHV-1特异性亲合力的抗体V区的轴承。 嵌合的抗FHV-1重组抗体是由上述基因片段和猫科动物抗体C区的另一种基因片段编码制备。
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7.发明授权ANTI-FELINE HERPESVIRUS-1 RECOMBINANT ANTIBODY AND GENE FRAGMENT CODING FOR SAID ANTIBODY 失效重组抗体针对猫疱疹病毒-1和基因片段编码它们
公开(公告)号：EP0671472B1
公开(公告)日：2001-03-14
申请号：EP94901002.9
申请日：1993-11-25
CPC分类号： C07K16/085 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S424/80 , Y10S424/801 , Y10S424/809
摘要： An anti-feline herpesvirus-1 recombinant antibody which is efficacious in treating, preventing and diagnosing feline herpesvirus-1 (FHV-1) infection, and a gene fragment useful for the preparation of the antibody. A gene fragment coding for the antibody V region bearing an FHV-1 specific avidity of a mouse monoclonal antibody having an excellent activity of neutralizing FHV-1 is obtained by constructing cells which produce the antibody. A chimeric anti-FHV-1 recombinant antibody is prepared from the above gene fragment and another gene fragment coding for a feline antibody C region.
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公开(公告)号：EP0671471B1
公开(公告)日：1999-04-07
申请号：EP94901001.1
申请日：1993-11-25
CPC分类号： C12N15/85 , C07K16/00 , C12N2840/20 , C12N2840/44
摘要： A process for efficiently producing a foreign protein, in particular, a novel foreign protein suitable for the expression of a recombinant antibody with eucaryotic cells by the genetic recombination techniques, wherein a cell containing a foreign gene introduced thereinto can be cultured in a serum-free medium by using as a host cell for foreign gene expression a fused cell obtained by the fusion of mouse myeloma with a lymphoid cell and culturable in a serum-free medium.
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公开(公告)号：EP0671471A1
公开(公告)日：1995-09-13
申请号：EP94901001.1
申请日：1993-11-25
CPC分类号： C12N15/85 , C07K16/00 , C12N2840/20 , C12N2840/44
摘要： A process for efficiently producing a foreign protein, in particular, a novel foreign protein suitable for the expression of a recombinant antibody with eucaryotic cells by the genetic recombination techniques, wherein a cell containing a foreign gene introduced thereinto can be cultured in a serum-free medium by using as a host cell for foreign gene expression a fused cell obtained by the fusion of mouse myeloma with a lymphoid cell and culturable in a serum-free medium.
摘要翻译： 一种有效生产外源蛋白质的方法，特别是适用于通过遗传重组技术用真核细胞表达重组抗体的新颖外源蛋白质，其中含有外源基因的细胞可以在无血清培养 通过使用通过小鼠骨髓瘤与淋巴样细胞融合而获得的融合细胞作为外源基因表达的宿主细胞，并在无血清培养基中培养的培养基。
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