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1.发明公开
公开(公告)号：EP3655026A2
公开(公告)日：2020-05-27
申请号：EP18835568.9
申请日：2018-07-17
发明人： HUANG, Chichi , LEE, John , MOONEY, Jill , NASO, Michael
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2.发明公开PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) BISPECIFIC BINDING AGENTS AND USES THEREOF 审中-公开前列腺特异性膜抗原（PSMA）双特异性结合剂及其用途
公开(公告)号：EP3291836A2
公开(公告)日：2018-03-14
申请号：EP16790175.0
申请日：2016-05-06
发明人： ANDERSON, Glenn , CARDOSO, Rosa , DIEM, Michael , GAUDET, Francois , GOLDBERG, Shalom , HARMAN, Benjamin C. , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer , O'NEIL, Karyn , POMERANTZ, Steven C. , CHANDRA RAO, Galla , SPINKA-DOMS, Tracy , TEPLYAKOV, Alexey , WU, Sheng-Jiun , MOONEY, Jill , LUISTRO, Leopoldo
IPC分类号： A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28
CPC分类号： C07K16/2809 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K49/0045 , A61K49/0058 , A61K2039/505 , C07K14/78 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C12Y304/17021
摘要： Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
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3.发明公开
公开(公告)号：EP3724321A1
公开(公告)日：2020-10-21
申请号：EP18888643.6
申请日：2018-12-11
发明人： LEE, John , MOONEY, Jill , NASO, Michael
IPC分类号： C12N5/0783 , C07K16/28 , C07K14/725 , C07K14/74 , A61K35/17 , A61P35/00
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4.发明公开
公开(公告)号：EP3512541A1
公开(公告)日：2019-07-24
申请号：EP17772529.8
申请日：2017-09-11
发明人： CHIN, Chen Ni , LEE, John , MCCABE, Timothy , MOONEY, Jill , NASO, Michael , STROHL, William
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