-
公开(公告)号：EP3463430A1
公开(公告)日：2019-04-10
申请号：EP17807478.7
申请日：2017-06-01
发明人： DIEM, Michael , JACOBS, Steven , O'NEIL, Karyn , RUTKOSKI, Thomas
-
公开(公告)号：EP3128048B1
公开(公告)日：2018-11-28
申请号：EP16176749.6
申请日：2009-10-27
发明人： JACOBS, Steven , O'NEIL, Karyn
摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
-
公开(公告)号：EP2494062B1
公开(公告)日：2016-12-28
申请号：EP10828884.6
申请日：2010-10-27
发明人： O'NEIL, Karyn , PICHA, Kristen
CPC分类号： C07K16/2869 , C07K2317/76
-
公开(公告)号：EP3724127A1
公开(公告)日：2020-10-21
申请号：EP18887822.7
申请日：2018-12-14
-
公开(公告)号：EP3485901A1
公开(公告)日：2019-05-22
申请号：EP18197990.7
申请日：2013-11-21
发明人： ANDERSON, Mark , ATTAR, Ricardo , DIEM, Michael , HYUN, Linus , JACOBS, Steven , KING, Alastair , KLEIN, Donna , MOORES, Sheri , O'NEIL, Karyn , PICHA, Kristen
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
-
6.发明公开PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) BISPECIFIC BINDING AGENTS AND USES THEREOF 审中-公开前列腺特异性膜抗原（PSMA）双特异性结合剂及其用途
公开(公告)号：EP3291836A2
公开(公告)日：2018-03-14
申请号：EP16790175.0
申请日：2016-05-06
发明人： ANDERSON, Glenn , CARDOSO, Rosa , DIEM, Michael , GAUDET, Francois , GOLDBERG, Shalom , HARMAN, Benjamin C. , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer , O'NEIL, Karyn , POMERANTZ, Steven C. , CHANDRA RAO, Galla , SPINKA-DOMS, Tracy , TEPLYAKOV, Alexey , WU, Sheng-Jiun , MOONEY, Jill , LUISTRO, Leopoldo
IPC分类号： A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28
CPC分类号： C07K16/2809 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K49/0045 , A61K49/0058 , A61K2039/505 , C07K14/78 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C12Y304/17021
摘要： Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
-
公开(公告)号：EP3471750A2
公开(公告)日：2019-04-24
申请号：EP17816128.7
申请日：2017-06-21
-
8.发明公开PROSTATE SPECIFIC MEMBRANE ANTIGEN BINDING FIBRONECTIN TYPE III DOMAINS 审中-公开前列腺特异性膜抗原结合纤连蛋白III型结构域
公开(公告)号：EP3292222A2
公开(公告)日：2018-03-14
申请号：EP16790187.5
申请日：2016-05-06
发明人： CARDOSO, Rosa , DIEM, Michael , GOLDBERG, Shalom , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , O'NEIL, Karyn , SPINKA-DOMS, Tracy
IPC分类号： C12Q1/68
CPC分类号： C07K14/78 , A61K38/00 , A61K51/08 , G01N33/57434 , G01N2333/705
摘要： PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
-
9.发明公开FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES 审中-公开澳大利亚FIBRONECTIN-TYP-III-DOMAIN BASIERENDEGERÜSTZUSAMMENSETZUNGEN，VERFAHREN UND VERWENDUNG
公开(公告)号：EP3128048A1
公开(公告)日：2017-02-08
申请号：EP16176749.6
申请日：2009-10-27
发明人： JACOBS, Steven , O'NEIL, Karyn
摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
摘要翻译： 基于纤连蛋白III型（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。
-
10.发明授权FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES 有权纤连蛋白III型基于域的支架组合物，方法和用途
公开(公告)号：EP2356269B1
公开(公告)日：2016-06-29
申请号：EP09824067.4
申请日：2009-10-27
发明人： JACOBS, Steven , O'NEIL, Karyn
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.019 秒)
