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公开(公告)号：EP2297089B1
公开(公告)日：2013-07-31
申请号：EP09738096.8
申请日：2009-04-27
发明人： SCHOENTJES, Bruno , PONCELET, Alain, Philippe , DOYON, Julien, Georges, Pierre-Olivier , LINDERS, Joannes, Theodorus, Maria , MEERPOEL, Lieven , VER DONCK, Luc, August, Laurentius
IPC分类号： C07D313/08 , C07C35/52 , C07C43/192 , C07C215/42 , C07C215/64 , C07C217/08 , C07C217/74 , C07D405/04 , C07D407/04 , C07D295/092
CPC分类号： C07C215/42 , C07C35/52 , C07C43/192 , C07C215/64 , C07C217/08 , C07C217/74 , C07C2602/12 , C07D207/06 , C07D213/53 , C07D213/65 , C07D215/14 , C07D239/26 , C07D295/092 , C07D295/096 , C07D295/16 , C07D313/08 , C07D317/58 , C07D405/04 , C07D407/04
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公开(公告)号：EP2001868B1
公开(公告)日：2013-07-17
申请号：EP07727057.7
申请日：2007-03-19
发明人： LACRAMPE, Jean, Fernand, Armand , MEYER, Christophe , SCHOENTJES, Bruno , LARDEAU, Delphine, Yvonne, Raymonde , PONCELET, Alain, Philippe , VAN HIJFTE, Luc
IPC分类号： C07D401/12 , C07D405/12 , C07D471/04 , A61K31/4409 , A61P35/00
CPC分类号： C07D405/12 , C07D401/12 , C07D471/04
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3.发明公开CYCLIC-ALKYLAMINEDERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 有权BETWEEN MDM2与p53相互作用的CYCLOALKYLAMINDERIVATE作为抑制剂
公开(公告)号：EP1999126A1
公开(公告)日：2008-12-10
申请号：EP07727060.1
申请日：2007-03-19
发明人： LACRAMPE, Jean, Fernand, Armand , MEYER, Christophe , SCHOENTJES, Bruno , PONCELET, Alain, Philippe , WERMUTH, Camille, Georges , GIETHLEN, Bruno , CONTRERAS, Jean-Marie , JOUBERT, Muriel , VAN HIJFTE, Luc
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/14
摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1 , R2 , R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
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公开(公告)号：EP3126364A1
公开(公告)日：2017-02-08
申请号：EP15713522.9
申请日：2015-04-02
发明人： DIELS, Gaston, Stanislas, Marcella , SCHOENTJES, Bruno , VERSELE, Matthias, Luc, Aimé , BERTHELOT, Didier, Jean-Claude , WILLEMS, Marc , VIELLEVOYE, Marcel , EMBRECHTS, Werner, Constant, Johan , WROBLOWSKI, Berthold , MEERPOEL, Lieven
IPC分类号： C07D471/22 , C07D498/22 , A61K31/505 , A61P35/00
CPC分类号： C07D471/22 , C07D498/22 , Y02P20/582
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 其中变量具有在权利要求中限定的含义。 根据本发明的化合物具有EF2K抑制活性和任选的Vps34抑制活性。 本发明还涉及制备这些新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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5.发明授权Substituted phenylenediamines as inhibitors of the interaction between MDM2 and p53 有权取代的苯二胺作为MDM2与p53之间的相互作用的抑制剂
公开(公告)号：EP2185541B1
公开(公告)日：2015-01-28
申请号：EP08786899.8
申请日：2008-08-05
发明人： PONCELET, Alain Philippe , SCHOENTJES, Bruno , STORCK, Pierre-Henri , PONCELET, Virginie Sophie , LEYS, Carina
IPC分类号： C07D401/12 , A61K31/435 , A61K31/4045 , A61P35/00
CPC分类号： C07D401/12
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公开(公告)号：EP2393801A2
公开(公告)日：2011-12-14
申请号：EP10702310.3
申请日：2010-02-03
IPC分类号： C07D401/12 , A61K31/435 , A61K31/44 , A61P35/00
CPC分类号： C07D401/12
摘要： The present invention provides compounds of formula (I), their use for the treatment of cancer as well as pharmaceutical compositions comprising said compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其用于治疗癌症的用途以及包含所述式（I）化合物的药物组合物。
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7.发明授权CYCLIC-ALKYLAMINEDERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 有权BETWEEN MDM2与p53相互作用的CYCLOALKYLAMINDERIVATE作为抑制剂
公开(公告)号：EP1999126B1
公开(公告)日：2010-06-09
申请号：EP07727060.1
申请日：2007-03-19
发明人： LACRAMPE, Jean, Fernand, Armand , MEYER, Christophe , SCHOENTJES, Bruno , PONCELET, Alain, Philippe , WERMUTH, Camille, Georges , GIETHLEN, Bruno , CONTRERAS, Jean-Marie , JOUBERT, Muriel , VAN HIJFTE, Luc
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/14
摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1 , R2 , R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
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公开(公告)号：EP3126364B1
公开(公告)日：2018-02-07
申请号：EP15713522.9
申请日：2015-04-02
发明人： DIELS, Gaston, Stanislas, Marcella , SCHOENTJES, Bruno , VERSELE, Matthias, Luc, Aimé , BERTHELOT, Didier, Jean-Claude , WILLEMS, Marc , VIELLEVOYE, Marcel , EMBRECHTS, Werner, Constant, Johan , WROBLOWSKI, Berthold , MEERPOEL, Lieven
IPC分类号： C07D471/22 , C07D498/22 , A61K31/505 , A61P35/00
CPC分类号： C07D471/22 , C07D498/22 , Y02P20/582
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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公开(公告)号：EP3126365A1
公开(公告)日：2017-02-08
申请号：EP15713523.7
申请日：2015-04-02
发明人： DIELS, Gaston, Stanislas, Marcella , SCHOENTJES, Bruno , VERSELE, Matthias, Luc, Aimé , BERTHELOT, Didier, Jean-Claude , WILLEMS, Marc , VIELLEVOYE, Marcel , SOMMEN, François, Maria , WROBLOWSKI, Berthold , MEERPOEL, Lieven
IPC分类号： C07D471/22 , C07D498/22 , A61K31/505 , A61P35/00
CPC分类号： C07D471/22 , C07D491/22 , C07D498/22 , C07D513/22 , Y02P20/582
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 其中变量具有在权利要求中限定的含义。 根据本发明的化合物具有EF2K抑制活性和任选的Vps34抑制活性。 本发明还涉及制备这些新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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公开(公告)号：EP2203447B1
公开(公告)日：2012-02-29
申请号：EP08804483.9
申请日：2008-09-19
发明人： STORCK, Pierre-Henri , SCHOENTJES, Bruno , PIETTRE, Arnaud Marcel Pierre , ERMERT, Philipp , PONCELET, Virginie Sophie , CSOKA, Imre Christian Francis
IPC分类号： C07D413/14 , A61K31/538 , A61P35/00
CPC分类号： C07D413/14
摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, s, t, R1, R2, R3, R4, R5, X, Y, Q, Z, G, E and D have defined meanings.
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