公开(公告)号：EP3481394A1

公开(公告)日：2019-05-15

申请号：EP17748965.5

申请日：2017-07-06

申请人： Janssen Pharmaceutica N.V.

发明人： BIGNAN, Gilles C. ,  BRANCH, Jonathan ,  ESCOLAR, Luis B Trabalon ,  CONNOLLY, Peter J. ,  MEERPPOEL, Lieven ,  ROCOBOY, Christian ,  PANDE, Vineet ,  HICKSON, Ian ,  ZHANG, Zhuming

IPC分类号： A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00

公开(公告)号：EP3481813A1

公开(公告)日：2019-05-15

申请号：EP17743115.2

申请日：2017-07-06

申请人： Janssen Pharmaceutica N.V.

发明人： BIGNAN, Gilles C. ,  CONNOLY, Peter J. ,  BRANCH, Jonathan ,  TRABALON ESCOLAR, Luis B ,  MEERPOEL, Lieven ,  HICKSON, Ian ,  PANDE, Vineet ,  ZHANG, Zhuming ,  ROCOBOY, Christian

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61P35/00 ,  A61K31/454 ,  A61K31/506 ,  A61K31/4545

公开(公告)号：EP2892892A1

公开(公告)日：2015-07-15

申请号：EP13762696.6

申请日：2013-09-06

申请人： Janssen Pharmaceutica N.V.

发明人： BIGNAN, Gilles C. ,  CONNOLLY, Peter J. ,  LU, Tianbao L. ,  PARKER, Michael H. ,  LUDOVICI, Donald ,  MEYER, Christophe ,  MEERPOEL, Lieven ,  SMANS, Karine ,  ROCABOY, Christian

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04 ,  A61K31/4184 ,  A61K31/4188

CPC分类号： C07D417/14 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04

摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L
1 , a, b, m, n, R
1 , R
2 , R
3 , R
4 , and R
5 are defined herein.

摘要翻译： 本发明公开了化合物，组合物和方法用于治疗各种疾病，综合征，病症和障碍，包括那些通过抑制脂肪酸合酶（FASN）的酶介导的：如，癌症，肥胖症或相关盘订单，肝相关疾病。 搜索化合物由式（I）表示如下：其中L 1，A，B，M，N，R1，R2，R3，R4，和R5中的定义。

公开(公告)号：EP2134698A1

公开(公告)日：2009-12-23

申请号：EP08731528.9

申请日：2008-03-06

申请人： Janssen Pharmaceutica, N.V.

发明人： GAUL, Michael ,  KIM, Alexander ,  SEARLE, Lily Lee ,  RENTZEPERIS, Dionisios ,  BIGNAN, Gilles C.

IPC分类号： C07D277/34 ,  C07D417/04 ,  A61K31/427 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D277/34 ,  C07D417/04

摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.