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1.发明授权TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS 有权四氢噻蒽和四氢环戊烯醇作为PARP和微管聚合抑制剂
公开(公告)号：EP2271626B1
公开(公告)日：2014-11-26
申请号：EP09725177.1
申请日：2009-03-26
发明人： ANGIBAUD, Patrick René , MEVELLEC, Laurence, Anne , ROUX, Bruno , STORCK, Pierre-Henri , MEYER, Christophe , VIALARD, Jorge Eduardo
IPC分类号： C07D221/12 , C07D401/06 , A61K31/473 , A61P35/00
CPC分类号： C07D401/06 , A61K31/4353 , C07D221/12
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公开(公告)号：EP2134691A1
公开(公告)日：2009-12-23
申请号：EP08717511.3
申请日：2008-03-07
发明人： VIALARD, Jorge Eduardo , ANGIBAUD, Patrick René , MEVELLEC, Laurence Anne , MEYER, Christophe , FREYNE, Eddy Jean Edgard , PILATTE, Isabelle Noëlle Constance , ROUX, Bruno , PASQUIER, Elisabeth Thérèse Jeanne , BOURDREZ, Xavier Marc , ADELINET, Christophe Denis , MARCONNET-DECRANE, Laurence Françoise Bernadette , MACRITCHIE, Jacqueline Anne , DUFFY, James Edward Stewart , OWENS, Andrew Pate , STORCK, Pierre-Henri , PONCELET, Virginie Sophie
IPC分类号： C07D215/22 , A61K31/4704
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
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公开(公告)号：EP3233862A1
公开(公告)日：2017-10-25
申请号：EP15810784.7
申请日：2015-12-18
发明人： MEVELLEC, Laurence, Anne , MEERPOEL, Lieven , COUPA, Sophie , PONCELET, Virginie, Sophie , PILATTE, Isabelle, Noëlle, Constance , PASQUIER, Elisabeth, Thérèse, Jeanne , BERTHELOT, Didier, Jean-Claude , QUEROLLE, Olivier, Alexis, Georges , MEYER, Christophe , ANGIBAUD, Patrick, René , DEMESTRE, Christophe, Gabriel, Marcel , MERCEY, Guillaume, Jean, Maurice
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及式（I）的取代的咪唑并哒嗪衍生物，其中各变量具有权利要求书中定义的含义。 根据本发明的化合物可用作p13Kβ抑制剂。 本发明进一步涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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公开(公告)号：EP2134691B1
公开(公告)日：2012-01-25
申请号：EP08717511.3
申请日：2008-03-07
发明人： VIALARD, Jorge Eduardo , ANGIBAUD, Patrick René , MEVELLEC, Laurence Anne , MEYER, Christophe , FREYNE, Eddy Jean Edgard , PILATTE, Isabelle Noëlle Constance , ROUX, Bruno , PASQUIER, Elisabeth Thérèse Jeanne , BOURDREZ, Xavier Marc , ADELINET, Christophe Denis , MARCONNET-DECRANE, Laurence Françoise Bernadette , MACRITCHIE, Jacqueline Anne , DUFFY, James Edward Stewart , OWENS, Andrew Pate , STORCK, Pierre-Henri , PONCELET, Virginie Sophie
IPC分类号： C07D215/22 , A61K31/4704
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
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公开(公告)号：EP2260026A1
公开(公告)日：2010-12-15
申请号：EP09724207.7
申请日：2009-03-26
发明人： FREYNE, Eddy Jean Edgard , MEVELLEC, Laurence Anne , VIALARD, Jorge Eduardo , MEYER, Christophe , PASQUIER, Elisabeth Thérèse Jeanne , BOURDREZ, Xavier Marc , ANGIBAUD, Patrick René
IPC分类号： C07D239/80 , C07D401/06 , C07D417/06 , A61K31/517 , A61P35/00
CPC分类号： C07D239/80 , C07D401/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , n, m and X have defined meanings.摘要翻译： 本发明提供式（I）化合物，它们作为微管蛋白聚合抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R 1，R 2，R 3，R 4，R 5，R 6， n，m和X具有定义的含义。
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公开(公告)号：EP2001868A1
公开(公告)日：2008-12-17
申请号：EP07727057.7
申请日：2007-03-19
发明人： LACRAMPE, Jean, Fernand, Armand , MEYER, Christophe , SCHOENTJES, Bruno , LARDEAU, Delphine, Yvonne, Raymonde , PONCELET, Alain, Philippe , VAN HIJFTE, Luc
IPC分类号： C07D401/12 , C07D405/12 , C07D471/04 , A61K31/4409 , A61P35/00
CPC分类号： C07D405/12 , C07D401/12 , C07D471/04
摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, A and Z have defined meanings.
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7.发明授权QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS 有权喹唑啉酮衍生物，ALS TUBULINPOLYMERISATIONSHEMMER
公开(公告)号：EP2260026B1
公开(公告)日：2011-06-22
申请号：EP09724207.7
申请日：2009-03-26
发明人： FREYNE, Eddy Jean Edgard , MEVELLEC, Laurence Anne , VIALARD, Jorge Eduardo , MEYER, Christophe , PASQUIER, Elisabeth Thérèse Jeanne , BOURDREZ, Xavier Marc , ANGIBAUD, Patrick René
IPC分类号： C07D239/80 , C07D401/06 , C07D417/06 , A61K31/517 , A61P35/00
CPC分类号： C07D239/80 , C07D401/06 , C07D417/06
摘要： The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , n, m and X have defined meanings.-
8.发明授权CYCLIC-ALKYLAMINEDERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 有权BETWEEN MDM2与p53相互作用的CYCLOALKYLAMINDERIVATE作为抑制剂
公开(公告)号：EP1999126B1
公开(公告)日：2010-06-09
申请号：EP07727060.1
申请日：2007-03-19
发明人： LACRAMPE, Jean, Fernand, Armand , MEYER, Christophe , SCHOENTJES, Bruno , PONCELET, Alain, Philippe , WERMUTH, Camille, Georges , GIETHLEN, Bruno , CONTRERAS, Jean-Marie , JOUBERT, Muriel , VAN HIJFTE, Luc
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/4709 , A61P35/00
CPC分类号： C07D401/14
摘要： The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, t, R1 , R2 , R3, R4, R5, R6, R7, Q, Y and Z have defined meanings.
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9.发明公开IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER 有权咪唑啉-5-酮衍生物作为脂肪酸合酶（FASN）一种癌的治疗抑制剂
公开(公告)号：EP2892892A1
公开(公告)日：2015-07-15
申请号：EP13762696.6
申请日：2013-09-06
发明人： BIGNAN, Gilles C. , CONNOLLY, Peter J. , LU, Tianbao L. , PARKER, Michael H. , LUDOVICI, Donald , MEYER, Christophe , MEERPOEL, Lieven , SMANS, Karine , ROCABOY, Christian
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/06 , C07D403/06 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/10 , C07D491/107 , C07D498/04 , A61K31/4184 , A61K31/4188
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/10 , C07D491/107 , C07D498/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L
1 , a, b, m, n, R
1 , R
2 , R
3 , R
4 , and R
5 are defined herein.摘要翻译： 本发明公开了化合物，组合物和方法用于治疗各种疾病，综合征，病症和障碍，包括那些通过抑制脂肪酸合酶（FASN）的酶介导的：如，癌症，肥胖症或相关盘订单，肝相关疾病。 搜索化合物由式（I）表示如下：其中L 1，A，B，M，N，R1，R2，R3，R4，和R5中的定义。
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10.发明公开TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS 有权四氢噻蒽和四氢环戊烯醇作为PARP和微管聚合抑制剂
公开(公告)号：EP2271626A1
公开(公告)日：2011-01-12
申请号：EP09725177.1
申请日：2009-03-26
发明人： ANGIBAUD, Patrick René , MEVELLEC, Laurence, Anne , ROUX, Bruno , STORCK, Pierre-Henri , MEYER, Christophe , VIALARD, Jorge Eduardo
IPC分类号： C07D221/12 , C07D401/06 , A61K31/473 , A61P35/00
CPC分类号： C07D401/06 , A61K31/4353 , C07D221/12
摘要： The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 and Y have defined meanings.摘要翻译： 本发明提供式（I）化合物，它们作为微管蛋白聚合抑制剂的用途及其作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7和Y具有限定的含义。
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