公开(公告)号：EP1535629A1

公开(公告)日：2005-06-01

申请号：EP03764186.7

申请日：2003-07-14

申请人： Japan Science and Technology Agency ,  OSAKA BIOSCIENCE INSTITUTE ,  TAIHO PHARMACEUTICAL COMPANY LIMITED ,  SHIONOGI & CO., LTD.

发明人： URADE, Y., 503, Granshitio-Shimogamo-Shikisaikan ,  EGUCHI, Naomi ,  ARITAKE, Kosuke ,  SATO, Yo ,  KADOYAMA, Keiichi ,  TANIIKE, Masako

IPC分类号： A61K45/00 ,  A61K31/454 ,  A61K31/53 ,  A61K31/381 ,  A61P25/00 ,  A61P43/00

CPC分类号： A61K45/06 ,  A61K31/381 ,  A61K31/454 ,  A61K31/53 ,  G01N33/5088 ,  G01N33/6896 ,  G01N33/88

摘要： There are provided a compound for treatment or prevention of brain injury caused by diseases such as cerebrovascular disorder, brain degenerative disease and demyelinating disease and a method for screening the same.
Brain injury in which prostaglandin D 2 is participated is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by inhibition of activation of prostaglandin D receptor expressed in astroglia cell around the injured area. There is also provided a method of testing those pharmaceutical substances using a transgenic mouse in which human hematopoietic prostaglandin D synthase is expressed in large amounts.

摘要翻译： 提供了治疗或预防由脑血管病，脑退行性疾病和脱髓鞘疾病等疾病引起的脑损伤的化合物及其筛选方法。 通过抑制由脑血管障碍，脑退行性疾病或脱髓鞘疾病等疾病引起的小脑胶质细胞或脑损伤区域的巨噬细胞诱导的造血前列腺素D合成酶来治疗或预防前列腺素D2参与的脑损伤 在受伤区域周围的星形胶质细胞中表达的前列腺素D受体的活化。 还提供了使用其中大量表达人造血前列腺素D合成酶的转基因小鼠来测试这些药物物质的方法。

公开(公告)号：EP1574569A1

公开(公告)日：2005-09-14

申请号：EP03780880.5

申请日：2003-12-18

申请人： RIKEN ,  OSAKA BIOSCIENCE INSTITUTE

发明人： MIYANO, Masashi c/o RIKEN, Harima Institute ,  YAMAMOTO, Masaki c/o RIKEN, Harima Institute ,  KUMASAKA, Takashi c/o RIKEN, Harima Institute ,  AGO, Hideo c/o RIKEN, Harima Institute ,  URADE, Y. 503, Granshitio-Shimogamo-Shikisaikan, ,  IRIKURA, Daisuke ,  ARITAKE, Kosuke

IPC分类号： C12N9/90 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/533 ,  C07D401/06 ,  G06F17/30 ,  G06F17/50 ,  G01N33/50

CPC分类号： C12N9/0004 ,  C07K2299/00 ,  C12Q1/533

摘要： Crystals of lipocalin-type prostaglandin D synthase are produced and analyzed by X-ray difratometry to give the three dimensional structure of enzyme based on which an inhibitor of the enzyme can be designed and selected.

摘要翻译： 通过X射线分光光度法测定脂笼蛋白型前列腺素D合成酶的晶体，得到酶的三维结构，根据该结构可以设计和选择酶的抑制剂。

公开(公告)号：EP2407784A1

公开(公告)日：2012-01-18

申请号：EP10750778.2

申请日：2010-03-08

申请人： Osaka Bioscience Institute ,  National Center of Neurology and Psychiatry ,  Taiho Pharmaceutical Co., Ltd.

发明人： URADE, Yoshihiro ,  ARITAKE, Kosuke ,  MARUYAMA, Toshihiko ,  KAMAUCHI, Shinya ,  TAKEDA, Shin'ichi ,  NAKAMURA, Akinori

IPC分类号： G01N33/53 ,  G01N27/62 ,  G01N30/72 ,  G01N30/88 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/6893 ,  G01N30/7233 ,  G01N2030/8813 ,  G01N2800/28 ,  G01N2800/2878

摘要： Muscle degenerative diseases can be detected in the early stage and the therapeutic efficacy of a therapeutic agent and/or a therapy method for the diseases can be determined by measuring 11,15-dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (referred to as "Tetranor-PGDM", hereinbelow) in a sample isolated from a subject.

公开(公告)号：EP1882937A1

公开(公告)日：2008-01-30

申请号：EP06746503.9

申请日：2006-05-17

申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED

发明人： URADE, Yoshihiro, 503, Granshitio-Shimogamo-Shikisaikan ,  EGUCHI, Naomi ,  ARITAKE, Kosuke ,  HYO, Sawako, 128, Takatsuji-Omiya-cho ,  TAKENAKA, Hiroshi ,  KAWATA, Ryo

IPC分类号： G01N33/53 ,  G01N33/48 ,  G01N33/564

CPC分类号： G01N33/88 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0368 ,  C12N9/90 ,  C12N15/8509 ,  C12Q1/26 ,  G01N2800/24

摘要： A method for diagnosis of the severity of a condition in an eosinophilic inflammatory disease such as nasal polyp or for prediction of the recurrence of the disease, the method comprising detecting H-PGDS induced by eosinophilic leukocytes accumulated in a lesion or determining pGD 2 in a nasal alveolar lavage fluid or Bronchoalveolar lavage fluid

摘要翻译： 用于诊断嗜酸性炎性疾病如鼻息肉中的病症的严重程度或用于预测疾病复发的方法，所述方法包括检测累积在病变中的嗜酸粒细胞白细胞诱导的H-PGDS或在病变中确定pGD 2 鼻腔灌洗液或支气管肺泡灌洗液