公开(公告)号：EP2489350B1

公开(公告)日：2013-12-04

申请号：EP12155608.8

申请日：2007-03-16

申请人： Johns Hopkins University School of Medicine ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Brookfield, Frederick, Arthur ,  Cohen, Andrew, D. ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07D207/36 ,  C07D213/71 ,  C07D213/74 ,  C07D231/18 ,  C07D233/84 ,  C07D239/38 ,  C07D241/18 ,  C07D249/12 ,  C07D261/10 ,  C07D277/36 ,  C07D285/12 ,  C07D295/096 ,  C07D307/64 ,  C07D307/82 ,  C07D333/34 ,  C07D333/62 ,  C07D263/58 ,  C07D285/125

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N -hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N -hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：EP2489350A1

公开(公告)日：2012-08-22

申请号：EP12155608.8

申请日：2007-03-16

申请人： Johns Hopkins University School of Medicine ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Brookfield, Frederick, Arthur ,  Cohen, Andrew, D. ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07D207/36 ,  C07D213/71 ,  C07D213/74 ,  C07D231/18 ,  C07D233/84 ,  C07D239/38 ,  C07D241/18 ,  C07D249/12 ,  C07D261/10 ,  C07D277/36 ,  C07D285/12 ,  C07D307/64 ,  C07D333/34

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

公开(公告)号：EP2586434A1

公开(公告)日：2013-05-01

申请号：EP12195118.0

申请日：2007-03-16

申请人： Johns Hopkins University School of Medicine ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Brookfield, Frederick, Arthur ,  Cohen, Andrew, D. ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07D213/74 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D307/82 ,  C07D333/62

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N- hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N- hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以受控的速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：EP2586433A1

公开(公告)日：2013-05-01

申请号：EP12195114.9

申请日：2007-03-16

申请人： Johns Hopkins University School of Medicine ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Brookfield, Frederick, Arthur ,  Cohen, Andrew, D ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07D213/74 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D307/82 ,  C07D333/62

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemla/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以可控速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：EP2596785A1

公开(公告)日：2013-05-29

申请号：EP12195128.9

申请日：2007-03-16

申请人： Johns Hopkins University School of Medicine ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Brookfield, Frederick, Arthur ,  Cohen, Andrew, D. ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D207/36 ,  C07D213/71 ,  C07D213/74

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N -hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N -hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以受控的速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：EP2586435A1

公开(公告)日：2013-05-01

申请号：EP12195124.8

申请日：2007-03-16

申请人： Johns Hopkins University School of Medicine ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Cohen, Andrew, D. ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob ,  Brookfield, Frederick, Arthur

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07C311/48 ,  C07C317/14 ,  C07C323/67

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N -hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N -hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及N-羟基磺酰胺衍生物，其在生理条件下提供硝酰基（HNO）并且可用于治疗和/或预防对硝酰基疗法有响应的疾病或病症的发作和/或发展，所述疾病或病症包括心力衰竭和局部缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以受控速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：EP2586435B1

公开(公告)日：2016-09-14

申请号：EP12195124.8

申请日：2007-03-16

申请人： The Johns Hopkins University ,  Cardioxyl Pharmaceuticals, Inc.

发明人： Toscano, John, P. ,  Cohen, Andrew, D. ,  Courtney, Stephen, Martin ,  Frost, Lisa, Marie ,  Kalish, Vincent, Jacob ,  Brookfield, Frederick, Arthur

IPC分类号： A61K31/18 ,  A61P9/04 ,  C07C311/48 ,  C07C317/14 ,  C07C323/67

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62