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    ESTERS FOR TREATMENT OF OCULAR INFLAMMATORY CONDITIONS
    2.
    发明公开
    ESTERS FOR TREATMENT OF OCULAR INFLAMMATORY CONDITIONS 有权
    隐形眼镜包含酯或抗炎脂质介体用于眼睛炎症的治疗中的酰胺

    公开(公告)号：EP2726061A1

    公开(公告)日：2014-05-07

    申请号：EP12742973.6

    申请日：2012-06-19

    申请人： Johnson & Johnson Vision Care Inc.

    发明人： GALLOIS-BERNOS, Annabelle ,  MOLOCK, JR., Frank, F. ,  DAVIS, Carrie, L. ,  LORENZ, Kathy, Osborn ,  YOUNG, James, K. ,  CANAVAN, Kristy, L. ,  LU, Fang

    IPC分类号： A61K9/00 ,  A61K31/16 ,  A61K31/201 ,  A61K31/202 ,  A61K31/203 ,  A61K31/557 ,  A61P27/02 ,  A61P27/04

    CPC分类号： A61K31/232 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/16 ,  A61K31/201 ,  A61K31/202 ,  A61K31/203 ,  A61K31/215 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/661 ,  A61K31/683

    摘要： The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti¬ inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g., omega-three and omega-six fatty acids), resolvins or a metabolically stable analog, protectins or a metabolically stable analog, lipoxins or a metabolically stable analog, prostaglandins or a metabolically stable analog, retinoic acids, endocannabinoids, metabolites thereof, and mixtures thereof. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.

    摘要翻译： 本发明涉及眼用组合物和用于干眼症等眼炎症性疾病的治疗方法。 特别地，本发明涉及包含酯化抗炎脂质介体的组合物，所有这些是在抗炎脂质介质的酯所做的是抗炎脂质介体的反应产物与一元醇或酰胺worin的 大多数抗炎脂质介质的是存在于酯的形式。在这种方式中，组合物基本上不含抗炎脂质介质的酸形式的。 该组合物可以通过制备，溶液，凝胶，软膏，和/或带和/或接触透镜来局部递送到眼表面。

    POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE
    3.
    发明授权
    POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE 有权

    公开(公告)号：EP3494168B1

    公开(公告)日：2020-04-29

    申请号：EP17757937.2

    申请日：2017-08-01

    申请人： Johnson & Johnson Vision Care, Inc.

    发明人： AITKEN, Brian ,  SCALES, Charles ,  JOSLIN, Scott ,  ZHANG, Yong ,  SINHA, Dola ,  MAHADEVAN, Shivkumar ,  MARTIN, Patricia ,  LU, Fang ,  DUIS, Donnie ,  ARNOLD, Stephen C.

    IPC分类号： C08J7/16 ,  C08F283/12

    摘要： Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

    POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE
    4.
    发明公开
    POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE 有权

    公开(公告)号：EP3494168A1

    公开(公告)日：2019-06-12

    申请号：EP17757937.2

    申请日：2017-08-01

    申请人： Johnson & Johnson Vision Care, Inc.

    发明人： AITKEN, Brian ,  SCALES, Charles ,  JOSLIN, Scott ,  ZHANG, Yong ,  SINHA, Dola ,  MAHADEVAN, Shivkumar ,  MARTIN, Patricia ,  LU, Fang ,  DUIS, Donnie ,  ARNOLD, Stephen C.

    IPC分类号： C08J7/16 ,  C08F283/12

    摘要： Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.