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1.发明公开USE OF HETEROLOGOUS EXPRESSED POLYKETIDE SYNTHASE AND SMALL MOLECULE FOLDASES TO MAKE AROMATIC AND CYCLIC COMPOUNDS 审中-公开异源表达多肽合成酶和小分子折叠物用于制备芳香族和环状化合物
公开(公告)号：EP3307900A1
公开(公告)日：2018-04-18
申请号：EP16732964.8
申请日：2016-06-10
发明人： FRANDSEN, Rasmus John Normand , MORTENSEN, Uffe Hasbro , COUMOU, Hilde Cornelijne , KANNANGARA, Rubini Maya , MADSEN, Bjørn , NAFISI, Majse , ANDERSEN-RANBERG, Johan , KONGSTAD, Kenneth Thermann , OKKELS, Finn Thyge , KHORSAND-JAMAL, Paiman , STÆRK, Dan , MØLLER, Birger Lindberg
CPC分类号： C12N15/8257 , C12N9/93 , C12P5/005 , C12P7/26 , C12P7/40 , C12P17/06 , C12P19/60 , C12Y203/01 , C12Y604/00 , C40B50/06
摘要： A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.
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公开(公告)号：EP4204576A1
公开(公告)日：2023-07-05
申请号：EP21769944.6
申请日：2021-08-26
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3.发明公开USE OF OCTAKETIDE SYNTHASES TO PRODUCE KERMESIC ACID AND FLAVOKERMESIC ACID 审中-公开使用奥他卡因合成法生产杀菌酸和黄酮羧酸
公开(公告)号：EP3307899A1
公开(公告)日：2018-04-18
申请号：EP16732500.0
申请日：2016-06-10
发明人： MØLLER, Birger Lindberg , MADSEN, Bjørn , STÆRK, Dan , OKKELS, Finn Thyge , ANDERSEN-RANBERG, Johan , KONGSTAD, Kenneth Thermann , BINDERUP, Kim , BENNEDSEN, Mads , NAFISI, Majse , KHORSAND-JAMAL, Paiman , KANNANGARA, Rubini Maya , MORTENSEN, Uffe Hasbro , THRANE, Ulf , FRANDSEN, Rasmus John Normand
摘要： A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).
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